Question 1

Match the following description with the term:
-Nucleus undergoes fragmentation

Accepted Answer

A)  Karyolysis 
B)  Pyknosis 
C)  Karyorrhexis

Question 2

Match the type of chronic inflammation with the associated disease:
-Prolonged exposure to potentially toxic agents

Accepted Answer

A)  Silicosis 
B)  Rheumatoid arthritis 
C)  Treponema pallidum

Question 3

Which of the following types of atrophy is involved in marasmus?

Accepted Answer

A)  Decreased workload 
B)  Loss of innervation 
C)  Diminished blood supply 
D)  Inadequate nutrition (protein-calorie) 
E)  Loss of endrocrine stimulation f) Aging (senile atrophy)
G) Pressure

Question 4

Which of the following is inhibitory to the Fas (extrinsic) apoptosis pathway?

Accepted Answer

A)  FasL 
B)  FADD 
C)  FLIP 
D)  Pro Caspase-8 
E)  Active Caspase-8

Question 5

Match the following description with the term:
-Basophilia of the chromatin may fade

Accepted Answer

A)  Karyolysis 
B)  Pyknosis 
C)  Karyorrhexis

Question 6

Match the mediator or acute inflammation with the source and action: Source Vascular Leakage Chemotaxis & Other
-Plasma substrate +-, pain

Accepted Answer

A)  Histamine, serotonin 
B)  Leukotrienes C4, D4, E5 
C)  Nitric oxide 
D)  Chemokines 
E)  IL-1, TNF
F) Bradykinin
G) PAF
H) C3a
I) C5a
J) Leukotriene B4
K) O2 metabolites
L) Prostaglandins

Question 7

Match the type of apoptosis with the involved item:
-Apoptosis After Growth Factor Deprivation

Accepted Answer

A)  p53 
B)  Granzyme B 
C)  FasL 
D)  Bcl

Question 8

Expression of the CD-31 marker (PECAM-1) does which of the following?

Accepted Answer

A)  Prevents neutrophils from binding to macrophages 
B)  Allows neutrophils to bind to macrophages 
C)  Prevents neutrophils from being phagocytized 
D)  Allows neutrophils to be phagocytized 
E)  Is only expressed on the surface of cancer cells

Question 9

Which of the following caspases is an executioner and not an initiator of apoptosis?

Accepted Answer

A)  CASP2 
B)  CASP8 
C)  CASP9 
D)  CASP10 
E)  CASP3, CASP6, CASP7

Question 10

Which of the following is associated with cell death and NOT specifically with reversible cell injury?

Accepted Answer

A)  Membrane blebs 
B)  Clumping of chromatin 
C)  Swelling of ER 
D)  Swelling of mitochondria 
E)  Myelin ﬁgures

Question 11

Acute and Chronic Inflammation
-Vascular changes associated with acute inflammation include_____ (from histamine and NO) and vascular permeability.

Accepted Answer

A)  Vasoconstriction; Decreased 
B)  Vasoconstriction; Increased 
C)  Vasodilation; Decreased 
D)  Vasodilation; Increased

Question 12

Match the cellular response normally seen in cells with the stimuli (description):
-Decreased nutrients, stimulation

Accepted Answer

A)  Hyperplasia/Hypertrophy 
B)  Atrophy 
C)  Metaplasia 
D)  Injury/Necrosis/Apoptosis 
E)  Calcifications/Intracellular accumulations

Question 13

Match the type of apoptosis with the involved item:
-Apoptosis Induced by Tumor Necrosis Factor Family of Receptors

Accepted Answer

A)  p55 
B)  Granzyme B 
C)  FasL 
D)  Bcl

Question 14

Match the mediator or acute inflammation with the source and action: Source Vascular Leakage Chemotaxis & Other
-Leukocytes -+ , leukocyte adhesion

Accepted Answer

A)  Histamine, serotonin 
B)  Leukotrienes C4, D4, E9 
C)  Nitric oxide 
D)  Chemokines 
E)  IL-1, TNF
F) Bradykinin
G) PAF
H) C3a
I) C5a
J) Leukotriene B4
K) O2 metabolites
L) Prostaglandins

Question 15

Like tissue necrosis, cell apoptosis causes inﬂammation.

