Exam 8: Family History and Pedigree Construction

Marjory tells a nurse that she has three aunts with cancer. The two on her father's side were diagnosed with breast and ovarian cancers at ages 42 and 36. Shealsohasone aunt on her mother's side who was diagnosed with breast cancer at age 70. Marjory asks if she should have genetic testing. What should the nurse tell her?

What is the significance of a pedigree symbol consisting of a square with a diagonal slash mark through it?

Which activity would a general registered nurse be expected to perform as part of genomic care?

What is the best way to ensure completeness and accuracy in constructing a pedigree?

What is the primary purpose of a pedigree?

What does a double horizontal line between a circle symbol and a square symbol as the only line directly connecting two individuals signify on a pedigree?

Which pair of relatives represents a first-degree relationship?

In the acronym "SCREEN" for formulating questions to ask that may indicate a heritable trait or health problem, what does the second "E" signify?

How are Punnett squares and pedigrees different?

A man with syndactyly, an autosomal-dominant condition, has one child who also has syndactyly. His unaffected wife states, "Because the risk for having a child withthis problem is 50% and our first child has the problem, the next child will not be affected." What is the best response to this statement?

What is the significance of a horizontal dashed line drawn between a male and a female?

Lois has Alzheimer's disease. She and her daughter Linda provided care for Lois's mother Leona when she had severe Alzheimer's disease. Now Linda, age 57, is showingsigns of impaired memory. Linda's daughter Lucy is pregnant with her first child and has contacted a genetic counselor to discuss Alzheimer's risk in her family. Who in this family is the proband?

Which observations in a pedigree indicate a probable autosomal-dominant (AD) trait transmission?

What is the risk for disease expression among the offspring of a woman who has an autosomal-recessive disorder when her partner is a carrier for the same disorder?

Why is a pedigree considered an "unstable" product?

When constructing a pedigree around a specific health problem, what is the minimal number of generations needed to accurately assess the presence or absence ofa genetic factor in disease development?

Which demographic information could have an important influence on susceptibility to disorders that have a strong genetic component?

Which issue is considered a "red flag" for the need for referral to a genetics professional?

Why is a legend necessary when constructing a pedigree that includes a health history?

How are twins indicated on a pedigree?