Question 1

In an Acute Phase Reaction (M.I., etc.), there is a(n):

Accepted Answer

A)  Decrease in albumin, increase in ?1-globulin, ?2-globulin, and ?3-globulin. 
B)  Intense band in ?1-globulin, increase in albumin. 
C)  Marked decrease in ?-globulin. 
D)  Marked increase in immunoglobulin A. 
E)  Increase in ?2-globulin. 
A)  Decrease in albumin, increase in ?1-globulin, ?2-globulin, and ?3-globulin. 
B)  Intense band in ?1-globulin, increase in albumin. 
C)  Marked decrease in ?-globulin. 
D)  Marked increase in immunoglobulin A. 
E)  Increase in ?2-globulin. A

Question 2

Which of the following conditions is associated with an elevated total protein?

Accepted Answer

A)  Cirrhosis 
B)  Glomerular disease 
C)  Starvation 
D)  Malignancy 
A)  Cirrhosis 
B)  Glomerular disease 
C)  Starvation 
D)  Malignancy D

Question 3

Which of the following conditions is usually associated with an acute inflammatory pattern?

Accepted Answer

A)  Myocardial infarction 
B)  Rheumatoid arthritis 
C)  Hepatitis 
D)  Surgery 
A)  Myocardial infarction 
B)  Rheumatoid arthritis 
C)  Hepatitis 
D)  Surgery A

Question 4

Hyperalbuminemia is caused by:

Accepted Answer

A)  Dehydration syndromes. 
B)  Liver disease. 
C)  Burns. 
D)  Gastroenteropathy. 
A)  Dehydration syndromes. 
B)  Liver disease. 
C)  Burns. 
D)  Gastroenteropathy.

Question 5

Which of the following serum proteins migrates with the beta globulins on cellulose acetate at pH 8.6?

Accepted Answer

A)  Ceruloplasmin 
B)  Hemopexin 
C)  Haptoglobin 
D)  Transthyretin 
A)  Ceruloplasmin 
B)  Hemopexin 
C)  Haptoglobin 
D)  Transthyretin

Question 6

A protein that is increased or normal in nephrotic syndrome is:

Accepted Answer

A)  ?1-antitrypsin. 
B)  ?2-macroglobulin. 
C)  Albumin. 
D)  Hemopexin. 
A)  ?1-antitrypsin. 
B)  ?2-macroglobulin. 
C)  Albumin. 
D)  Hemopexin.

Question 7

In agarose gel electrophoresis of human serum at pH 8.6, the slowest moving fraction is:

Accepted Answer

A)  ?-1 globulin. 
B)  ?-globulin. 
C)  ?-2 globulin. 
D)  Albumin. 
E)  ?-globulin. 
A)  ?-1 globulin. 
B)  ?-globulin. 
C)  ?-2 globulin. 
D)  Albumin. 
E)  ?-globulin.

Question 8

Which protein band comprises 2-5% of the relative protein?

Accepted Answer

A)  Albumin 
B)  ?1-globulin 
C)  ?2-globulin 
D)  ?-globulin 
A)  Albumin 
B)  ?1-globulin 
C)  ?2-globulin 
D)  ?-globulin

Question 9

The principal protein for transport of iron from the intestine to the liver, bone marrow, or spleen for storage is:

Accepted Answer

A)  Haptoglobin. 
B)  Transferrin. 
C)  Ceruloplasmin. 
D)  Alpha-fetoprotein. 
A)  Haptoglobin. 
B)  Transferrin. 
C)  Ceruloplasmin. 
D)  Alpha-fetoprotein.

Question 10

Ceruloplasmin is an ?2-globulin that contains:

Accepted Answer

A)  Copper. 
B)  Manganese. 
C)  Iron. 
D)  Zinc. 
A)  Copper. 
B)  Manganese. 
C)  Iron. 
D)  Zinc.

Question 11

Absence of a large decrease in the ?-1 globulin peak in a serum electrophoresis pattern suggests:

Accepted Answer

A)  Transferrin deficiency. 
B)  ?1- antitrypsin deficiency. 
C)  Nephrotic syndrome. 
D)  Chronic inflammation. 
A)  Transferrin deficiency. 
B)  ?1- antitrypsin deficiency. 
C)  Nephrotic syndrome. 
D)  Chronic inflammation.

Question 12

Which of the following proteins is part of the coagulation cascade?

Accepted Answer

A)  Complement 
B)  Fibrinogen 
C)  Transferrin 
D)  ?-microglobulin 
A)  Complement 
B)  Fibrinogen 
C)  Transferrin 
D)  ?-microglobulin

Question 13

Which condition is associated with fusion of the ?-? bridging?

Accepted Answer

A)  Cirrhosis 
B)  Acute pancreatitis 
C)  Myocardial infarction 
D)  Nephrotic syndrome 
A)  Cirrhosis 
B)  Acute pancreatitis 
C)  Myocardial infarction 
D)  Nephrotic syndrome

Question 14

Mary's total protein is 7.5 g/dL and her albumin is 4.2 g/dL. What is her A/G ratio?

