Question 1

Which of the following are molecules produced and secreted by activated cells?

Accepted Answer

A) Cytokines 
B) Cytometries 
C) Cytosines 
D) Cytosols 
A) Cytokines 
B) Cytometries 
C) Cytosines 
D) Cytosols A

Question 2

The HLA class II genetic region is divided into which subregions?

Accepted Answer

A) DOA,DOB,DMA,DMB 
B) DP,DO/DM,DQ,DR 
C) HLA-A,HLA-B,HLA-C 
D) MIC-A,MIC-B 
A) DOA,DOB,DMA,DMB 
B) DP,DO/DM,DQ,DR 
C) HLA-A,HLA-B,HLA-C 
D) MIC-A,MIC-B B

Question 3

All of the following describe the adaptive immune system except

Accepted Answer

A) Also known as the natural immune system 
B) Consists of antigen presenting cells 
C) Displays an anamnestic response 
D) Is involved in allograft rejection 
A) Also known as the natural immune system 
B) Consists of antigen presenting cells 
C) Displays an anamnestic response 
D) Is involved in allograft rejection A

Question 4

When matching a recipient and potential donor for kidney transplant,all of the following antigens should be identified except

Accepted Answer

A) HLA-A 
B) HLA-B 
C) HLA-DQ 
D) HLA-DR 
A) HLA-A 
B) HLA-B 
C) HLA-DQ 
D) HLA-DR

Question 5

All of the following are true about HLA class I molecules except

Accepted Answer

A) Are expressed only on antigen presenting cells 
B) Includes a 45 kDa α glycoprotein heavy chain 
C) Includes a 12 kDa β-2 microglobulin light chain 
D) Has a peptide-binding cleft that reacts with short peptides 
A) Are expressed only on antigen presenting cells 
B) Includes a 45 kDa α glycoprotein heavy chain 
C) Includes a 12 kDa β-2 microglobulin light chain 
D) Has a peptide-binding cleft that reacts with short peptides

Question 6

If all possible alleles have the same nucleotide sequence in the exons coding for the peptide-binding domains,the string is reported as the possible allele with the lowest number followed by a capital

Accepted Answer

A) A 
B) D 
C) G 
D) P 
A) A 
B) D 
C) G 
D) P

Question 7

Which type of transplant is frequently used to treat genetic and acquired dysfunction of the bone marrow?

Accepted Answer

A) Bone 
B) B lymphocyte cell 
C) Hematopoeitic progenitor cell 
D) Liver 
A) Bone 
B) B lymphocyte cell 
C) Hematopoeitic progenitor cell 
D) Liver

Question 8

Which chromosome carries the genes for the HLA system?

Accepted Answer

A) 1 
B) 3 
C) 6 
D) 9 
A) 1 
B) 3 
C) 6 
D) 9

Question 9

How many DRB genes exist in the human population?

Accepted Answer

A) 1 
B) 5 
C) 9 
D) 10 
A) 1 
B) 5 
C) 9 
D) 10

Question 10

Which of the following methods is typically used to crossmatch a recipient's serum with donor lymphocytes?

Accepted Answer

A) Flow cytometry 
B) Sequence-specific primer typing 
C) Signal transduction 
D) Solid phase assay 
A) Flow cytometry 
B) Sequence-specific primer typing 
C) Signal transduction 
D) Solid phase assay

Question 11

What is the best description of a CREG?

Accepted Answer

A) Group of alleles on the same chromosome that are often inherited together 
B) Group of antigens that all react with an antibody directed against a common epitope 
C) Group of antigens resulting from alleles that are independently segregated 
D) Group of HLA antibodies that react with a particular epitope common to multiple bacteria 
A) Group of alleles on the same chromosome that are often inherited together 
B) Group of antigens that all react with an antibody directed against a common epitope 
C) Group of antigens resulting from alleles that are independently segregated 
D) Group of HLA antibodies that react with a particular epitope common to multiple bacteria

Question 12

Which antigen would not be considered a Class I antigen?

Accepted Answer

A) HLA-A 
B) HLA-B 
C) HLA-C 
D) HLA-D 
A) HLA-A 
B) HLA-B 
C) HLA-C 
D) HLA-D

Question 13

Which HLA class of molecules is used in solid phase assays?

