Question 1

Risk of transmission of herpes simplex infection is greatest in which of the following clinical stages?

Accepted Answer

A) Latent stage with shedding 
B) Latent stage without shedding 
C) Vesicular stage (early lesion, 1 to 3 days) 
D) Ulcerative stage (mid lesion, 4 to 10 days) 
E) Ulcer re-epithelialization (late lesion, 11 to 14 days) 
A) Latent stage with shedding 
B) Latent stage without shedding 
C) Vesicular stage (early lesion, 1 to 3 days) 
D) Ulcerative stage (mid lesion, 4 to 10 days) 
E) Ulcer re-epithelialization (late lesion, 11 to 14 days)

Question 2

Secondary varicella-zoster virus infections:

Accepted Answer

A) May signal an underlying lymphoma 
B) Are more prevalent in immunocompromised patients 
C) Result from virus reactivation 
D) Are painful 
E) All of the above 
A) May signal an underlying lymphoma 
B) Are more prevalent in immunocompromised patients 
C) Result from virus reactivation 
D) Are painful 
E) All of the above

Question 3

Which of the following conditions exhibits subepithelial separation microscopically?

Accepted Answer

A) Pemphigus vulgaris 
B) Mucous membrane pemphigoid 
C) Aphthous stomatitis 
D) Secondary herpes simplex 
E) None of the above 
A) Pemphigus vulgaris 
B) Mucous membrane pemphigoid 
C) Aphthous stomatitis 
D) Secondary herpes simplex 
E) None of the above

Question 4

Keratinocyte dysadhesion, also known as acantholysis, due to desmosome weakening by autoantibodies is the disease mechanism attributed to which of the following?

Accepted Answer

A) Epidermolysis bullosa 
B) Mucous membrane pemphigoid 
C) Pemphigus vulgaris 
D) Herpes simplex infections 
E) None of the above 
A) Epidermolysis bullosa 
B) Mucous membrane pemphigoid 
C) Pemphigus vulgaris 
D) Herpes simplex infections 
E) None of the above

Question 5

Unilateral distribution of cutaneous or mucosal ulcers followed by prolonged post-lesional pain would be associated with which of the following?

Accepted Answer

A) Primary herpes simplex infection 
B) Secondary herpes simplex infections 
C) Secondary syphilis 
D) Zoster 
E) Hand-foot-and-mouth disease 
A) Primary herpes simplex infection 
B) Secondary herpes simplex infections 
C) Secondary syphilis 
D) Zoster 
E) Hand-foot-and-mouth disease

Question 6

An 80-year-old woman presents with multiple ulcers of her attached gingiva of 6 weeks' duration. She also has persistent conjunctivitis. These signs taken together would be most suggestive of which of the following?

Accepted Answer

A) Pemphigus vulgaris 
B) Mucous membrane pemphigoid 
C) Behçet's syndrome 
D) Erythema multiforme 
E) Chronic lupus erythematosus 
A) Pemphigus vulgaris 
B) Mucous membrane pemphigoid 
C) Behçet's syndrome 
D) Erythema multiforme 
E) Chronic lupus erythematosus

Question 7

Direct immunofluorescence is done with the patient's:

Accepted Answer

A) Saliva 
B) Serum 
C) Tissue 
D) Cytologic smear 
E) Red cells 
A) Saliva 
B) Serum 
C) Tissue 
D) Cytologic smear 
E) Red cells

Question 8

A 16-year-old girl developed multiple recurrent fluid-filled lesions of the vermilion of her lower lip. This has happened before in the same site. She has no eye, genital, or cutaneous lesions. A cytology smear contained numerous multinucleated cells. The diagnosis is:

Accepted Answer

A) Pemphigus vulgaris 
B) Mucous membrane pemphigoid 
C) Lichen planus 
D) Aphthous stomatitis 
E) Herpes simplex infection 
A) Pemphigus vulgaris 
B) Mucous membrane pemphigoid 
C) Lichen planus 
D) Aphthous stomatitis 
E) Herpes simplex infection

Question 9

Systemic corticosteroids can affect many metabolic processes. Which of the following effects of prednisone is regarded as therapeutic when prescribed for patients with pemphigus vulgaris and mucous membrane pemphigoid?

Accepted Answer

A) Gluconeogenesis 
B) Potentiation of vasopressors 
C) Suppression of pituitary-adrenal axis 
D) Sodium resorption 
E) Immunosuppression 
A) Gluconeogenesis 
B) Potentiation of vasopressors 
C) Suppression of pituitary-adrenal axis 
D) Sodium resorption 
E) Immunosuppression

Question 10

Which of the following is known to trigger recurrent herpes simplex infections?

Accepted Answer

A) Exposure to cold temperatures 
B) Immunodeficiency 
C) Stress 
D) Ultraviolet light exposure 
E) All the above 
A) Exposure to cold temperatures 
B) Immunodeficiency 
C) Stress 
D) Ultraviolet light exposure 
E) All the above

Question 11

Intercellular deposits of IgG are consistently found in oral epithelium in which of the following?