Accepted Answer

A)  1.1 
B)  1.3 
C)  1.5 
D)  1.8 
A)  1.1 
B)  1.3 
C)  1.5 
D)  1.8

Question 15

A decrease in this protein will result in an emphysema-like condition.

Accepted Answer

A)  ?1-antitrypsin 
B)  ?2-macroglobulin 
C)  ?-lipoprotein 
D)  Hemopexin 
A)  ?1-antitrypsin 
B)  ?2-macroglobulin 
C)  ?-lipoprotein 
D)  Hemopexin

Question 16

High serum total protein but low albumin is usually seen in:

Accepted Answer

A)  Multiple myeloma. 
B)  Hepatic cirrhosis. 
C)  Glomerulonephritis. 
D)  Nephrotic syndrome. 
A)  Multiple myeloma. 
B)  Hepatic cirrhosis. 
C)  Glomerulonephritis. 
D)  Nephrotic syndrome.

Question 17

Myeloma (Bence Jones) protein is MOST often found electrophoretically in the area of:

Accepted Answer

A)  Albumin or ?1-globulins. 
B)  ?2-globulins. 
C)  ? or ? globulins. 
D)  ?1- or ?2-globulins. 
E)  ?-globulins. 
A)  Albumin or ?1-globulins. 
B)  ?2-globulins. 
C)  ? or ? globulins. 
D)  ?1- or ?2-globulins. 
E)  ?-globulins.

Question 18

Bill has a total protein of 7.5 g/dL and his protein electrophoresis reports a 12% ?-globulin. What is his ?-globulin level in g/dL?

Accepted Answer

A)  0.6 g/L 
B)  0.9 g/L 
C)  1.2 g/L 
D)  1.5 g/L 
A)  0.6 g/L 
B)  0.9 g/L 
C)  1.2 g/L 
D)  1.5 g/L

Question 19

The common ingredients of all biuret reagents are:

Accepted Answer

A)  Sodium potassium tartrate, copper sulfate, and sodium hydroxide. 
B)  Sodium tungstate and sulfuric acid. 
C)  Copper sulfate and NaOH. 
D)  Ammonium sulfate and sodium hydroxide. 
A)  Sodium potassium tartrate, copper sulfate, and sodium hydroxide. 
B)  Sodium tungstate and sulfuric acid. 
C)  Copper sulfate and NaOH. 
D)  Ammonium sulfate and sodium hydroxide.

Question 20

What is the clinical significance of testing for Transthyretin?

Accepted Answer

A)  High levels are associated with an acute phase reaction. 
B)  Levels are associated with glomerular injury in diabetic nephropathy. 
C)  Low levels indicate compromised nutritional status. 
D)  Low levels are associated with increased free cortisol. 
A)  High levels are associated with an acute phase reaction. 
B)  Levels are associated with glomerular injury in diabetic nephropathy. 
C)  Low levels indicate compromised nutritional status. 
D)  Low levels are associated with increased free cortisol.

Exam 9: Proteins

In an Acute Phase Reaction (M.I., etc.), there is a(n):

Which of the following conditions is associated with an elevated total protein?

Which of the following conditions is usually associated with an acute inflammatory pattern?

Hyperalbuminemia is caused by:

Which of the following serum proteins migrates with the beta globulins on cellulose acetate at pH 8.6?

A protein that is increased or normal in nephrotic syndrome is:

In agarose gel electrophoresis of human serum at pH 8.6, the slowest moving fraction is:

Which protein band comprises 2-5% of the relative protein?

The principal protein for transport of iron from the intestine to the liver, bone marrow, or spleen for storage is:

Ceruloplasmin is an ?2-globulin that contains:

Absence of a large decrease in the ?-1 globulin peak in a serum electrophoresis pattern suggests:

Which of the following proteins is part of the coagulation cascade?

Which condition is associated with fusion of the ?-? bridging?

Mary's total protein is 7.5 g/dL and her albumin is 4.2 g/dL. What is her A/G ratio?

A decrease in this protein will result in an emphysema-like condition.

High serum total protein but low albumin is usually seen in:

Myeloma (Bence Jones) protein is MOST often found electrophoretically in the area of:

Bill has a total protein of 7.5 g/dL and his protein electrophoresis reports a 12% ?-globulin. What is his ?-globulin level in g/dL?

The common ingredients of all biuret reagents are:

What is the clinical significance of testing for Transthyretin?

Laboratory Basics

Safety in the Clinical Chemistry Laboratory

Laboratory Statistics, Method Development and QC

Instrumentation, Laboratory Automation, and Informatics

Immunoassays

Molecular Diagnostics

Carbohydrates

Lipids

Enzymes

Nonprotein Nitrogen Questions

Body Water and Electrolyte Homeostasis

Blood Gases, PH, and Acid-Base Balance

Mineral and Bone Metabolism

The Endocrine System

Gastrointestinal Function

Pancreas

Cardiac Function

Liver

Iron, Porphyrins, and Hemoglobin

Therapeutic Drug Monitoring

Toxic Substances

Nutrition and Vitamins

Tumor Markers

Geriatrics

Pediatrics

Filters

Ceruloplasmin is an ?₂-globulin that contains: