A 50-Year-Old Man Is Going to Have a Colonoscopy Done

A 50-year-old man is going to have a colonoscopy done as part of a normal checkup for colorectal cancer. He doesn't have any constipation, obvious blood in his stool, abdominal pain, altered stool consistency, or unexpected weight loss. He has no known family members who have had colon cancer. The surgery is straightforward, however a little mucosal lesion (less than 1 cm) is discovered in the patient's sigmoid colon. The image below shows the histology of the biopsy-found lesion. The pathogenesis of this patient's lesion most likely began with a mutation involving which of the following genes?

A) APC
B) DCC
C) K-RAS
D) MSH2
E) p53

Correct Answer:

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