Question 1

The specific array of alleles making up a set of linked genes on a single chromosome is called a ________.

Accepted Answer

haplotype

Question 2

Refer to this map to answer the following questions:
   
a) What is the distance between gene E and gene F?
b) Assuming I = 0,what is the probability of no crossovers between gene D and gene E?
c) Assuming I = 0,what is the probability of no crossovers between gene E and gene F?
d) Considering both gene pairs,what is the proportion of nonrecombinant gametes?
e) What is the predicted frequency of each parental gamete (DEF/def)?
f) What is the recombination frequency between gene D and gene E?
g) What is the recombination frequency between gene E and gene F?
h) What is the frequency of two single recombinant gametes between genes D and E?
i) What is the frequency of two single recombinant gametes between genes E and F?
j) What is the frequency of each of the double-recombinant gametes,DeF and dEf?
k) Fill in the blanks below to prove that the sum of the frequencies of the eight predicted gamete genotypes is equal to 1.0:
_______ + _______ + _______ + _______ + _______ + _______ + _______ + _______ = 1
DEF def Def dEF DEf deF DeF dEf

Accepted Answer

a) 12 cM
b) 92%
c) 88%
d) (0.92)(0.88)= 0.8096
e) (0.5)(0.8096)= 0.4048
f) 8%
g) 12%
h) (0.08)(0.88)(0.5)= 0.0352
i) (0.12)(0.92)(0.5)= 0.0552
j) (0.08)(0.12)(0.5)= 0.0048
k) 0.4048 + 0.048 + 0.0352 + 0.0352 + 0.0552 + 0.0552 + 0.0048 + 0.0048 = 1

Question 3

For a given haplotype,the frequencies of alleles for gene Y are Y = 0.65 and Y' = 0.35,and the frequencies at gene Z are Z = 0.25 and Z' = 0.75.What is the predicted frequency of the Y'Z' haplotype?

Accepted Answer

A) 0.16 
B) 0.26 
C) 0.74 
D) 0.84 
E) 1.1 
A) 0.16 
B) 0.26 
C) 0.74 
D) 0.84 
E) 1.1 B

Question 4

Ascospores in yeast are not arranged in a particular order.Thus,the four haploid ascospores contained within a yeast ascus are known as what?

Accepted Answer

The answer of Ascospores in yeast are not arranged in...

Question 5

Describe why allelic phase is a major obstacle in mapping human genes.

Accepted Answer

Allelic phase is the arrangement of diff

Question 6

In a two-point test-cross analysis,a dihybrid F₁ fly is crossed to a

Accepted Answer

A) pure-breeding mate with a dominant phenotype (AAB
B) . 
B) pure-breeding mate with a recessive phenotype (aabb). 
C) heterozygote mate (AaBb). 
D) mate that is dominant for one gene and recessive for the other (AAbb or aaB
B) . 
E) second dihybrid F₁ fly (sibling cross). 
A) pure-breeding mate with a dominant phenotype (AAB
B) . 
B) pure-breeding mate with a recessive phenotype (aabb). 
C) heterozygote mate (AaBb). 
D) mate that is dominant for one gene and recessive for the other (AAbb or aaB
B) . 
E) second dihybrid F₁ fly (sibling cross).

Question 7

Morgan realized that Bateson and Punnett had detected genetic linkage but couldn't explain their results because they performed the wrong cross.What type of cross did Morgan use for the analysis of genetic linkage of autosomal genes in Drosophila?

Accepted Answer

two-point

Question 8

The products of meiosis yield the following results:
PD = 1200 TT = 750 NPD = 50
What is the recombination frequency?

Accepted Answer

RF = [(NPD + 1/2TT)/

Question 9

What is the highest possible frequency of recombination between linked genes that can be generated by any type of crossover event?

Accepted Answer

The answer of What is the highest possible frequency of...

Question 10

In a two-point test-cross analysis,what are the "two points" being tested?

Accepted Answer

The answer of In a two-point test-cross analysis,what are the...

Question 11

Genetic linkage leads to the production of a significantly greater than expected number of gametes containing chromosomes with

Accepted Answer

A) allele combinations that are different from parental combinations. 
B) parental combinations of alleles. 
C) mutant alleles. 
D) dominant alleles. 
E) recessive alleles. 
A) allele combinations that are different from parental combinations. 
B) parental combinations of alleles. 
C) mutant alleles. 
D) dominant alleles. 
E) recessive alleles.

Question 12

If you are given a recombination frequency of 34% between genes X and Y and 27% between X and Z,can you predict the order of the three genes?

Accepted Answer

A) Yes;the order is X-Z-Y. 
B) Yes;the order is X-Y-Z. 
C) Yes;the order is Z-X-Y. 
D) No;based on this data alone,the order could be Z-Y-X or X-Y-Z. 
E) No;based on this data alone,the order could be X-Z-Y or Z-X-Y. 
A) Yes;the order is X-Z-Y. 
B) Yes;the order is X-Y-Z. 
C) Yes;the order is Z-X-Y. 
D) No;based on this data alone,the order could be Z-Y-X or X-Y-Z. 
E) No;based on this data alone,the order could be X-Z-Y or Z-X-Y.