Accepted Answer

A) Cicatricial pemphigoid 
B) Lichen planus 
C) Pemphigus vulgaris 
D) Stevens-Johnson syndrome 
E) Aphthous ulcers 
A) Cicatricial pemphigoid 
B) Lichen planus 
C) Pemphigus vulgaris 
D) Stevens-Johnson syndrome 
E) Aphthous ulcers

Question 12

Herpes whitlow is now rarely seen in dental practitioners because:

Accepted Answer

A) Most dental personnel have protective circulating antibodies to HSV 
B) Dental personnel are vaccinated against HSV 
C) Dental personnel wear gloves when practicing 
D) Acyclovir prevents its occurrence 
E) None of the above 
A) Most dental personnel have protective circulating antibodies to HSV 
B) Dental personnel are vaccinated against HSV 
C) Dental personnel wear gloves when practicing 
D) Acyclovir prevents its occurrence 
E) None of the above

Question 13

Which of the following herpes viruses has been associated with the development of carcinoma of the nasopharynx?

Accepted Answer

A) VZV (varicella-zoster) 
B) HSV (herpes simplex), type 1 
C) HSV (herpes simplex), type 2 
D) CMV (cytomegalovirus) 
E) Epstein-Barr virus 
A) VZV (varicella-zoster) 
B) HSV (herpes simplex), type 1 
C) HSV (herpes simplex), type 2 
D) CMV (cytomegalovirus) 
E) Epstein-Barr virus

Question 14

Which of the following frequently appears in the mouth before expressing itself in the skin?

Accepted Answer

A) Pemphigus vulgaris 
B) Bullous pemphigoid 
C) Minor aphthous ulcers 
D) Major aphthous ulcers 
E) None of the above 
A) Pemphigus vulgaris 
B) Bullous pemphigoid 
C) Minor aphthous ulcers 
D) Major aphthous ulcers 
E) None of the above

Question 15

The keratinocyte desmosome complex is the pathologic target in which of the following diseases?

Accepted Answer

A) Discoid lupus erythematosus 
B) Systemic lupus erythematosus 
C) Tuberculosis 
D) Pemphigoid 
E) None of the above 
A) Discoid lupus erythematosus 
B) Systemic lupus erythematosus 
C) Tuberculosis 
D) Pemphigoid 
E) None of the above

Question 16

Intraoral lesions that result from reactivation of sequestered herpes simplex virus occur in which of the following locations?

Accepted Answer

A) Hard palate 
B) Tongue 
C) Buccal mucosa 
D) Tonsil 
E) All the above 
A) Hard palate 
B) Tongue 
C) Buccal mucosa 
D) Tonsil 
E) All the above

Question 17

A patient seeks help for recurrent palatal pain. She presents with multiple punctate ulcers in the hard palate that were preceded by tiny blisters. Her lesions typically heal in about 2 weeks and reappear during stressful times. She has:

Accepted Answer

A) Aphthous ulcers 
B) Recurrent primary herpes 
C) Recurrent secondary herpes 
D) Erythema multiforme 
E) Discoid lupus 
A) Aphthous ulcers 
B) Recurrent primary herpes 
C) Recurrent secondary herpes 
D) Erythema multiforme 
E) Discoid lupus

Question 18

A patient who has fever, malaise, arthralgia, headache, and oral and perioral ulcers most likely would have which of the following?

Accepted Answer

A) Secondary herpes simplex infection 
B) Primary herpes simplex infection 
C) Shingles 
D) Herpangina 
E) Secondary syphilis 
A) Secondary herpes simplex infection 
B) Primary herpes simplex infection 
C) Shingles 
D) Herpangina 
E) Secondary syphilis

Question 19

Generally, corticosteroids are contraindicated in the treatment of which of the following conditions?

Accepted Answer

A) Chronic traumatic ulcers 
B) Pemphigus vulgaris 
C) Herpetiform aphthous ulcers 
D) Hand-foot-and-mouth disease 
E) Mucous membrane pemphigoid 
A) Chronic traumatic ulcers 
B) Pemphigus vulgaris 
C) Herpetiform aphthous ulcers 
D) Hand-foot-and-mouth disease 
E) Mucous membrane pemphigoid

Question 20

A middle-aged man developed multiple flat ulcers in his palate, tongue, and buccal mucosa. The lesions measured approximately 1 cm in diameter and were preceded briefly by bullae. The lesions have been persistent for 6 weeks. He has no skin, eye, or genital lesions. Biopsy shows acantholysis with intraepithelial separation. He most likely has:

Accepted Answer

A) Erythema multiforme 
B) Discoid lupus erythematosus 
C) Primary herpes simplex infection 
D) Mucous membrane pemphigoid 
E) None of the above 
A) Erythema multiforme 
B) Discoid lupus erythematosus 
C) Primary herpes simplex infection 
D) Mucous membrane pemphigoid 
E) None of the above

Risk of transmission of herpes simplex infection is greatest in which of the following clinical stages?

