Exam 16: Disruption of Healthy Tissue by the Adaptive Immune Response

Which of the following is an example of a type IV autoimmune response? (Select all that apply.)

With the exception of ______,these autoimmune diseases are more prevalent in women than in men.

_____ autoantibodies enhance receptor function.

Seventeen-year-old Lisa Montague practiced piano for 3-4 hours each day while preparing for music college auditions.Some of her pieces required sustained arm-muscle activity and she began to find them hard to play,even though she had previously played them easily.When she also started to have difficulty swallowing and chewing,she told her mother,who took her to the emergency room,where the physician noticed drooping eyelids and limitation of ocular motility.An electromyogram detected impaired nerve-to-muscle transmission.Administration of pyridostigmine rapidly improved Lisa's symptoms.Which of the following blood-test results would be most consistent with her condition?

In the context of autoimmunity: (A)define molecular mimicry; and (B)provide an example.

A.What mechanism of self-tolerance is broken in the autoimmune syndrome APECED? B.What is the underlying genetic defect in APECED? Explain why it leads to a reduction in self-tolerance.

Deficiency in the production of AIRE results in _____.(Select all that apply.)

All of the following are true regarding thyroglobulin except _____.

Chronic diseases in which the immune response is targeted toward autologous entities of one's body are known as _____.

A.Which patients affected by Goodpasture's syndrome also succumb to pulmonary hemorrhage? B.Explain the reason for this complication.

_____ is the term used to describe how pathogen antigens resemble host antigens and can sometimes trigger autoimmune disease.

Describe two different ways in which infection with bacteria or viruses compromises T-cell tolerance,leading to the production of effector T cells specific for self antigens.

If autoantibodies of the IgG or IgM isotype were produced with specificity for components found on the surface of erythrocytes,which of the following would occur? (Select all that apply.)

Explain the mechanism that gives rise to a broadening B-cell response during the course of systemic lupus erythematosus.

A recent therapy developed for the treatment of rheumatoid arthritis includes the use of _____ monoclonal antibodies that suppress the autoimmune response.(Select all that apply.)

Explain why splenectomy is sometimes carried out in patients with persistent type II autoimmune diseases that affect leukocytes.

A(n)_____ binds to the antigen-binding site of another antibody.

Which of the following is an example of a type III autoimmune response? (Select all that apply.)

Individuals who have two defective alleles of the AIRE gene _____.