Exam 11: Chromosome Structure

Histone deacetylase (HDAC)inhibitors are commonly used as mood stabilizers or in the treatment of neurodegenerative diseases.What effect would a HDAC inhibitor have on the target cells?

How many pairs of chromosomes are found in a typical human somatic cell's karyotype?

Nucleosome displacement during transcription initiation is referred to as what?

Given what you know about coat color in cats,list the possible genotypes for these individuals: • orange male • orange female • black male • black female • tortoiseshell

What is meant by the "beads on a string" model of chromatin?

Chromosome condensation compacts the chromosomes so they can be efficiently separated at which phase of mitosis?

A bacterium inherits a mutation that renders its topoisomerase enzyme nonfunctional.What phenotype would you expect to see in this bacterium?

You are attempting to isolate cells for your karyotype,and you find one cell in each of the phases (prophase,metaphase,anaphase,and telophase).Which one is best suited for a karyotype?

What molecular interaction allows histones to interact with DNA?

How might a thermophilic bacterium use chromosome structure to protect against heat-induced DNA degradation?

If you want to prevent chromatin loops from being anchored to the chromosome scaffold,which regions of the DNA would you target?