Exam 24: The Innate and Adaptive Immune Systems

Indicate whether each of the following cell-surface proteins is expressed mainly by B cells (B), dendritic cells (D), or T cells (T). Your answer would be a four-letter string composed of letters B, D, and T only, e.g. DBBB. ( ) Co-stimulatory protein B7, which is recognized by CD28 ( ) Invariant CD3 complex ( ) Inhibitory CTLA4 protein ( ) CD40 receptor, which recognizes the co-stimulatory protein CD40 ligand on a helper T cell

The transcription regulator AIRE (autoimmune regulator) plays a key role in developing immunological self-tolerance by promoting the production of various cellular proteins that are mainly expressed outside the thymus. Which of the following cells have the highest level of AIRE?

Indicate true (T) and false (F) statements below regarding the proteins of our adaptive immune system. Your answer would be a four-letter string composed of letters T and F only, e.g. TTFT. ( ) Both B cell receptors and T cell receptors have domains with an immunoglobulin fold, which consists of a ?-sandwich and an intrachain disulfide bond. ( ) MHC proteins are the most polymorphic among human proteins. ( ) MHC proteins and CD4 and CD8 co-receptors are all members of the Ig superfamily. ( ) Both B cell receptors and T cell receptors are stably associated with invariant transmembrane protein chains that are required for activating intracellular signaling pathways.

T cell receptors that do not interact at all with self-peptide-MHC complexes during T cell development in the thymus normally undergo …

Indicate whether each of the following statements is true (T) or false (F) regarding all the cell-surface immunoglobulin molecules produced by a single, mature, naïve B cell. ( ) They all have the same heavy chain. ( ) They all have the same light chain. ( ) They all have the same antigen-binding site.

Which of the following groups of proteins are pattern recognition receptors?

Which of the following are recognized by pattern recognition receptors as pathogen-associated molecular patterns?