Exam 34: The Immune System

Explain why the amino terminal immunoglobulin domains of the L and H chains have hypervariable sequences.

The immunoglobulin with the highest serum concentration is _______________.

When the heavy chain is switched to make secreted antibodies, how is the specificity of antigen binding maintained?

How is the immune system diversity similar to evolutionary processes?

What mechanism is useful for protection against intracellular pathogens such as viruses?

To what family does interleukin-2 belong?

An immunogen is

MHC class I and II proteins bind and present _______________ to T cells.

The differentiation of a cell to make a different type of immunoglobulin is called

What membrane glycoprotein is found in GI cells of developing fetuses?

A(n) __________________ disease is one wherein the body attacks itself and produces self-antigens.

___________________ sequences are recognized by proteins RAG-1 and RAG-2 and facilitate cleavage and religation of DNA segments.

_______________ are molecules that induce differentiation, cell growth, and in certain cells, secretion of antibodies.

What is the major class of antibodies found in saliva and tears?

Cyclosporin blocks the action of the enzyme _______________.

Are unrelated humans likely to have similar class II genes?

What modification(s) of tyrosines in the ITAM region of membrane-linked IgG molecules is (are) critical to immune response formation?

What is the result of the complement cascade?

What are the steps in cytotoxic T-cell activation?

What are the proteases released by cytotoxic T cells that initiate the apoptotic cascade in virus-infected cells?