Question 1

Blockade of which receptors is responsible for the antiemetic effect of aprepitant?

Accepted Answer

A)  histamine H₁ 
B)  serotonin 5-HT₃ 
C)  muscarinic acetylcholine M₁ 
D)  dopamine D₂ 
E)  neurokinin NK₁ 
A)  histamine H₁ 
B)  serotonin 5-HT₃ 
C)  muscarinic acetylcholine M₁ 
D)  dopamine D₂ 
E)  neurokinin NK₁ E

Question 2

By which mechanism does lubiprostone relieve some cases of severe idiopathic constipation?

Accepted Answer

A)  blockade of serotonin 5-HT₃ receptors 
B)  activation of serotonin 5-HT₄ receptors 
C)  inhibition of fluid reabsorption in the colon 
D)  stimulation of the parasympathetic nervous system 
E)  activation of chloride channels 
A)  blockade of serotonin 5-HT₃ receptors 
B)  activation of serotonin 5-HT₄ receptors 
C)  inhibition of fluid reabsorption in the colon 
D)  stimulation of the parasympathetic nervous system 
E)  activation of chloride channels E

Question 3

Which event is involved in the inhibition of gastric acid secretion by pantoprazole?

Accepted Answer

A)  blockade of histamine H₂ receptors 
B)  competitive inhibition of H⁺, K⁺-ATPase 
C)  formation of an active drug metabolite 
D)  metabolism by cytochrome P450 2C19 
E)  stimulation of prostaglandin synthesis 
A)  blockade of histamine H₂ receptors 
B)  competitive inhibition of H⁺, K⁺-ATPase 
C)  formation of an active drug metabolite 
D)  metabolism by cytochrome P450 2C19 
E)  stimulation of prostaglandin synthesis C

Question 4

A pregnant woman complains of being constipated most days despite eating a well-balanced diet and drinking plenty of water.Which agent would provide the most physiological approach to treating her problem?

Accepted Answer

A)  bisacodyl 
B)  sodium phosphate 
C)  senna 
D)  psyllium 
E)  castor oil 
A)  bisacodyl 
B)  sodium phosphate 
C)  senna 
D)  psyllium 
E)  castor oil

Exam 28: Drugs for Gastrointestinal Tract Disorders

Blockade of which receptors is responsible for the antiemetic effect of aprepitant?

By which mechanism does lubiprostone relieve some cases of severe idiopathic constipation?

Which event is involved in the inhibition of gastric acid secretion by pantoprazole?

A pregnant woman complains of being constipated most days despite eating a well-balanced diet and drinking plenty of water.Which agent would provide the most physiological approach to treating her problem?

Introduction to Pharmacology

Pharmacokinetics

Pharmacodynamics

Drug Development and Safety

Introduction to Autonomic and Neuromuscular Pharmacology

Acetylcholine Receptor Agonists

Acetylcholine Receptor Antagonists

Adrenoceptor Agonists

Adrenoceptor Antagonists

Antihypertensive Drugs

Antianginal Drugs

Drugs for Heart Failure

Diuretics

Antiarrhythmic Drugs

Drugs for Hyperlipidemia

Anticoagulant, Antiplatelet, and Fibrinolytic Drugs

Hematopoietic Drugs

Introduction to Central Nervous System Pharmacology

Sedative-Hypnotic and Anxiolytic Drugs

Antiepileptic Drugs

Local and General Anesthetics

Psychotherapeutic Drugs

Opioid Analgesics and Antagonists

Drugs for Neurodegenerative Diseases

Drugs of Abuse

Autacoid Drugs

Drugs for Respiratory Tract Disorders

Drugs for Headache Disorders

Drugs for Pain, Inflammation, and Arthritic Disorders

Hypothalamic and Pituitary Drugs

Thyroid Drugs

Adrenal Steroids and Related Drugs

Drugs Affecting Fertility and Reproduction

Drugs for Diabetes Mellitus

Drugs Affecting Calcium and Bone

Principles of Antimicrobial Chemotherapy

Inhibitors of Bacterial Cell Wall Synthesis

Inhibitors of Bacterial Protein Synthesis

Quinolones, Antifolate Drugs, and Other Antimicrobial Agents

Antimycobacterial Drugs

Antifungal Drugs

Antiviral Drugs

Antiparasitic Drugs

Antineoplastic and Immunomodulating Drugs

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