Question 1

What is the function of aspartate transcarbamoylase?

Accepted Answer

The enzyme catalyzes the first

Question 2

What protein is administered after heart attacks to increase survival odds, and what is the biochemistry involved?

Accepted Answer

Tissue-type plasminogen activator, or TP

Question 3

Do allosteric enzymes follow traditional Michaelis-Menten kinetics? Draw a graph of rate relative to substrate concentration for ATCase and compare it to a Michaelis-Menten enzyme.

Accepted Answer

No, ATCase displays different kinetics.

Question 4

Why is covalent modification advantageous when compared to proteolytic activation?

Accepted Answer

Covalent modificatio

Question 5

Allosteric proteins

Accepted Answer

A)  usually display hyperbolic Michaelis-Menten kinetics. 
B)  often display cooperativity. 
C)  always consist of several identical subunits. 
D)  usually display hyperbolic Michaelis-Menten kinetics and often display cooperativity. 
E)  All of the answers are correct. 
A)  usually display hyperbolic Michaelis-Menten kinetics. 
B)  often display cooperativity. 
C)  always consist of several identical subunits. 
D)  usually display hyperbolic Michaelis-Menten kinetics and often display cooperativity. 
E)  All of the answers are correct.

Question 6

Give several examples of enzymes and proteins that are activated by proteolytic activation.

Accepted Answer

Examples include digestive enz

Question 7

Many allosteric enzymes have two types of subunits, termed

Accepted Answer

A)  catalytic and regulatory. 
B)  regulatory and allosteric. 
C)  allosteric and regulatory. 
D)  R-state and T-state. 
E)  None of the answers is correct. 
A)  catalytic and regulatory. 
B)  regulatory and allosteric. 
C)  allosteric and regulatory. 
D)  R-state and T-state. 
E)  None of the answers is correct.

Question 8

How is chymotrypsinogen activated?

Accepted Answer

A)  cleavage between an Arg and Ile by chymotrypsin 
B)  cAMP binding, followed by cleavage by elastase 
C)  cleavage between an Arg and Ile by trypsin 
D)  All of the answers are correct. 
E)  None of the answers is correct. 
A)  cleavage between an Arg and Ile by chymotrypsin 
B)  cAMP binding, followed by cleavage by elastase 
C)  cleavage between an Arg and Ile by trypsin 
D)  All of the answers are correct. 
E)  None of the answers is correct.

Question 9

Removal of protein phosphates is catalyzed by protein _____.

Accepted Answer

A)  phosphate hydrolase 
B)  phosphatase 
C)  kinase 
D)  dephosphorylase 
E)  None of the answers is correct. 
A)  phosphate hydrolase 
B)  phosphatase 
C)  kinase 
D)  dephosphorylase 
E)  None of the answers is correct.

Question 10

Histones are acetylated at specific ________________ residues.

Accepted Answer

The answer of Histones are acetylated at specific ________________ residues....

Question 11

How can cleavage of a single peptide bond activate a zymogen?

Accepted Answer

The switching on of enzymatic

Question 12

Why are certain forms of lactate dehydrogenase used as heart attack indicators?

Accepted Answer

LDH is a tetramer, made of M and H isozy

Question 13

The ____________ pathway is activated by exposure of anionic surfaces on ruptured endothelial cells.

Accepted Answer

The answer of The ____________ pathway is activated by exposure...

Question 14

Which type of enzymes specifically catalyzes protein phosphorylation?

Accepted Answer

A)  protein ATPase 
B)  protein transferases 
C)  protein phosphatases 
D)  protein kinases 
E)  None of the answers is correct. 
A)  protein ATPase 
B)  protein transferases 
C)  protein phosphatases 
D)  protein kinases 
E)  None of the answers is correct.

Question 15

Multifunctional kinases phosphorylate proteins by recognizing related sequences called

Accepted Answer

A)  cAMP binding sequences. 
B)  calmodulin binding sequences. 
C)  pseudosubstrate sequences. 
D)  consensus sequences. 
E)  palindromes. 
A)  cAMP binding sequences. 
B)  calmodulin binding sequences. 
C)  pseudosubstrate sequences. 
D)  consensus sequences. 
E)  palindromes.