Accepted Answer

A) Class I only 
B) Class II only 
C) Class III only 
D) Class I or II 
A) Class I only 
B) Class II only 
C) Class III only 
D) Class I or II

Question 14

All of the following are typical monitoring tests performed after a kidney transplant except

Accepted Answer

A) C4D staining and histological analysis 
B) Serum creatinine level 
C) Serum complement level 
D) Urinary output 
A) C4D staining and histological analysis 
B) Serum creatinine level 
C) Serum complement level 
D) Urinary output

Question 15

The SSO (sequence-specific oligonucleotide)probe hybridization method

Accepted Answer

A) begins with amplification of the target DNA 
B) determines the nucleotide sequence of the entire exon 
C) employs primer pairs that are specific for unique sequences within an exon 
D) uses two rounds of polymerase chain reaction (PCR) 
A) begins with amplification of the target DNA 
B) determines the nucleotide sequence of the entire exon 
C) employs primer pairs that are specific for unique sequences within an exon 
D) uses two rounds of polymerase chain reaction (PCR)

Question 16

When matching a recipient and donor for hematopoietic progenitor cell (HPC)transplant,how many alleles should be identified in the donor and recipient?

Accepted Answer

A) 8 
B) 10 
C) 12 
D) 16 
A) 8 
B) 10 
C) 12 
D) 16

Question 17

A crossmatch using autologous lymphocytes can indicate if which of the following is present?

Accepted Answer

A) Alloantibodies 
B) Autoantibodies 
C) IgG 
D) IgM 
A) Alloantibodies 
B) Autoantibodies 
C) IgG 
D) IgM

Question 18

Which of the following is the correct term used for "multiple genes expressed in an individual that produce similar products"?

Accepted Answer

A) Polymorphic 
B) Polygenic 
C) Polymerase 
D) Pseudogene 
A) Polymorphic 
B) Polygenic 
C) Polymerase 
D) Pseudogene

Question 19

When discussing the 2010 naming convention,all of the following statements are true except

Accepted Answer

A) The first set of numbers is called the allele family. 
B) The second set of numbers is assigned in order of the allele's discovery. 
C) The third set of numbers differentiates alleles that have different DNA sequences in the noncoding areas of the gene. 
D) The fourth set of numbers refers to differences in the untranslated end pieces of DNA. 
A) The first set of numbers is called the allele family. 
B) The second set of numbers is assigned in order of the allele's discovery. 
C) The third set of numbers differentiates alleles that have different DNA sequences in the noncoding areas of the gene. 
D) The fourth set of numbers refers to differences in the untranslated end pieces of DNA.

Question 20

In humans the major histocompatibility complex (MHC)is also called the _____ system.

Accepted Answer

A) DRA 
B) HAL 
C) HLA 
D) MIC 
A) DRA 
B) HAL 
C) HLA 
D) MIC

Exam 18: Human Histocompatibility

Which of the following are molecules produced and secreted by activated cells?

The HLA class II genetic region is divided into which subregions?

All of the following describe the adaptive immune system except

When matching a recipient and potential donor for kidney transplant,all of the following antigens should be identified except

All of the following are true about HLA class I molecules except

If all possible alleles have the same nucleotide sequence in the exons coding for the peptide-binding domains,the string is reported as the possible allele with the lowest number followed by a capital

Which type of transplant is frequently used to treat genetic and acquired dysfunction of the bone marrow?

Which chromosome carries the genes for the HLA system?

How many DRB genes exist in the human population?

Which of the following methods is typically used to crossmatch a recipient's serum with donor lymphocytes?

What is the best description of a CREG?

Which antigen would not be considered a Class I antigen?

Which HLA class of molecules is used in solid phase assays?

All of the following are typical monitoring tests performed after a kidney transplant except

The SSO (sequence-specific oligonucleotide)probe hybridization method

When matching a recipient and donor for hematopoietic progenitor cell (HPC)transplant,how many alleles should be identified in the donor and recipient?

A crossmatch using autologous lymphocytes can indicate if which of the following is present?

Which of the following is the correct term used for "multiple genes expressed in an individual that produce similar products"?

When discussing the 2010 naming convention,all of the following statements are true except

In humans the major histocompatibility complex (MHC)is also called the _____ system.

The Immune Process: the Origin and Interaction Between Antigens and Antibodies

Immunogenetics: the Origin of Antigens

Blood Bank Applications of Antigenantibody Reactions

Abo and Hh Blood Group Systems

Rh, Rhag, and Lw Blood Group Systems

Other Blood Group Systems

Pretransfusion and Compatibility Testing

Identification of Unexpected Antibodies

Donor Selection, Phlebotomy, and Required Testing

Blood Products: Preparation, Storage, and Shipment of Blood Components

Component Therapy and Massive Transfusion

Adverse Reactions to Transfusion

Transfusion-Transmitted Infections

Perinatal and Neonatal Transfusion Issues

Autoimmune and Drug-Induced Immune Hemolytic Anemias

Platelet Refractory Patients

Transfusion Support of Selected Patient Populations

Methods in Parentage Testing

Transfusion Safety and Regulatory Issues

Quality Assurance

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