Question 1

Biopsy confirmation of mucous membrane pemphigoid can be made by which of the following?

Accepted Answer

A) Direct immunofluorescence 
B) Fite stain of tissue section 
C) Determination of serum antinuclear antibodies (ANAs) 
D) Observed response to trial dose of acyclovir 
E) None of the above 
A) Direct immunofluorescence 
B) Fite stain of tissue section 
C) Determination of serum antinuclear antibodies (ANAs) 
D) Observed response to trial dose of acyclovir 
E) None of the above A

Question 2

Ophthalmologic examination is important to rule out conjunctival lesions in patients with which of the following mucocutaneous diseases?

Accepted Answer

A) Mucous membrane pemphigoid 
B) Epidermolysis bullosa 
C) Lichen planus 
D) Herpangina 
E) Secondary syphilis 
A) Mucous membrane pemphigoid 
B) Epidermolysis bullosa 
C) Lichen planus 
D) Herpangina 
E) Secondary syphilis A

Question 3

The bullous eruption of attached gingiva mediated by autoantibodies directed against basement membrane antigens is known as:

Accepted Answer

A) Pemphigus vulgaris 
B) Lupus erythematosus 
C) Erythema multiforme 
D) Behçet's syndrome 
E) None of the above 
A) Pemphigus vulgaris 
B) Lupus erythematosus 
C) Erythema multiforme 
D) Behçet's syndrome 
E) None of the above E

Question 4

Direct immunofluorescence is a laboratory test that is effective in confirming which of the following?

Accepted Answer

A) Major aphthae 
B) Primary herpes simplex 
C) Zoster 
D) Drug allergy 
E) None of the above 
A) Major aphthae 
B) Primary herpes simplex 
C) Zoster 
D) Drug allergy 
E) None of the above

Question 5

A blistering hereditary condition typically affects the skin and mucous membranes of children. Lesions, most commonly found at pressure points, heal with scars. This condition is known as:

Accepted Answer

A) Cicatricial pemphigoid 
B) Hand-foot-and-mouth disease 
C) Measles 
D) Epidermolysis bullosa 
E) Varicella 
A) Cicatricial pemphigoid 
B) Hand-foot-and-mouth disease 
C) Measles 
D) Epidermolysis bullosa 
E) Varicella

Question 6

A 9-year-old girl presents with marked gingival inflammation and multiple small ulcers involving her vestibular mucosa, vermilion, and perioral skin. She has a fever, malaise, joint pain, and headache. She most likely has which of the following?

Accepted Answer

A) Primary herpes simplex infection 
B) Measles 
C) Herpangina 
D) Mucous membrane pemphigoid 
E) Acute lupus erythematosus 
A) Primary herpes simplex infection 
B) Measles 
C) Herpangina 
D) Mucous membrane pemphigoid 
E) Acute lupus erythematosus

Question 7

Microscopic evidence of active herpes simplex infection appears as multinucleation in which of the following cells?

Accepted Answer

A) Langerhans cells 
B) Macrophages 
C) Keratinocytes 
D) Schwann cells 
E) None of the above 
A) Langerhans cells 
B) Macrophages 
C) Keratinocytes 
D) Schwann cells 
E) None of the above

Question 8

A 67-year-old woman presents with multiple persistent large ulcers of her gingiva and buccal mucosa. Biopsy of tissue adjacent to the ulcers shows epithelial separation from submucosa through the level of the basement membrane. This is suggestive of which of the following?

Accepted Answer

A) Major aphthous ulcers 
B) Secondary syphilis 
C) Secondary herpes simplex infection 
D) Pemphigus vulgaris 
E) Mucous membrane pemphigoid 
A) Major aphthous ulcers 
B) Secondary syphilis 
C) Secondary herpes simplex infection 
D) Pemphigus vulgaris 
E) Mucous membrane pemphigoid

Question 9

Herpes simplex labialis is due to reactivation of a virus that resides in which of the following sites during latent periods?

Accepted Answer

A) Basement membrane of the lip 
B) Trigeminal ganglion 
C) Submucosal macrophages in the lip 
D) Epithelium of the vermilion 
E) None of the above 
A) Basement membrane of the lip 
B) Trigeminal ganglion 
C) Submucosal macrophages in the lip 
D) Epithelium of the vermilion 
E) None of the above

Question 10

Which of the following features would help separate pemphigus from primary herpes simplex infection?

Accepted Answer

A) Systemic symptoms 
B) Duration of disease 
C) Persistence of disease 
D) Size of lesions and their distribution 
E) All the above 
A) Systemic symptoms 
B) Duration of disease 
C) Persistence of disease 
D) Size of lesions and their distribution 
E) All the above

Question 11

Relative to pemphigus vulgaris and mucous membrane pemphigoid, which of the following is incorrect?

