Exam 16: Disruption of Healthy Tissue by the Adaptive Immune Response

Autoantibody specificities are affected by HLA class II polymorphisms.In the case of systemic lupus erythematosus,indicate which of the following associations between HLA-class II and autoantigens have been observed in these patients.

Thyroid-stimulating hormone is made in the _____ and induces the release of thyroid hormones after proteolytic processing of _____.

Characterize two properties of endocrine glands that render them susceptible to autoimmune attack.

Anders Anderson,was seen by his pediatrician at 24 months old after a recent bout of diarrhea and vomiting.He had lost his appetite and complained that his stomach hurt.Anders was in the 5% centile for weight,had slender limbs,wasted buttocks,and a protuberant abdomen.Jejunal biopsy revealed abnormal surface epithelium,and villous atrophy with hyperplasia of the crypts.Which of the following would be a likely clinical finding in this patient?