Question 13

Syntenic genes can assort independently when

Accepted Answer

A) they are very close together on a chromosome. 
B) they are located on different chromosomes. 
C) crossing over occurs rarely between the genes. 
D) they are far apart on a chromosome and crossing over occurs frequently between the genes. 
E) they are far apart on a chromosome and crossing over occurs very rarely between the genes. 
A) they are very close together on a chromosome. 
B) they are located on different chromosomes. 
C) crossing over occurs rarely between the genes. 
D) they are far apart on a chromosome and crossing over occurs frequently between the genes. 
E) they are far apart on a chromosome and crossing over occurs very rarely between the genes.

Question 14

How is Newton Morton's statistical method helpful for calculating the overall probability of genetic linkage when allelic phase is unknown?

Accepted Answer

Morton's method determines whether genet

Question 15

What unit of physical distance between genes on a chromosome provides a convenient way to link the recombination frequencies for linked genes with their positions and order along a chromosome?

Accepted Answer

map unit (

Question 16

What is the relationship between linked genes and syntenic genes? Are syntenic genes always linked,or are linked genes always syntenic? Describe what is meant by each term.

Accepted Answer

Linked genes are always inherited togeth

Question 17

Recombination analysis allows for the mapping of genes because the frequency of crossing over is proportional to what?

Accepted Answer

distance b

Question 18

There are three genes located in the gene order A-B-C on a chromosome.Would you expect the recombination frequency to be higher between A and B or A and C?

Accepted Answer

higher fro

Question 19

What type of test would you use to determine the relative order of more than two genes?

Accepted Answer

three-poin

Question 20

What would a Lod score of 3.2 tell you about genetic linkage? What information does the Θ value tell you?

Accepted Answer

Scores of greater than 3.0 pro

Exam 5: Genetic Linkage and Mapping in Eukaryotes

The specific array of alleles making up a set of linked genes on a single chromosome is called a ________.

For a given haplotype,the frequencies of alleles for gene Y are Y = 0.65 and Y' = 0.35,and the frequencies at gene Z are Z = 0.25 and Z' = 0.75.What is the predicted frequency of the Y'Z' haplotype?

Ascospores in yeast are not arranged in a particular order.Thus,the four haploid ascospores contained within a yeast ascus are known as what?

Describe why allelic phase is a major obstacle in mapping human genes.

In a two-point test-cross analysis,a dihybrid F₁ fly is crossed to a

Morgan realized that Bateson and Punnett had detected genetic linkage but couldn't explain their results because they performed the wrong cross.What type of cross did Morgan use for the analysis of genetic linkage of autosomal genes in Drosophila?

The products of meiosis yield the following results: PD = 1200 TT = 750 NPD = 50 What is the recombination frequency?

What is the highest possible frequency of recombination between linked genes that can be generated by any type of crossover event?

In a two-point test-cross analysis,what are the "two points" being tested?

Genetic linkage leads to the production of a significantly greater than expected number of gametes containing chromosomes with

If you are given a recombination frequency of 34% between genes X and Y and 27% between X and Z,can you predict the order of the three genes?

Syntenic genes can assort independently when

How is Newton Morton's statistical method helpful for calculating the overall probability of genetic linkage when allelic phase is unknown?

What unit of physical distance between genes on a chromosome provides a convenient way to link the recombination frequencies for linked genes with their positions and order along a chromosome?

What is the relationship between linked genes and syntenic genes? Are syntenic genes always linked,or are linked genes always syntenic? Describe what is meant by each term.

Recombination analysis allows for the mapping of genes because the frequency of crossing over is proportional to what?

There are three genes located in the gene order A-B-C on a chromosome.Would you expect the recombination frequency to be higher between A and B or A and C?

What type of test would you use to determine the relative order of more than two genes?

What would a Lod score of 3.2 tell you about genetic linkage? What information does the Θ value tell you?

The Molecular Basis of Heredity, Variation, and Evolution

Transmission Genetics

Cell Division and Chromosome Heredity

Gene Interaction

Genetic Analysis and Mapping in Bacteria and Bacteriophage

DNA Structure and Replication

Molecular Biology and Transcription and Rna Processing

The Molecular Biology of Translation

The Integration of Genetic Approaches: Understanding Sickle Cell Disease

Chromosome Structure

Gene Mutation, DNA Repair, and Homologous Recombination

Chromosome Aberrations and Transposition

Regulation of Gene Expression in Bacteria and Bacteriophage

Regulation of Gene Expression in Eukaryotes

Forward Genetics and Recombinant DNA Technology

Applications of Recombinant DNA Technology and Reverse Genetics

Genomics: Genetics From a Whole-Genome Perspective

Cytoplasmic Inheritance and the Evolution of Organelle Genomes

Developmental Genetics

Genetic Analysis of Quantitative Traits

Population Genetics and Evolution

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