Accepted Answer

A) True 
 B)False

Question 16

A patient presents with an infection of the hand and red streaks along the arm and into the axilla, with painful nodules in the axilla. This is due to a secondary inflammation of the , which in ﬂow due to the infection.

Accepted Answer

A)  Blood; Increased 
B)  Blood; Decreased 
C)  Lymph; Increased 
D)  Lymph; Decreased

Question 17

Which cellular organelle contains acid hydrolases (e.g. cathepsins) and other enzymes to degrade endocytosed proteins from the extracellular environment and the cell surface as well as some cellular components during atrophy?

Accepted Answer

A)  Smooth ER 
B)  Rough ER 
C)  Golgi 
D)  Mitochondria 
E)  Lysosomes

Question 18

Which of the following describes metaplasia?

Accepted Answer

A)  Increase in the number of cells (mitosis) in an organ or tissue 
B)  Decrease in the number of cells (mitosis) in an organ or tissue 
C)  Increase in individual cell size in an organ or tissue 
D)  Decrease in individual cell size in an organ or tissue 
E)  Reversible change in which one adult cell is replaced by another adult cell type

Question 19

In the image to the right, A is normal myocardium and B is myocardium with coagulation necrosis. Which of the following can be discerned in B, suggesting necrosis?

Accepted Answer

A)  Eosinophilia 
B)  Myeline ﬁgures 
C)  Blebbing 
D)  Cell swelling 
E)  Apoptosis

Question 20

Match the endothelial molecule (leukocyte adhesion molecule) with its major role:
-Leukocyte migration through endothelium

Accepted Answer

A)  ICAM-1 
B)  P-selectin 
C)  E-selectin 
D)  VCAM-1 
E)  GlyCam-1
F) CD31 (PECAM)

Exam 1: Pathology

Match the following description with the term: -Nucleus undergoes fragmentation

Match the type of chronic inflammation with the associated disease: -Prolonged exposure to potentially toxic agents

Which of the following types of atrophy is involved in marasmus?

Which of the following is inhibitory to the Fas (extrinsic) apoptosis pathway?

Match the following description with the term: -Basophilia of the chromatin may fade

Match the mediator or acute inflammation with the source and action: Source Vascular Leakage Chemotaxis & Other -Plasma substrate +-, pain

Match the type of apoptosis with the involved item: -Apoptosis After Growth Factor Deprivation

Expression of the CD-31 marker (PECAM-1) does which of the following?

Which of the following caspases is an executioner and not an initiator of apoptosis?

Which of the following is associated with cell death and NOT specifically with reversible cell injury?

Acute and Chronic Inflammation -Vascular changes associated with acute inflammation include_____ (from histamine and NO) and vascular permeability.

Match the cellular response normally seen in cells with the stimuli (description) : -Decreased nutrients, stimulation

Match the type of apoptosis with the involved item: -Apoptosis Induced by Tumor Necrosis Factor Family of Receptors

Match the mediator or acute inflammation with the source and action: Source Vascular Leakage Chemotaxis & Other -Leukocytes -+ , leukocyte adhesion

Like tissue necrosis, cell apoptosis causes inﬂammation.

A patient presents with an infection of the hand and red streaks along the arm and into the axilla, with painful nodules in the axilla. This is due to a secondary inflammation of the , which in ﬂow due to the infection.

Which cellular organelle contains acid hydrolases (e.g. cathepsins) and other enzymes to degrade endocytosed proteins from the extracellular environment and the cell surface as well as some cellular components during atrophy?

Which of the following describes metaplasia?

In the image to the right, A is normal myocardium and B is myocardium with coagulation necrosis. Which of the following can be discerned in B, suggesting necrosis?

Match the endothelial molecule (leukocyte adhesion molecule) with its major role: -Leukocyte migration through endothelium