A65-Year-Old Man Comes to His Physician Because of Progressively Worsening

A65-year-old man comes to his physician because of progressively worsening shortness of breath for the past 2 months. He does not experience shortness of breath at rest. He also occasionally has a dry cough. He has not had fever, chills, or night sweats. The patient has smoked a pack of cigarettes daily for 40 years. His temperature is 37°C (98.6°F) , pulse is 86/min, respirations are 22/min, and blood pressure is 133/85 mm Hg. Lung auscultation reveals a prolonged expiratory phase and end-expiratory wheezing. Spirometry shows an FEV1:FVC ratio of 62%, an FEV1 of 60% of predicted, and a total lung capacity of 125% of predicted. Which of the following cells most likely played a major role in the pathogenesis of this patient's lung condition?

A) B lymphocytes
B) CD4⁺ T lymphocytes
C) Eosinophils
D) Mast cells
E) Neutrophils

Correct Answer:

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