Secondary varicella-zoster virus infections:

Which of the following conditions exhibits subepithelial separation microscopically?

Keratinocyte dysadhesion, also known as acantholysis, due to desmosome weakening by autoantibodies is the disease mechanism attributed to which of the following?

Unilateral distribution of cutaneous or mucosal ulcers followed by prolonged post-lesional pain would be associated with which of the following?

An 80-year-old woman presents with multiple ulcers of her attached gingiva of 6 weeks' duration. She also has persistent conjunctivitis. These signs taken together would be most suggestive of which of the following?

Direct immunofluorescence is done with the patient's:

A 16-year-old girl developed multiple recurrent fluid-filled lesions of the vermilion of her lower lip. This has happened before in the same site. She has no eye, genital, or cutaneous lesions. A cytology smear contained numerous multinucleated cells. The diagnosis is:

Systemic corticosteroids can affect many metabolic processes. Which of the following effects of prednisone is regarded as therapeutic when prescribed for patients with pemphigus vulgaris and mucous membrane pemphigoid?

Which of the following is known to trigger recurrent herpes simplex infections?

Intercellular deposits of IgG are consistently found in oral epithelium in which of the following?

Herpes whitlow is now rarely seen in dental practitioners because:

Which of the following herpes viruses has been associated with the development of carcinoma of the nasopharynx?

Which of the following frequently appears in the mouth before expressing itself in the skin?

The keratinocyte desmosome complex is the pathologic target in which of the following diseases?

Intraoral lesions that result from reactivation of sequestered herpes simplex virus occur in which of the following locations?

A patient seeks help for recurrent palatal pain. She presents with multiple punctate ulcers in the hard palate that were preceded by tiny blisters. Her lesions typically heal in about 2 weeks and reappear during stressful times. She has:

A patient who has fever, malaise, arthralgia, headache, and oral and perioral ulcers most likely would have which of the following?

Generally, corticosteroids are contraindicated in the treatment of which of the following conditions?

Ulcerative Conditions

White Lesions

Red-Blue Lesions

Pigmented Lesions

Verrucal-Papillary Lesions

Connective Tissue Lesions

Salivary Gland Diseases

Lymphoid Lesions

Cysts of the Jaws and Neck

Odontogenic Tumors

Benign Nonodontogenic Tumors

Inflammatory Jaw Lesions

Malignancies of the Jaws

Metabolic and Genetic Diseases

Abnormalities of Teeth

Filters

Exam 1: Vesiculobullous Diseases

Risk of transmission of herpes simplex infection is greatest in which of the following clinical stages?

Secondary varicella-zoster virus infections:

Which of the following conditions exhibits subepithelial separation microscopically?

Keratinocyte dysadhesion, also known as acantholysis, due to desmosome weakening by autoantibodies is the disease mechanism attributed to which of the following?

Unilateral distribution of cutaneous or mucosal ulcers followed by prolonged post-lesional pain would be associated with which of the following?

An 80-year-old woman presents with multiple ulcers of her attached gingiva of 6 weeks' duration. She also has persistent conjunctivitis. These signs taken together would be most suggestive of which of the following?

Direct immunofluorescence is done with the patient's:

A 16-year-old girl developed multiple recurrent fluid-filled lesions of the vermilion of her lower lip. This has happened before in the same site. She has no eye, genital, or cutaneous lesions. A cytology smear contained numerous multinucleated cells. The diagnosis is:

Systemic corticosteroids can affect many metabolic processes. Which of the following effects of prednisone is regarded as therapeutic when prescribed for patients with pemphigus vulgaris and mucous membrane pemphigoid?

Which of the following is known to trigger recurrent herpes simplex infections?

Intercellular deposits of IgG are consistently found in oral epithelium in which of the following?

Herpes whitlow is now rarely seen in dental practitioners because:

Which of the following herpes viruses has been associated with the development of carcinoma of the nasopharynx?

Which of the following frequently appears in the mouth before expressing itself in the skin?

The keratinocyte desmosome complex is the pathologic target in which of the following diseases?

Intraoral lesions that result from reactivation of sequestered herpes simplex virus occur in which of the following locations?

A patient seeks help for recurrent palatal pain. She presents with multiple punctate ulcers in the hard palate that were preceded by tiny blisters. Her lesions typically heal in about 2 weeks and reappear during stressful times. She has:

A patient who has fever, malaise, arthralgia, headache, and oral and perioral ulcers most likely would have which of the following?

Generally, corticosteroids are contraindicated in the treatment of which of the following conditions?

Ulcerative Conditions

White Lesions

Red-Blue Lesions

Pigmented Lesions

Verrucal-Papillary Lesions

Connective Tissue Lesions

Salivary Gland Diseases

Lymphoid Lesions

Cysts of the Jaws and Neck

Odontogenic Tumors

Benign Nonodontogenic Tumors

Inflammatory Jaw Lesions

Malignancies of the Jaws

Metabolic and Genetic Diseases

Abnormalities of Teeth

Filters