Question 1

Chronic administration of meperidine should be avoided for which reason?

Accepted Answer

A)  greater risk of drug dependence than with other opioids 
B)  auto-induction of drug metabolism enzymes 
C)  development of pharmacodynamic drug tolerance 
D)  increased suicidal ideations 
E)  accumulation of a toxic metabolite 
A)  greater risk of drug dependence than with other opioids 
B)  auto-induction of drug metabolism enzymes 
C)  development of pharmacodynamic drug tolerance 
D)  increased suicidal ideations 
E)  accumulation of a toxic metabolite E

Question 2

Which adverse effect may result from administration of buprenorphine to a man who is illicitly taking oxycodone?

Accepted Answer

A)  hypertensive crisis 
B)  cardiac arrest 
C)  opioid withdrawal reaction 
D)  malignant hyperthermia 
E)  apnea due to depression of respiratory centers 
A)  hypertensive crisis 
B)  cardiac arrest 
C)  opioid withdrawal reaction 
D)  malignant hyperthermia 
E)  apnea due to depression of respiratory centers C

Question 3

The analgesic effect of tramadol is partly attributed to which action?

Accepted Answer

A)  inhibition of prostaglandin synthesis 
B)  activation of descending inhibitory pathways 
C)  activation of α₂-adrenoceptors in the spinal cord 
D)  depletion of substance P from afferent neurons 
E)  partial agonist activity at kappa opioid receptors 
A)  inhibition of prostaglandin synthesis 
B)  activation of descending inhibitory pathways 
C)  activation of α₂-adrenoceptors in the spinal cord 
D)  depletion of substance P from afferent neurons 
E)  partial agonist activity at kappa opioid receptors B

Question 4

A woman experiences hallucinations and paranoid ideations after receiving an opioid analgesic in the emergency department.This adverse effect most likely results from activation of which receptors?

Accepted Answer

A)  mu and delta 
B)  delta and kappa 
C)  mu and kappa 
D)  kappa and sigma 
E)  mu and sigma 
A)  mu and delta 
B)  delta and kappa 
C)  mu and kappa 
D)  kappa and sigma 
E)  mu and sigma

Exam 23: Opioid Analgesics and Antagonists

Chronic administration of meperidine should be avoided for which reason?

Which adverse effect may result from administration of buprenorphine to a man who is illicitly taking oxycodone?

The analgesic effect of tramadol is partly attributed to which action?

A woman experiences hallucinations and paranoid ideations after receiving an opioid analgesic in the emergency department.This adverse effect most likely results from activation of which receptors?

Introduction to Pharmacology

Pharmacokinetics

Pharmacodynamics

Drug Development and Safety

Introduction to Autonomic and Neuromuscular Pharmacology

Acetylcholine Receptor Agonists

Acetylcholine Receptor Antagonists

Adrenoceptor Agonists

Adrenoceptor Antagonists

Antihypertensive Drugs

Antianginal Drugs

Drugs for Heart Failure

Diuretics

Antiarrhythmic Drugs

Drugs for Hyperlipidemia

Anticoagulant, Antiplatelet, and Fibrinolytic Drugs

Hematopoietic Drugs

Introduction to Central Nervous System Pharmacology

Sedative-Hypnotic and Anxiolytic Drugs

Antiepileptic Drugs

Local and General Anesthetics

Psychotherapeutic Drugs

Drugs for Neurodegenerative Diseases

Drugs of Abuse

Autacoid Drugs

Drugs for Respiratory Tract Disorders

Drugs for Gastrointestinal Tract Disorders

Drugs for Headache Disorders

Drugs for Pain, Inflammation, and Arthritic Disorders

Hypothalamic and Pituitary Drugs

Thyroid Drugs

Adrenal Steroids and Related Drugs

Drugs Affecting Fertility and Reproduction

Drugs for Diabetes Mellitus

Drugs Affecting Calcium and Bone

Principles of Antimicrobial Chemotherapy

Inhibitors of Bacterial Cell Wall Synthesis

Inhibitors of Bacterial Protein Synthesis

Quinolones, Antifolate Drugs, and Other Antimicrobial Agents

Antimycobacterial Drugs

Antifungal Drugs

Antiviral Drugs

Antiparasitic Drugs

Antineoplastic and Immunomodulating Drugs

Filters