Question 1

Which condition is not considered prothrombotic?

Accepted Answer

A) Graft versus host disease (GVH
D)  
B) Heparin-induced thrombocytopenia (HIT) 
C) Hemolytic uremic syndrome (HUS) 
D) Thrombotic thrombocytopenia purpura (TTP) 
A) Graft versus host disease (GVH
D)  
B) Heparin-induced thrombocytopenia (HIT) 
C) Hemolytic uremic syndrome (HUS) 
D) Thrombotic thrombocytopenia purpura (TTP) A

Question 2

Platelet transfusion is usually required to treat which of the following conditions?

Accepted Answer

A) Heparin-induced thrombocytopenia (HIT) 
B) Idiopathic thrombocytopenia purpura (ITP) 
C) Neonatal alloimmune thrombocytopenia (NAIT) 
D) Post-transfusion purpura (PTP) 
A) Heparin-induced thrombocytopenia (HIT) 
B) Idiopathic thrombocytopenia purpura (ITP) 
C) Neonatal alloimmune thrombocytopenia (NAIT) 
D) Post-transfusion purpura (PTP) C

Question 3

Which patients are at the highest risk for developing platelet refractoriness?

Accepted Answer

A) Anaesthetized surgical 
B) Bleeding trauma 
C) Chronically transfused oncology 
D) Multiparous obstetrical 
A) Anaesthetized surgical 
B) Bleeding trauma 
C) Chronically transfused oncology 
D) Multiparous obstetrical C

Question 4

Currently how many human platelet antigens (HPAs)have been identified?

Accepted Answer

A) 12 
B) 18 
C) 24 
D) 32 
A) 12 
B) 18 
C) 24 
D) 32

Question 5

Which is the most common causative agent of drug-induced immune thrombocytopenia today?

Accepted Answer

A) Amphotericin B 
B) Cephalexin 
C) Heparin 
D) Quinine 
A) Amphotericin B 
B) Cephalexin 
C) Heparin 
D) Quinine

Question 6

The antibodies most commonly implicated in immune platelet refractoriness are directed against which group of antigens?

Accepted Answer

A) ABO 
B) HLA 
C) HPA 
D) Rh 
A) ABO 
B) HLA 
C) HPA 
D) Rh

Question 7

What is an identical human leukocyte antigen (HLA)match called?

Accepted Answer

A) A 
B) BU 
C) C 
D) D 
A) A 
B) BU 
C) C 
D) D

Question 8

What is the first step to take when platelet refractoriness is suspected in a patient?

Accepted Answer

A) Confirm the response to the transfusion 
B) Obtain a complete and accurate history 
C) Screen the patient for HLA and/or HPA antibodies 
D) Transfuse ABO-identical platelets 
A) Confirm the response to the transfusion 
B) Obtain a complete and accurate history 
C) Screen the patient for HLA and/or HPA antibodies 
D) Transfuse ABO-identical platelets

Question 9

Accumulation of ultra-large multimers of von WilLeᵇrand factor causes which of the following conditions?

Accepted Answer

A) Disseminated intravascular coagulation (DI
C)  
B) Graft versus host disease (GVH
D)  
C) Heparin-induced thrombocytopenia (HIT) 
D) Thrombotic thrombocytopenia purpura (TTP) 
A) Disseminated intravascular coagulation (DI
C)  
B) Graft versus host disease (GVH
D)  
C) Heparin-induced thrombocytopenia (HIT) 
D) Thrombotic thrombocytopenia purpura (TTP)

Question 10

Platelets removed from circulation and stored by the spleen best describes which of the following terms?

Accepted Answer

A) Platelet alloimmunization 
B) Platelet consumption 
C) Platelet refractoriness 
D) Platelet sequestration 
A) Platelet alloimmunization 
B) Platelet consumption 
C) Platelet refractoriness 
D) Platelet sequestration

Question 11

Transfusion of which blood component is most often associated with post-transfusion purpura (PTP)?

Accepted Answer

A) Plasma 
B) Platelets 
C) Red blood cells 
D) White blood cells (granulocytes) 
A) Plasma 
B) Platelets 
C) Red blood cells 
D) White blood cells (granulocytes)

Question 12

An advantage of platelet crossmatching is

Accepted Answer

A) the immediate availability of compatible units 
B) the fact that it decreases the overall transfusion time 
C) that platelets have a shelf-life of 5 days 
D) that crossmatched platelets perform better than high-grade HLA-matched products 
A) the immediate availability of compatible units 
B) the fact that it decreases the overall transfusion time 
C) that platelets have a shelf-life of 5 days 
D) that crossmatched platelets perform better than high-grade HLA-matched products

Question 13

All of the following are factors that influence alloimmunization except

Accepted Answer

A) Antigen dose 
B) Consumption rate 
C) Immune status 
D) Prior exposure 
A) Antigen dose 
B) Consumption rate 
C) Immune status 
D) Prior exposure

Question 14

If the information necessary to calculate corrected count increment (CCI)or post-transfusion platelet recovery (PPR)is not available,a rough estimate of _________ increment per one unit of platelet concentrate transfused in an average adult patient can be used.

