Question 1

Which will be the main energy-producing degradation pathway for E.coli being grown on a medium where gluconate is the only carbon source?

Accepted Answer

A) Embden-Meyeroff-Parnas. 
B) Entner-Doudoroff. 
C) Pentose phosphate. 
D) Gycolytic. 
A) Embden-Meyeroff-Parnas. 
B) Entner-Doudoroff. 
C) Pentose phosphate. 
D) Gycolytic.

Question 2

Lactic acid produced by certain bacteria is used to curdle milk during cheese-making.

Accepted Answer

A) True 
 B)False

Question 3

Phosphofructokinase I deficiency results in

Accepted Answer

A) an overproduction of Fructose 6-phosphate. 
B) an overproduction of Fructose 1,6-bisphosphate. 
C) fructose 1,6-bisphosphate deficiency. 
D) A and C only. 
E) All of the above. 
A) an overproduction of Fructose 6-phosphate. 
B) an overproduction of Fructose 1,6-bisphosphate. 
C) fructose 1,6-bisphosphate deficiency. 
D) A and C only. 
E) All of the above.

Question 4

How would the liver normally respond under condition of high glucose?

Accepted Answer

A) Phosphorylating glucose for entry into the glycolytic pathway. 
B) Saturating glucokinase with glucose. 
C) Phosphorylating glucose for entry into the glycogen synthesis pathways. 
D) A and B only. 
E) A and C only. 
A) Phosphorylating glucose for entry into the glycolytic pathway. 
B) Saturating glucokinase with glucose. 
C) Phosphorylating glucose for entry into the glycogen synthesis pathways. 
D) A and B only. 
E) A and C only.

Question 5

Insulin increases the capacity of a cell to transport glucose by

Accepted Answer

A) forming more GLUT 4 vesicles. 
B) stimulating hexokinase. 
C) stimulating GLUTs 1,3 and others of the GLUT family. 
D) stimulating GLUT 4 vesicles to fuse with the plasma membrane. 
A) forming more GLUT 4 vesicles. 
B) stimulating hexokinase. 
C) stimulating GLUTs 1,3 and others of the GLUT family. 
D) stimulating GLUT 4 vesicles to fuse with the plasma membrane.

Question 6

Arsenate

Accepted Answer

A) competes with NAD+ for the binding site in 1,3-bisphosphoglycerate. 
B) competes with phosphate for its binding site in glyceraldehyde 3-phosphate dehydrogenase. 
C) produces a stable analog of 1,3-bisphosphoglycerate. 
D) All of the above. 
A) competes with NAD+ for the binding site in 1,3-bisphosphoglycerate. 
B) competes with phosphate for its binding site in glyceraldehyde 3-phosphate dehydrogenase. 
C) produces a stable analog of 1,3-bisphosphoglycerate. 
D) All of the above.

Question 7

Under what situation might lactic acidosis occur?

Accepted Answer

A) Lactate dehydrogenase is inactive. 
B) Transport of glucose into cells is accelerated. 
C) Oxygen supply to tissues is inadequate. 
D) PFK-1 is over-activated. 
A) Lactate dehydrogenase is inactive. 
B) Transport of glucose into cells is accelerated. 
C) Oxygen supply to tissues is inadequate. 
D) PFK-1 is over-activated.

Question 8

Glucagon triggers the adenylate cyclase signally pathway.This activates protein kinase A which phosphorylates serine residues.

Accepted Answer

A) True 
 B)False

Question 9

PFK-2 and fructose 2,6-bisphosphatase are two names for the same enzyme.The name PFK-2 is used for the enzyme's catalysis of the phosphorylation of fructose 6-phosphate to fructose 2,6-bisphosphate.The name fructose 2,6-bisphosphatase is used for its catalysis of the reverse reaction.What is unique about this enzyme that makes it logical to use two names?

Accepted Answer

A) It is one of very few enzymes that can catalyze both the forward and reverse reactions. 
B) The enzyme is a monomer when catalyzing the phosphorylation reaction and a dimer when catalyzing the reverse reaction. 
C) The forward and reverse reactions occur in different compartments within the cell,so a different name is used for each activity. 
D) The enzyme is bifunctional.The forward and reverse reactions are catalyzed by different sites on the same enzyme. 
A) It is one of very few enzymes that can catalyze both the forward and reverse reactions. 
B) The enzyme is a monomer when catalyzing the phosphorylation reaction and a dimer when catalyzing the reverse reaction. 
C) The forward and reverse reactions occur in different compartments within the cell,so a different name is used for each activity. 
D) The enzyme is bifunctional.The forward and reverse reactions are catalyzed by different sites on the same enzyme.

Question 10

Seven of the ten reactions in the glycolytic pathway have free energy values close to zero.What does this tell us about those reactions?

Accepted Answer

A) They are near equilibrium reactions. 
B) They are not control points for pathway regulation. 
C) They are reversible reactions. 
D) All of the above. 
E) None of the above. 
A) They are near equilibrium reactions. 
B) They are not control points for pathway regulation. 
C) They are reversible reactions. 
D) All of the above. 
E) None of the above.

Question 11

Two molecules of ATP are consumed per glucose during the triose stage of glycolysis.

