Question 1

How is the translocation between chromosomes 8 and 14 thought to cause Burkitt lymphoma?

Accepted Answer

A)  It puts a proto-oncogene downstream of a strong promoter 
B)  It fuses a proto-oncogene with another protein and alters its activity 
C)  It deletes its opposing tumor suppressor 
D)  It deletes a regulatory region for the gene 
E)  It removes its 3' UTR 
A)  It puts a proto-oncogene downstream of a strong promoter 
B)  It fuses a proto-oncogene with another protein and alters its activity 
C)  It deletes its opposing tumor suppressor 
D)  It deletes a regulatory region for the gene 
E)  It removes its 3' UTR A

Question 2

How does the Philadelphia chromosome activate an oncogene?

Accepted Answer

A)  It puts a proto-oncogene downstream of a strong promoter 
B)  It fuses a proto-oncogene with another protein and alters its activity 
C)  It deletes its opposing tumor suppressor 
D)  It deletes a regulatory region for the gene 
E)  It removes its 3' UTR 
A)  It puts a proto-oncogene downstream of a strong promoter 
B)  It fuses a proto-oncogene with another protein and alters its activity 
C)  It deletes its opposing tumor suppressor 
D)  It deletes a regulatory region for the gene 
E)  It removes its 3' UTR B

Question 3

In addition to mutations in the coding region and regulatory elements,oncogenes often arise by which mechanism?

Accepted Answer

A)  Gene amplification 
B)  Loss of heterozygosity 
C)  Splice mutations 
D)  Interstitial deletions 
E)  Nondisjunction 
A)  Gene amplification 
B)  Loss of heterozygosity 
C)  Splice mutations 
D)  Interstitial deletions 
E)  Nondisjunction A

Question 4

Mismatch repair defects causing hereditary nonpolyposis colon cancer are associated with which molecular phenomenon,which can be helpful for diagnosis?

Accepted Answer

A)  DNA hypomethylation 
B)  DNA hypermethylation 
C)  DNA hypercondensation 
D)  Microsatellite instability 
E)  DNA breakage 
A)  DNA hypomethylation 
B)  DNA hypermethylation 
C)  DNA hypercondensation 
D)  Microsatellite instability 
E)  DNA breakage

Question 5

Following a first mutation in a tumor suppressor gene,which of the following is commonly associated with the "second hit" in tumor generation?

Accepted Answer

A)  Loss of heterozygosity 
B)  Fusion of two genes 
C)  Insertional mutagenesis 
D)  Gene duplication 
E)  Any of the above 
A)  Loss of heterozygosity 
B)  Fusion of two genes 
C)  Insertional mutagenesis 
D)  Gene duplication 
E)  Any of the above

Question 6

Loss of telomerase expression prevents cells from doing which of the following?

Accepted Answer

A)  Repairing mismatch mutations 
B)  Regulating their cell cycle appropriately 
C)  Dividing indefinitely 
D)  Synthesizing the leading DNA strand during replication 
E)  Becoming senescent 
A)  Repairing mismatch mutations 
B)  Regulating their cell cycle appropriately 
C)  Dividing indefinitely 
D)  Synthesizing the leading DNA strand during replication 
E)  Becoming senescent

Question 7

Which of the following epigenetic modifications is associated with cancer?

Accepted Answer

A)  DNA hypermethylation 
B)  DNA hypomethylation 
C)  Histone hypoacetylation 
D)  All of the above 
E)  None of the above 
A)  DNA hypermethylation 
B)  DNA hypomethylation 
C)  Histone hypoacetylation 
D)  All of the above 
E)  None of the above

Question 8

Which of the following classes of proteins are likely to be encoded by proto-oncogenes?

Accepted Answer

A)  Mismatch repair proteins 
B)  Apoptosis inducing proteins 
C)  Negative regulators of the cell cycle 
D)  Growth factor receptors 
E)  Proteins involved in homologous recombination 
A)  Mismatch repair proteins 
B)  Apoptosis inducing proteins 
C)  Negative regulators of the cell cycle 
D)  Growth factor receptors 
E)  Proteins involved in homologous recombination

How is the translocation between chromosomes 8 and 14 thought to cause Burkitt lymphoma?

How does the Philadelphia chromosome activate an oncogene?

In addition to mutations in the coding region and regulatory elements,oncogenes often arise by which mechanism?

Mismatch repair defects causing hereditary nonpolyposis colon cancer are associated with which molecular phenomenon,which can be helpful for diagnosis?

Following a first mutation in a tumor suppressor gene,which of the following is commonly associated with the "second hit" in tumor generation?

Loss of telomerase expression prevents cells from doing which of the following?

Which of the following epigenetic modifications is associated with cancer?

Which of the following classes of proteins are likely to be encoded by proto-oncogenes?

The History and Impact of Genetics in Medicine

The Cellular and Molecular Basis of Inheritance

Chromosomes and Cell Division

Dna Technology and Applications

Mapping and Identifying Genes for Monogenic Disorders

Developmental Genetics

Patterns of Inheritance

Population and Mathematical Genetics

Polygenic and Multifactorial Inheritance

Hemoglobin and the Hemoglobinopathies

Biochemical Genetics

Pharmacogenetics

Immunogenetics

Genetic Factors in Common Diseases

Congenital Abnormalities and Dysmorphic Syndromes

Genetic Counseling

Chromosome Disorders

Single-Gene Disorders

Screening for Genetic Disease

Prenatal Testing and Reproductive Genetics

Risk Calculation

Treatment of Genetic Disease

Ethical and Legal Issues in Medical Genetics

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Exam 14: Cancer Genetics

How is the translocation between chromosomes 8 and 14 thought to cause Burkitt lymphoma?

How does the Philadelphia chromosome activate an oncogene?

In addition to mutations in the coding region and regulatory elements,oncogenes often arise by which mechanism?

Mismatch repair defects causing hereditary nonpolyposis colon cancer are associated with which molecular phenomenon,which can be helpful for diagnosis?

Following a first mutation in a tumor suppressor gene,which of the following is commonly associated with the "second hit" in tumor generation?

Loss of telomerase expression prevents cells from doing which of the following?

Which of the following epigenetic modifications is associated with cancer?

Which of the following classes of proteins are likely to be encoded by proto-oncogenes?

The History and Impact of Genetics in Medicine

The Cellular and Molecular Basis of Inheritance

Chromosomes and Cell Division

Dna Technology and Applications

Mapping and Identifying Genes for Monogenic Disorders

Developmental Genetics

Patterns of Inheritance

Population and Mathematical Genetics

Polygenic and Multifactorial Inheritance

Hemoglobin and the Hemoglobinopathies

Biochemical Genetics

Pharmacogenetics

Immunogenetics

Genetic Factors in Common Diseases

Congenital Abnormalities and Dysmorphic Syndromes

Genetic Counseling

Chromosome Disorders

Single-Gene Disorders

Screening for Genetic Disease

Prenatal Testing and Reproductive Genetics

Risk Calculation

Treatment of Genetic Disease

Ethical and Legal Issues in Medical Genetics

Filters