Question 1

The complete absence of a globin production gives rise to which phenotype?

Accepted Answer

A)  Sickle cell disease 
B)  Hb H disease 
C)  b-thalassemia 
D)  Hydrops fetalis 
E)  Normal adult hemoglobin production 
A)  Sickle cell disease 
B)  Hb H disease 
C)  b-thalassemia 
D)  Hydrops fetalis 
E)  Normal adult hemoglobin production D

Question 2

This region regulates the switching of the b-like globin chains during development.

Accepted Answer

A)  Locus control region 
B)  Master globin regulator 
C)  Imprinting control region 
D)  Globin switch 
E)  Immediate early region 
A)  Locus control region 
B)  Master globin regulator 
C)  Imprinting control region 
D)  Globin switch 
E)  Immediate early region A

Question 3

Which of the following statements is true regarding the a1 and a2 globin chains?

Accepted Answer

A)  They are identical at the nucleotide and amino acid sequence level 
B)  They differ at the nucleotide level but are identical at the amino acid level 
C)  a1 pairs only with b1, and a2 pairs only with b2 
D)  a1 is expressed in the fetus, and a2 is expressed after birth 
E)  a2 is a pseudogene of a1 
A)  They are identical at the nucleotide and amino acid sequence level 
B)  They differ at the nucleotide level but are identical at the amino acid level 
C)  a1 pairs only with b1, and a2 pairs only with b2 
D)  a1 is expressed in the fetus, and a2 is expressed after birth 
E)  a2 is a pseudogene of a1 B

Question 4

The HbA form of hemoglobin consists of which globin chains?

Accepted Answer

A)  1 a, 1 b 
B)  2 a, 2 b 
C)  2 a 
D)  2 a, 2 g 
E)  1 a, 1 g 
A)  1 a, 1 b 
B)  2 a, 2 b 
C)  2 a 
D)  2 a, 2 g 
E)  1 a, 1 g

Question 5

Which of the following statements is true of the sickle cell trait-associated form of hemoglobin,Hb S?

Accepted Answer

A)  It is characterized by a relative deficiency of a chains versus b chains 
B)  It has increased oxygen binding affinity relative to Hb A 
C)  It is less soluble than Hb A 
D)  It is dominant to Hb A 
E)  Therapeutic approaches have been highly successful in alleviating phenotypes associated with Hb S 
A)  It is characterized by a relative deficiency of a chains versus b chains 
B)  It has increased oxygen binding affinity relative to Hb A 
C)  It is less soluble than Hb A 
D)  It is dominant to Hb A 
E)  Therapeutic approaches have been highly successful in alleviating phenotypes associated with Hb S

The complete absence of a globin production gives rise to which phenotype?

This region regulates the switching of the b-like globin chains during development.

Which of the following statements is true regarding the a1 and a2 globin chains?

The HbA form of hemoglobin consists of which globin chains?

Which of the following statements is true of the sickle cell trait-associated form of hemoglobin,Hb S?

The History and Impact of Genetics in Medicine

The Cellular and Molecular Basis of Inheritance

Chromosomes and Cell Division

Dna Technology and Applications

Mapping and Identifying Genes for Monogenic Disorders

Developmental Genetics

Patterns of Inheritance

Population and Mathematical Genetics

Polygenic and Multifactorial Inheritance

Biochemical Genetics

Pharmacogenetics

Immunogenetics

Cancer Genetics

Genetic Factors in Common Diseases

Congenital Abnormalities and Dysmorphic Syndromes

Genetic Counseling

Chromosome Disorders

Single-Gene Disorders

Screening for Genetic Disease

Prenatal Testing and Reproductive Genetics

Risk Calculation

Treatment of Genetic Disease

Ethical and Legal Issues in Medical Genetics

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Exam 10: Hemoglobin and the Hemoglobinopathies

The complete absence of a globin production gives rise to which phenotype?

This region regulates the switching of the b-like globin chains during development.

Which of the following statements is true regarding the a1 and a2 globin chains?

The HbA form of hemoglobin consists of which globin chains?

Which of the following statements is true of the sickle cell trait-associated form of hemoglobin,Hb S?

The History and Impact of Genetics in Medicine

The Cellular and Molecular Basis of Inheritance

Chromosomes and Cell Division

Dna Technology and Applications

Mapping and Identifying Genes for Monogenic Disorders

Developmental Genetics

Patterns of Inheritance

Population and Mathematical Genetics

Polygenic and Multifactorial Inheritance

Biochemical Genetics

Pharmacogenetics

Immunogenetics

Cancer Genetics

Genetic Factors in Common Diseases

Congenital Abnormalities and Dysmorphic Syndromes

Genetic Counseling

Chromosome Disorders

Single-Gene Disorders

Screening for Genetic Disease

Prenatal Testing and Reproductive Genetics

Risk Calculation

Treatment of Genetic Disease

Ethical and Legal Issues in Medical Genetics

Filters