Question 16

Examples of covalent modification include

Accepted Answer

A)  phosphorylation and dephosphorylation. 
B)  acetylation. 
C)  ubiquitination. 
D)  All of the answers are correct. 
E)  phosphorylation, dephosphorylation, and acetylation. 
A)  phosphorylation and dephosphorylation. 
B)  acetylation. 
C)  ubiquitination. 
D)  All of the answers are correct. 
E)  phosphorylation, dephosphorylation, and acetylation.

Question 17

Describe how the PKA kinase cascade is activated.

Accepted Answer

The process is often initiated by hormon

Question 18

Individuals in a royal family suffered from hemophilia and often died early from bleeding. What is the cause of this disease? How is it treated?

Accepted Answer

The disease in the royal family was caus

Question 19

The effects of substrates on allosteric enzymes are referred to as ___________________ effects.

Accepted Answer

The answer of The effects of substrates on allosteric enzymes...

Question 20

The less active conformational form of an allosteric enzyme is called the _____.

Accepted Answer

A)  T-state 
B)  M-state 
C)  R-state 
D)  I-state 
E)  L-state 
A)  T-state 
B)  M-state 
C)  R-state 
D)  I-state 
E)  L-state

Exam 10: Regulatory Strategies

What is the function of aspartate transcarbamoylase?

What protein is administered after heart attacks to increase survival odds, and what is the biochemistry involved?

Do allosteric enzymes follow traditional Michaelis-Menten kinetics? Draw a graph of rate relative to substrate concentration for ATCase and compare it to a Michaelis-Menten enzyme.

Why is covalent modification advantageous when compared to proteolytic activation?

Allosteric proteins

Give several examples of enzymes and proteins that are activated by proteolytic activation.

Many allosteric enzymes have two types of subunits, termed

How is chymotrypsinogen activated?

Removal of protein phosphates is catalyzed by protein _____.

Histones are acetylated at specific ________________ residues.

How can cleavage of a single peptide bond activate a zymogen?

Why are certain forms of lactate dehydrogenase used as heart attack indicators?

The ____________ pathway is activated by exposure of anionic surfaces on ruptured endothelial cells.

Which type of enzymes specifically catalyzes protein phosphorylation?

Multifunctional kinases phosphorylate proteins by recognizing related sequences called

Examples of covalent modification include

Describe how the PKA kinase cascade is activated.

Individuals in a royal family suffered from hemophilia and often died early from bleeding. What is the cause of this disease? How is it treated?

The effects of substrates on allosteric enzymes are referred to as ___________________ effects.

The less active conformational form of an allosteric enzyme is called the _____.

Biochemistry: an Evolving Science

Protein Composition and Structure

Exploring Proteins and Proteomes

DNA, RNA, and the Flow of Genetic Information

Exploring Genes and Genomes

Exploring Evolution and Bioinformatics

Hemoglobin: a Portrait of a Protein in Action

Enzymes: Basic Concepts and Kinetics

Oxidative Phosphorylation

Catalytic Strategies

Carbohydrates

Lipids and Cell Membranes

Membrane Channels and Pumps

Signal-Transduction Pathways

Metabolism: Basic Concepts and Design

Glycolysis and Gluconeogenesis

The Citric Acid Cycle

The Light Reactions of Photosynthesis

The Calvin Cycle and the Pentose Phosphate Pathway

Glycogen Metabolism

Fatty Acid Metabolism

Protein Turnover and Amino Acid Catabolism

The Biosynthesis of Amino Acids

Nucleotide Biosynthesis

Biosynthesis of Membrane Lipids and Steroids

The Integration of Metabolism

DNA Replication, Repair, and Recombination

Rna Synthesis and Processing

Protein Synthesis

The Control of Gene Expression in Prokaryotes

The Control of Gene Expression in Eukaryotes

Sensory Systems

The Immune System

Molecular Motors

Drug Development

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