Accepted Answer

A) True 
 B)False

Question 12

Mutases are described as

Accepted Answer

A) polymerases that catalyze phosphoryl group transfers. 
B) isomerases that catalyze the transfer of phosphoryl groups from one part of a substrate molecule to another. 
C) forming intermediate free phosphate (Pi). 
D) All of the above. 
A) polymerases that catalyze phosphoryl group transfers. 
B) isomerases that catalyze the transfer of phosphoryl groups from one part of a substrate molecule to another. 
C) forming intermediate free phosphate (Pi). 
D) All of the above.

Question 13

2,3-bisphosphoglycerate is

Accepted Answer

A) an essential component of glycolysis for ATP production. 
B) converted to 3-phosphoglycerate with formation of ATP. 
C) essential for the efficient release of O² from hemoglobin. 
D) a product of the enzyme phosphofructokinase. 
A) an essential component of glycolysis for ATP production. 
B) converted to 3-phosphoglycerate with formation of ATP. 
C) essential for the efficient release of O² from hemoglobin. 
D) a product of the enzyme phosphofructokinase.

Question 14

The enzyme that catalyzes the conversion of pyruvate to lactate is ________.

Accepted Answer

A) lactate reductase 
B) pyruvate kinase 
C) lactoenolpyruvate 
D) lactate dehydrogenase 
A) lactate reductase 
B) pyruvate kinase 
C) lactoenolpyruvate 
D) lactate dehydrogenase

Question 15

Isozymes are different proteins from one species which catalyze different chemical reactions.

Accepted Answer

A) True 
 B)False

Question 16

Isozymes are enzymes

Accepted Answer

A) from one species that catalyze the same reaction. 
B) from different species that catalyze the same reaction. 
C) that have isomers as substrates. 
D) that have products that are isomers. 
A) from one species that catalyze the same reaction. 
B) from different species that catalyze the same reaction. 
C) that have isomers as substrates. 
D) that have products that are isomers.

Question 17

Glucose 6-phosphate allosterically inhibits

Accepted Answer

A) hexokinase I. 
B) glucokinase. 
C) hexokinase II. 
D) All of the above 
E) A and C only 
A) hexokinase I. 
B) glucokinase. 
C) hexokinase II. 
D) All of the above 
E) A and C only

Question 18

An increase in blood insulin concentration increases the rate of glucose uptake in adipose tissue and striated muscle cells.

Accepted Answer

A) True 
 B)False

Question 19

The genetic disorder galactosemia can cause ________ in infants.

Accepted Answer

A) inability to properly digest milk due to its galactose content 
B) jaundice 
C) damage to the nervous system 
D) liver damage 
E) All of the above 
A) inability to properly digest milk due to its galactose content 
B) jaundice 
C) damage to the nervous system 
D) liver damage 
E) All of the above

Question 20

Which must be satisfied to obtain net flux toward product in a metabolic pathway?

Accepted Answer

A) Each step in the pathway has an actual free energy change that is either negative or zero. 
B) The overall actual free energy change is negative. 
C) The net enthalpy is endothermic. 
D) A and B above. 
E) All of the above. 
A) Each step in the pathway has an actual free energy change that is either negative or zero. 
B) The overall actual free energy change is negative. 
C) The net enthalpy is endothermic. 
D) A and B above. 
E) All of the above.

Exam 11: Glycolysis

Which will be the main energy-producing degradation pathway for E.coli being grown on a medium where gluconate is the only carbon source?

Lactic acid produced by certain bacteria is used to curdle milk during cheese-making.

Phosphofructokinase I deficiency results in

How would the liver normally respond under condition of high glucose?

Insulin increases the capacity of a cell to transport glucose by

Arsenate

Under what situation might lactic acidosis occur?

Glucagon triggers the adenylate cyclase signally pathway.This activates protein kinase A which phosphorylates serine residues.

Seven of the ten reactions in the glycolytic pathway have free energy values close to zero.What does this tell us about those reactions?

Two molecules of ATP are consumed per glucose during the triose stage of glycolysis.

Mutases are described as

2,3-bisphosphoglycerate is

The enzyme that catalyzes the conversion of pyruvate to lactate is ________.

Isozymes are different proteins from one species which catalyze different chemical reactions.

Isozymes are enzymes

Glucose 6-phosphate allosterically inhibits

An increase in blood insulin concentration increases the rate of glucose uptake in adipose tissue and striated muscle cells.

The genetic disorder galactosemia can cause ________ in infants.

Which must be satisfied to obtain net flux toward product in a metabolic pathway?

Introduction to Biochemistry

Water

Amino Acids and the Primary Structures of Proteins

Proteins: Three-Dimensional Structure and Function

Properties of Enzymes

Mechanisms of Enzymes

Coenzymes and Vitamins

Carbohydrates

Lipids and Membranes

Introduction to Metabolism

Gluconeogenesis, the Pentose Phosphate Pathway, and Glycogen Metabolism

The Citric Acid Cycle

Electron Transport and Atp Synthesis

Photosynthesis

Lipid Metabolism

Amino Acid Metabolism

Nucleotide Metabolism

Nucleic Acids

DNA Replication, repair, and Recombination

Transcription and RNA Processing

Protein Synthesis

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