Accepted Answer

A) IgG can be demonstrated in tissue biopsies of both diseases. 
B) Both present as ulcers preceded by blisters. 
C) Both respond to treatment with corticosteroids. 
D) Both are self-limited. 
E) Both can affect the same intraoral sites. 
A) IgG can be demonstrated in tissue biopsies of both diseases. 
B) Both present as ulcers preceded by blisters. 
C) Both respond to treatment with corticosteroids. 
D) Both are self-limited. 
E) Both can affect the same intraoral sites.

Question 12

The childhood disease that features a maculopapular rash, predominantly of the head, neck, and trunk, preceded by tiny ulcers of the buccal mucosa is known as:

Accepted Answer

A) Herpangina 
B) Measles 
C) Varicella 
D) Primary herpes gingivostomatitis 
E) Erythema multiforme 
A) Herpangina 
B) Measles 
C) Varicella 
D) Primary herpes gingivostomatitis 
E) Erythema multiforme

Question 13

Which of the following physicians' names (eponym) is used in association with the oral herald sign of rubeola?

Accepted Answer

A) Tzanck 
B) Reiter 
C) Nikolsky 
D) Behçet 
E) Koplik 
A) Tzanck 
B) Reiter 
C) Nikolsky 
D) Behçet 
E) Koplik

Question 14

A patient presented with painful ulcerative lesions in his buccal mucosae, gingiva, and tongue. The lesions were subsequently proven to be pemphigus vulgaris on biopsy. Which of the following treatment regimens would be most effective in controlling this patient's disease?

Accepted Answer

A) Systemic acyclovir 
B) Topical corticosteroids 
C) Systemic corticosteroids 
D) Systemic antibiotics 
E) Systemic antifungals 
A) Systemic acyclovir 
B) Topical corticosteroids 
C) Systemic corticosteroids 
D) Systemic antibiotics 
E) Systemic antifungals

Question 15

The Tzanck cells in pemphigus vulgaris result from:

Accepted Answer

A) Acantholysis 
B) Acanthosis 
C) Intercellular edema 
D) Intracellular edema 
E) Mucous extravasation 
A) Acantholysis 
B) Acanthosis 
C) Intercellular edema 
D) Intracellular edema 
E) Mucous extravasation

Question 16

Topical corticosteroids used orally for long periods and/or at high potency can cause which of the following oral problems?

Accepted Answer

A) Lichen planus 
B) Candidiasis 
C) Cancer 
D) Aphthous ulcers 
E) Herpes simplex labialis 
A) Lichen planus 
B) Candidiasis 
C) Cancer 
D) Aphthous ulcers 
E) Herpes simplex labialis

Question 17

Multiple self-limited ulcers are characteristically seen in the pharynx of patients with which of the following diseases?

Accepted Answer

A) Herpangina 
B) Hand-foot-and-mouth disease 
C) Measles 
D) Secondary herpes simplex infections 
E) Primary syphilis 
A) Herpangina 
B) Hand-foot-and-mouth disease 
C) Measles 
D) Secondary herpes simplex infections 
E) Primary syphilis

Question 18

During active disease states, circulating autoantibodies directed toward a protein known as desmoglein 3 in skin and mucosa epithelium are seen in which of the following?

Accepted Answer

A) Aphthous ulcers 
B) Behçet's syndrome 
C) Erythema multiforme 
D) Pemphigus vulgaris 
E) None of the above 
A) Aphthous ulcers 
B) Behçet's syndrome 
C) Erythema multiforme 
D) Pemphigus vulgaris 
E) None of the above

Question 19

All the following would be considered iatrogenic injuries except:

Accepted Answer

A) Amalgam tattoo 
B) Saliva ejector injury 
C) Chemical burn following medication of cavity preparation 
D) Ulceration resulting from traumatic dental impression 
E) Zoster precipitated by lymphoma 
A) Amalgam tattoo 
B) Saliva ejector injury 
C) Chemical burn following medication of cavity preparation 
D) Ulceration resulting from traumatic dental impression 
E) Zoster precipitated by lymphoma

Question 20

A 45-year-old woman presents with a 0.5 ´ 1 cm painless purple patch on her mandibular gingiva. Duration was unknown. All of the following might be included in a clinical differential diagnosis except:

Accepted Answer

A) Melanoma 
B) Kaposi's sarcoma 
C) Erythroplakia 
D) Secondary herpes 
E) Vascular malformation 
A) Melanoma 
B) Kaposi's sarcoma 
C) Erythroplakia 
D) Secondary herpes 
E) Vascular malformation

Biopsy confirmation of mucous membrane pemphigoid can be made by which of the following?

Ophthalmologic examination is important to rule out conjunctival lesions in patients with which of the following mucocutaneous diseases?

The bullous eruption of attached gingiva mediated by autoantibodies directed against basement membrane antigens is known as:

Direct immunofluorescence is a laboratory test that is effective in confirming which of the following?

A blistering hereditary condition typically affects the skin and mucous membranes of children. Lesions, most commonly found at pressure points, heal with scars. This condition is known as:

A 9-year-old girl presents with marked gingival inflammation and multiple small ulcers involving her vestibular mucosa, vermilion, and perioral skin. She has a fever, malaise, joint pain, and headache. She most likely has which of the following?

Microscopic evidence of active herpes simplex infection appears as multinucleation in which of the following cells?

A 67-year-old woman presents with multiple persistent large ulcers of her gingiva and buccal mucosa. Biopsy of tissue adjacent to the ulcers shows epithelial separation from submucosa through the level of the basement membrane. This is suggestive of which of the following?

Herpes simplex labialis is due to reactivation of a virus that resides in which of the following sites during latent periods?

Which of the following features would help separate pemphigus from primary herpes simplex infection?

Relative to pemphigus vulgaris and mucous membrane pemphigoid, which of the following is incorrect?

The childhood disease that features a maculopapular rash, predominantly of the head, neck, and trunk, preceded by tiny ulcers of the buccal mucosa is known as:

Which of the following physicians' names (eponym) is used in association with the oral herald sign of rubeola?

A patient presented with painful ulcerative lesions in his buccal mucosae, gingiva, and tongue. The lesions were subsequently proven to be pemphigus vulgaris on biopsy. Which of the following treatment regimens would be most effective in controlling this patient's disease?

The Tzanck cells in pemphigus vulgaris result from:

Topical corticosteroids used orally for long periods and/or at high potency can cause which of the following oral problems?

Multiple self-limited ulcers are characteristically seen in the pharynx of patients with which of the following diseases?

During active disease states, circulating autoantibodies directed toward a protein known as desmoglein 3 in skin and mucosa epithelium are seen in which of the following?

All the following would be considered iatrogenic injuries except:

A 45-year-old woman presents with a 0.5 ´ 1 cm painless purple patch on her mandibular gingiva. Duration was unknown. All of the following might be included in a clinical differential diagnosis except:

Ulcerative Conditions

White Lesions

Red-Blue Lesions

Pigmented Lesions

Verrucal-Papillary Lesions

Connective Tissue Lesions

Salivary Gland Diseases

Lymphoid Lesions

Cysts of the Jaws and Neck

Odontogenic Tumors

Benign Nonodontogenic Tumors

Inflammatory Jaw Lesions

Malignancies of the Jaws

Metabolic and Genetic Diseases

Abnormalities of Teeth

Filters

Exam 1: Vesiculobullous Diseases

Biopsy confirmation of mucous membrane pemphigoid can be made by which of the following?

Ophthalmologic examination is important to rule out conjunctival lesions in patients with which of the following mucocutaneous diseases?

The bullous eruption of attached gingiva mediated by autoantibodies directed against basement membrane antigens is known as:

Direct immunofluorescence is a laboratory test that is effective in confirming which of the following?

A blistering hereditary condition typically affects the skin and mucous membranes of children. Lesions, most commonly found at pressure points, heal with scars. This condition is known as:

A 9-year-old girl presents with marked gingival inflammation and multiple small ulcers involving her vestibular mucosa, vermilion, and perioral skin. She has a fever, malaise, joint pain, and headache. She most likely has which of the following?

Microscopic evidence of active herpes simplex infection appears as multinucleation in which of the following cells?

A 67-year-old woman presents with multiple persistent large ulcers of her gingiva and buccal mucosa. Biopsy of tissue adjacent to the ulcers shows epithelial separation from submucosa through the level of the basement membrane. This is suggestive of which of the following?

Herpes simplex labialis is due to reactivation of a virus that resides in which of the following sites during latent periods?

Which of the following features would help separate pemphigus from primary herpes simplex infection?

Relative to pemphigus vulgaris and mucous membrane pemphigoid, which of the following is incorrect?

The childhood disease that features a maculopapular rash, predominantly of the head, neck, and trunk, preceded by tiny ulcers of the buccal mucosa is known as:

Which of the following physicians' names (eponym) is used in association with the oral herald sign of rubeola?

A patient presented with painful ulcerative lesions in his buccal mucosae, gingiva, and tongue. The lesions were subsequently proven to be pemphigus vulgaris on biopsy. Which of the following treatment regimens would be most effective in controlling this patient's disease?

The Tzanck cells in pemphigus vulgaris result from:

Topical corticosteroids used orally for long periods and/or at high potency can cause which of the following oral problems?

Multiple self-limited ulcers are characteristically seen in the pharynx of patients with which of the following diseases?

During active disease states, circulating autoantibodies directed toward a protein known as desmoglein 3 in skin and mucosa epithelium are seen in which of the following?

All the following would be considered iatrogenic injuries except:

A 45-year-old woman presents with a 0.5 ´ 1 cm painless purple patch on her mandibular gingiva. Duration was unknown. All of the following might be included in a clinical differential diagnosis except:

Ulcerative Conditions

White Lesions

Red-Blue Lesions

Pigmented Lesions

Verrucal-Papillary Lesions

Connective Tissue Lesions

Salivary Gland Diseases

Lymphoid Lesions

Cysts of the Jaws and Neck

Odontogenic Tumors

Benign Nonodontogenic Tumors

Inflammatory Jaw Lesions

Malignancies of the Jaws

Metabolic and Genetic Diseases

Abnormalities of Teeth

Filters