Question 1

Which of the following should be avoided in an individual with a mutation in the ryanodine receptor RYR1?

Accepted Answer

A)  Anesthesia using halothane 
B)  Periods of fasting 
C)  Isoniazid treatment 
D)  Chemotherapy with 5-fluorouracil 
E)  Alcohol consumption 
A)  Anesthesia using halothane 
B)  Periods of fasting 
C)  Isoniazid treatment 
D)  Chemotherapy with 5-fluorouracil 
E)  Alcohol consumption A

Question 2

When treated with isoniazid,people who are homozygous for an allele associated with low N-acetyltransferase activity are at risk for which of the following?

Accepted Answer

A)  Inability to maintain sufficient levels of isoniazid for treatment 
B)  Polyneuritis 
C)  Inability to absorb sufficient isoniazid 
D)  Hemolysis 
E)  Sudden death 
A)  Inability to maintain sufficient levels of isoniazid for treatment 
B)  Polyneuritis 
C)  Inability to absorb sufficient isoniazid 
D)  Hemolysis 
E)  Sudden death B

Question 3

For the most effective use of Herceptin in breast cancer treatment,molecular testing for which of the following proteins should be performed before the drug is prescribed?

Accepted Answer

A)  BRCA1 
B)  BRCA2 
C)  HER2 
D)  EGFR 
E)  MTHFR 
A)  BRCA1 
B)  BRCA2 
C)  HER2 
D)  EGFR 
E)  MTHFR C

Question 4

What would you predict about the genes involved in a drug's metabolism if you see a discontinuous dose-response curve in a population?

Accepted Answer

A)  One gene is mainly responsible for the metabolism 
B)  The number of genes involved in the metabolism is equal to the number of peaks in the response curve 
C)  There are multiple genes involved in the metabolism, but this would not tell you how many 
D)  There is a threshold for induction of the gene involved in the metabolism 
E)  A dose-response curve provides no information on the genetics of drug metabolism 
A)  One gene is mainly responsible for the metabolism 
B)  The number of genes involved in the metabolism is equal to the number of peaks in the response curve 
C)  There are multiple genes involved in the metabolism, but this would not tell you how many 
D)  There is a threshold for induction of the gene involved in the metabolism 
E)  A dose-response curve provides no information on the genetics of drug metabolism

Which of the following should be avoided in an individual with a mutation in the ryanodine receptor RYR1?

When treated with isoniazid,people who are homozygous for an allele associated with low N-acetyltransferase activity are at risk for which of the following?

For the most effective use of Herceptin in breast cancer treatment,molecular testing for which of the following proteins should be performed before the drug is prescribed?

What would you predict about the genes involved in a drug's metabolism if you see a discontinuous dose-response curve in a population?

The History and Impact of Genetics in Medicine

The Cellular and Molecular Basis of Inheritance

Chromosomes and Cell Division

Dna Technology and Applications

Mapping and Identifying Genes for Monogenic Disorders

Developmental Genetics

Patterns of Inheritance

Population and Mathematical Genetics

Polygenic and Multifactorial Inheritance

Hemoglobin and the Hemoglobinopathies

Biochemical Genetics

Immunogenetics

Cancer Genetics

Genetic Factors in Common Diseases

Congenital Abnormalities and Dysmorphic Syndromes

Genetic Counseling

Chromosome Disorders

Single-Gene Disorders

Screening for Genetic Disease

Prenatal Testing and Reproductive Genetics

Risk Calculation

Treatment of Genetic Disease

Ethical and Legal Issues in Medical Genetics

Filters

Exam 12: Pharmacogenetics

Which of the following should be avoided in an individual with a mutation in the ryanodine receptor RYR1?

When treated with isoniazid,people who are homozygous for an allele associated with low N-acetyltransferase activity are at risk for which of the following?

For the most effective use of Herceptin in breast cancer treatment,molecular testing for which of the following proteins should be performed before the drug is prescribed?

What would you predict about the genes involved in a drug's metabolism if you see a discontinuous dose-response curve in a population?

The History and Impact of Genetics in Medicine

The Cellular and Molecular Basis of Inheritance

Chromosomes and Cell Division

Dna Technology and Applications

Mapping and Identifying Genes for Monogenic Disorders

Developmental Genetics

Patterns of Inheritance

Population and Mathematical Genetics

Polygenic and Multifactorial Inheritance

Hemoglobin and the Hemoglobinopathies

Biochemical Genetics

Immunogenetics

Cancer Genetics

Genetic Factors in Common Diseases

Congenital Abnormalities and Dysmorphic Syndromes

Genetic Counseling

Chromosome Disorders

Single-Gene Disorders

Screening for Genetic Disease

Prenatal Testing and Reproductive Genetics

Risk Calculation

Treatment of Genetic Disease

Ethical and Legal Issues in Medical Genetics

Filters