Accepted Answer

A) 500/µL 
B) 1,000/µL 
C) 2,000/µL 
D) 5,000/µL 
A) 500/µL 
B) 1,000/µL 
C) 2,000/µL 
D) 5,000/µL

Question 15

Which antibody is the most common cause of neonatal alloimmune thrombocytopenia?

Accepted Answer

A) Anti-HLA-DQ1 
B) Anti-HLA-Dq² 
C) Anti-HPA-1a 
D) Anti-HPA-1b 
A) Anti-HLA-DQ1 
B) Anti-HLA-Dq² 
C) Anti-HPA-1a 
D) Anti-HPA-1b

Question 16

Which of the following mechanisms results in immune-mediated platelet refractoriness?

Accepted Answer

A) Alloimmunization 
B) Consumption 
C) Sequestration 
D) Thrombosis 
A) Alloimmunization 
B) Consumption 
C) Sequestration 
D) Thrombosis

Question 17

What is the match called when one human leukocyte antigen (HLA)is mismatched?

Accepted Answer

A) A 
B) BU 
C) C 
D) D 
A) A 
B) BU 
C) C 
D) D

Question 18

What are the three most common human platelet antigen (HPA)antibodies implicated in platelet refractoriness?

Accepted Answer

A) Anti-HPA-1a,anti-HPA-2a,anti-HPA-5a 
B) Anti-HPA-1b,anti-HPA-2a,anti-HPA-5a 
C) Anti-HPA-1b,anti-HPA-2b,anti-HPA-5a 
D) Anti-HPA-1b,anti-HPA-2b,anti-HPA-5b 
A) Anti-HPA-1a,anti-HPA-2a,anti-HPA-5a 
B) Anti-HPA-1b,anti-HPA-2a,anti-HPA-5a 
C) Anti-HPA-1b,anti-HPA-2b,anti-HPA-5a 
D) Anti-HPA-1b,anti-HPA-2b,anti-HPA-5b

Question 19

Platelet refractoriness can be indicated by an immediate post-transfusion corrected count increment (CCI)of less than

Accepted Answer

A) 5,000 on at least one occasion 
B) 5,000 on at least two occasions 
C) 7,500 on at least one occasion 
D) 7,500 on at least two occasions 
A) 5,000 on at least one occasion 
B) 5,000 on at least two occasions 
C) 7,500 on at least one occasion 
D) 7,500 on at least two occasions

Question 20

Platelet counts should ideally be tested how long after a platelet transfusion?

Accepted Answer

A) 10-15 minutes and 12-14 hours 
B) 15-30 minutes and 18-20 hours 
C) 15-60 minutes and 20-24 hours 
D) 1 hour,24 hours,and 48 hours 
A) 10-15 minutes and 12-14 hours 
B) 15-30 minutes and 18-20 hours 
C) 15-60 minutes and 20-24 hours 
D) 1 hour,24 hours,and 48 hours

Exam 16: Platelet Refractory Patients

Which condition is not considered prothrombotic?

Platelet transfusion is usually required to treat which of the following conditions?

Which patients are at the highest risk for developing platelet refractoriness?

Currently how many human platelet antigens (HPAs)have been identified?

Which is the most common causative agent of drug-induced immune thrombocytopenia today?

The antibodies most commonly implicated in immune platelet refractoriness are directed against which group of antigens?

What is an identical human leukocyte antigen (HLA)match called?

What is the first step to take when platelet refractoriness is suspected in a patient?

Accumulation of ultra-large multimers of von WilLeᵇrand factor causes which of the following conditions?

Platelets removed from circulation and stored by the spleen best describes which of the following terms?

Transfusion of which blood component is most often associated with post-transfusion purpura (PTP)?

An advantage of platelet crossmatching is

All of the following are factors that influence alloimmunization except

If the information necessary to calculate corrected count increment (CCI)or post-transfusion platelet recovery (PPR)is not available,a rough estimate of _________ increment per one unit of platelet concentrate transfused in an average adult patient can be used.

Which antibody is the most common cause of neonatal alloimmune thrombocytopenia?

Which of the following mechanisms results in immune-mediated platelet refractoriness?

What is the match called when one human leukocyte antigen (HLA)is mismatched?

What are the three most common human platelet antigen (HPA)antibodies implicated in platelet refractoriness?

Platelet refractoriness can be indicated by an immediate post-transfusion corrected count increment (CCI)of less than

Platelet counts should ideally be tested how long after a platelet transfusion?

The Immune Process: the Origin and Interaction Between Antigens and Antibodies

Immunogenetics: the Origin of Antigens

Blood Bank Applications of Antigenantibody Reactions

Abo and Hh Blood Group Systems

Rh, Rhag, and Lw Blood Group Systems

Other Blood Group Systems

Pretransfusion and Compatibility Testing

Identification of Unexpected Antibodies

Donor Selection, Phlebotomy, and Required Testing

Blood Products: Preparation, Storage, and Shipment of Blood Components

Component Therapy and Massive Transfusion

Adverse Reactions to Transfusion

Transfusion-Transmitted Infections

Perinatal and Neonatal Transfusion Issues

Autoimmune and Drug-Induced Immune Hemolytic Anemias

Transfusion Support of Selected Patient Populations

Human Histocompatibility

Methods in Parentage Testing

Transfusion Safety and Regulatory Issues

Quality Assurance

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