Exam 39: Alzheimers Disease in Women

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Data from three randomized, placebo-controlled trials of unopposed estrogen therapy on episodic verbal memory in women younger than age 65 indicates that estrogen alone either enhances or has no effect on verbal memory in younger women during short-term follow-up.

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(True/False)

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Question 1

Correct Answer:

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True

What is the usual disease duration in AD?

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(Essay)

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Question 2

Correct Answer:

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While disease duration in AD may range from 3 to 20 years, the usual duration is 7 to 10 years with slow progression.

List three of the brain changes which, along with the presence of dementia, are required for a diagnosis of AD.

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Question 3

Correct Answer:

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Responses should include any three of the following:
●Atrophy
●Neuronal loss
●Presence of extracellular plaques containing beta amyloid peptides
●Intracellular neurofibrillary tangles
●Granulovacuolar cytoplasmic changes in the neocortical association areas, hippocampus, and other brain regions

Which of the following is a behavioral manifestation of moderate AD?

(Multiple Choice)

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Question 4

High intake of _____ can lower the risk of cardiovascular disease and potentially lower the risk of AD through vascular mechanisms.

(Multiple Choice)

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Question 5

Which statement about estrogen is correct?

(Multiple Choice)

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Question 6

Research data indicates that lower lifetime endogenous estrogen exposure increases the risk of dementia in the Down Syndrome population.

(True/False)

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Question 7

All studies of AD have shown a significantly higher incidence in women compared with men.

(True/False)

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Question 8

Moderate alcohol consumption in human beings is related to _____.

(Multiple Choice)

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Question 9

What two key genes are involved in the peripheral synthesis of estrogens?

(Multiple Choice)

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Question 10

Which of the four genes clinically available for genetic testing for AD is a susceptibility gene that is neither sufficient nor necessary to cause AD?

(Multiple Choice)

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Question 11

Which antioxidant blocks the creation of nitrosamines through the reduction of nitrites, and may also affect catecholamine synthesis?

(Multiple Choice)

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Question 12

How do cholinesterase inhibitors enhance cholinergic function, and why is this beneficial to AD patients?

(Essay)

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Question 13

Structural neuroimaging is used to verify an AD diagnosis.

(True/False)

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Question 14

AD currently affects 1 in 8 men and women over age 65.

(True/False)

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Question 15

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Exam 39: Alzheimers Disease in Women

Data from three randomized, placebo-controlled trials of unopposed estrogen therapy on episodic verbal memory in women younger than age 65 indicates that estrogen alone either enhances or has no effect on verbal memory in younger women during short-term follow-up.

What is the usual disease duration in AD?

List three of the brain changes which, along with the presence of dementia, are required for a diagnosis of AD.

Which of the following is a behavioral manifestation of moderate AD?

High intake of _____ can lower the risk of cardiovascular disease and potentially lower the risk of AD through vascular mechanisms.

Which statement about estrogen is correct?

Research data indicates that lower lifetime endogenous estrogen exposure increases the risk of dementia in the Down Syndrome population.

All studies of AD have shown a significantly higher incidence in women compared with men.

Moderate alcohol consumption in human beings is related to _____.

What two key genes are involved in the peripheral synthesis of estrogens?

Which of the four genes clinically available for genetic testing for AD is a susceptibility gene that is neither sufficient nor necessary to cause AD?

Which antioxidant blocks the creation of nitrosamines through the reduction of nitrites, and may also affect catecholamine synthesis?

How do cholinesterase inhibitors enhance cholinergic function, and why is this beneficial to AD patients?

Structural neuroimaging is used to verify an AD diagnosis.

AD currently affects 1 in 8 men and women over age 65.

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