Question 1

The gene on chromosome 21 encoding which protein is thought to contribute to the increased risk of Alzheimer's disease in individuals with Down syndrome?

Accepted Answer

A)  Presenilin 1 
B)  Presenilin 2 
C)  Amyloid precursor protein 
D)  Alpha-synuclein 
E)  Parkin 
A)  Presenilin 1 
B)  Presenilin 2 
C)  Amyloid precursor protein 
D)  Alpha-synuclein 
E)  Parkin C

Question 2

If a migrant group moves from an area with a low incidence of a particular disease to an area with a high incidence of that disease and the disease incidence in that group subsequently increases to match the incidence in the second location,what does this suggest about the disease etiology?

Accepted Answer

A)  It is mostly genetic 
B)  It is mostly environmental 
C)  It is caused by both genetic and environmental factors 
D)  It is caused by food 
E)  Further research needs to be done 
A)  It is mostly genetic 
B)  It is mostly environmental 
C)  It is caused by both genetic and environmental factors 
D)  It is caused by food 
E)  Further research needs to be done B

Question 3

Which of the following classes of proteins has been associated with several genetic forms of epilepsy?

Accepted Answer

A)  Transcription factors 
B)  Chaperones 
C)  Mitochondrial proteins 
D)  Ion channels 
E)  Growth factor receptors 
A)  Transcription factors 
B)  Chaperones 
C)  Mitochondrial proteins 
D)  Ion channels 
E)  Growth factor receptors D

Question 4

What is the major locus contributing to type 1 diabetes?

Accepted Answer

A)  HNF1A 
B)  CARD15 
C)  HLA 
D)  TCF7L2 
E)  APOE 
A)  HNF1A 
B)  CARD15 
C)  HLA 
D)  TCF7L2 
E)  APOE

Question 5

One could best tease apart the genetic and environmental causes of a trait through comparisons of which of the following groups?

Accepted Answer

A)  First-degree relatives versus second-degree relatives 
B)  Sisters versus brothers 
C)  Monozygotic versus dizygotic twins 
D)  Parents versus children 
E)  Twins versus siblings 
A)  First-degree relatives versus second-degree relatives 
B)  Sisters versus brothers 
C)  Monozygotic versus dizygotic twins 
D)  Parents versus children 
E)  Twins versus siblings

Question 6

Why is population genetic screening for hemochromatosis not recommended?

Accepted Answer

A)  The low frequency of carriers 
B)  No treatment is available 
C)  High allelic heterogeneity 
D)  Because it manifests only late it life 
E)  Low penetrance of the mutations 
A)  The low frequency of carriers 
B)  No treatment is available 
C)  High allelic heterogeneity 
D)  Because it manifests only late it life 
E)  Low penetrance of the mutations

Question 7

The Factor V Leiden mutation is associated with:

Accepted Answer

A) Reduced cleavage of Factor V by Protein C 
B)  A low carrier frequency 
C)  Decreased clotting 
D)  Resolution of phenotype during puberty 
E)  Delayed presentation due to fetal hemoglobin expression 
A) Reduced cleavage of Factor V by Protein C 
B)  A low carrier frequency 
C)  Decreased clotting 
D)  Resolution of phenotype during puberty 
E)  Delayed presentation due to fetal hemoglobin expression

The gene on chromosome 21 encoding which protein is thought to contribute to the increased risk of Alzheimer's disease in individuals with Down syndrome?

If a migrant group moves from an area with a low incidence of a particular disease to an area with a high incidence of that disease and the disease incidence in that group subsequently increases to match the incidence in the second location,what does this suggest about the disease etiology?

Which of the following classes of proteins has been associated with several genetic forms of epilepsy?

What is the major locus contributing to type 1 diabetes?

One could best tease apart the genetic and environmental causes of a trait through comparisons of which of the following groups?

Why is population genetic screening for hemochromatosis not recommended?

The Factor V Leiden mutation is associated with:

The History and Impact of Genetics in Medicine

The Cellular and Molecular Basis of Inheritance

Chromosomes and Cell Division

Dna Technology and Applications

Mapping and Identifying Genes for Monogenic Disorders

Developmental Genetics

Patterns of Inheritance

Population and Mathematical Genetics

Polygenic and Multifactorial Inheritance

Hemoglobin and the Hemoglobinopathies

Biochemical Genetics

Pharmacogenetics

Immunogenetics

Cancer Genetics

Congenital Abnormalities and Dysmorphic Syndromes

Genetic Counseling

Chromosome Disorders

Single-Gene Disorders

Screening for Genetic Disease

Prenatal Testing and Reproductive Genetics

Risk Calculation

Treatment of Genetic Disease

Ethical and Legal Issues in Medical Genetics

Filters

Exam 15: Genetic Factors in Common Diseases

The gene on chromosome 21 encoding which protein is thought to contribute to the increased risk of Alzheimer's disease in individuals with Down syndrome?

If a migrant group moves from an area with a low incidence of a particular disease to an area with a high incidence of that disease and the disease incidence in that group subsequently increases to match the incidence in the second location,what does this suggest about the disease etiology?

Which of the following classes of proteins has been associated with several genetic forms of epilepsy?

What is the major locus contributing to type 1 diabetes?

One could best tease apart the genetic and environmental causes of a trait through comparisons of which of the following groups?

Why is population genetic screening for hemochromatosis not recommended?

The Factor V Leiden mutation is associated with:

The History and Impact of Genetics in Medicine

The Cellular and Molecular Basis of Inheritance

Chromosomes and Cell Division

Dna Technology and Applications

Mapping and Identifying Genes for Monogenic Disorders

Developmental Genetics

Patterns of Inheritance

Population and Mathematical Genetics

Polygenic and Multifactorial Inheritance

Hemoglobin and the Hemoglobinopathies

Biochemical Genetics

Pharmacogenetics

Immunogenetics

Cancer Genetics

Congenital Abnormalities and Dysmorphic Syndromes

Genetic Counseling

Chromosome Disorders

Single-Gene Disorders

Screening for Genetic Disease

Prenatal Testing and Reproductive Genetics

Risk Calculation

Treatment of Genetic Disease

Ethical and Legal Issues in Medical Genetics

Filters