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Passage Mitochondria Are Double Membrane-Bound Cellular Organelles That House Several Connected

Question 68

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Passage
Mitochondria are double membrane-bound cellular organelles that house several connected metabolic reactions.  The citric acid cycle takes place inside the mitochondrial matrix and produces two reduced electron carriers, NADH and FADH2.  These two carriers then pass their electrons to ubiquinone (UQ) , which is reduced to ubiquinol (UQH2) .  UQH2 passes its electrons to oxidized cytochrome C (cyt-Cox) , regenerating UQ and forming reduced cytochrome C (cyt-Cred) .  Finally, cyt-Cred transfers electrons to oxygen, regenerating cyt-Cox and forming water.  Each reaction is facilitated by one of four protein complexes that are collectively known as the electron transport chain (ETC) .Researchers isolated mitochondria and treated them with a novel ETC inhibitor, "drug X."  After an overnight incubation, they measured levels of several ETC-reduced electron carriers in the presence of drug X relative to untreated mitochondria.  Their results are shown in Figure 1.
Passage Mitochondria are double membrane-bound cellular organelles that house several connected metabolic reactions.  The citric acid cycle takes place inside the mitochondrial matrix and produces two reduced electron carriers, NADH and FADH<sub>2</sub>.  These two carriers then pass their electrons to ubiquinone (UQ) , which is reduced to ubiquinol (UQH<sub>2</sub>) .  UQH<sub>2</sub> passes its electrons to oxidized cytochrome C (cyt-C<sub>ox</sub>) , regenerating UQ and forming reduced cytochrome C (cyt-C<sub>red</sub>) .  Finally, cyt-C<sub>red</sub> transfers electrons to oxygen, regenerating cyt-C<sub>ox</sub> and forming water.  Each reaction is facilitated by one of four protein complexes that are collectively known as the electron transport chain (ETC) .Researchers isolated mitochondria and treated them with a novel ETC inhibitor, drug X.   After an overnight incubation, they measured levels of several ETC-reduced electron carriers in the presence of drug X relative to untreated mitochondria.  Their results are shown in Figure 1. <strong>Figure 1</strong>  Relative levels of reduced electron carriers in the presence and absence of drug XNext, the researchers exposed mitochondria to FCCP, a chemical that can transport protons across membranes.  They observed that in the presence of FCCP, the citric acid cycle was fully active, and all reduced cofactors were present at the same levels as in untreated mitochondria.  However, the rate of ATP synthesis was significantly reduced.  ATP synthesis was immediately restored when FCCP was washed away. -Which of the following molecules is a precursor to the citric acid cycle? A) B) C) D) Figure 1  Relative levels of reduced electron carriers in the presence and absence of drug XNext, the researchers exposed mitochondria to FCCP, a chemical that can transport protons across membranes.  They observed that in the presence of FCCP, the citric acid cycle was fully active, and all reduced cofactors were present at the same levels as in untreated mitochondria.  However, the rate of ATP synthesis was significantly reduced.  ATP synthesis was immediately restored when FCCP was washed away.
-Which of the following molecules is a precursor to the citric acid cycle?


A) Passage Mitochondria are double membrane-bound cellular organelles that house several connected metabolic reactions.  The citric acid cycle takes place inside the mitochondrial matrix and produces two reduced electron carriers, NADH and FADH<sub>2</sub>.  These two carriers then pass their electrons to ubiquinone (UQ) , which is reduced to ubiquinol (UQH<sub>2</sub>) .  UQH<sub>2</sub> passes its electrons to oxidized cytochrome C (cyt-C<sub>ox</sub>) , regenerating UQ and forming reduced cytochrome C (cyt-C<sub>red</sub>) .  Finally, cyt-C<sub>red</sub> transfers electrons to oxygen, regenerating cyt-C<sub>ox</sub> and forming water.  Each reaction is facilitated by one of four protein complexes that are collectively known as the electron transport chain (ETC) .Researchers isolated mitochondria and treated them with a novel ETC inhibitor, drug X.   After an overnight incubation, they measured levels of several ETC-reduced electron carriers in the presence of drug X relative to untreated mitochondria.  Their results are shown in Figure 1. <strong>Figure 1</strong>  Relative levels of reduced electron carriers in the presence and absence of drug XNext, the researchers exposed mitochondria to FCCP, a chemical that can transport protons across membranes.  They observed that in the presence of FCCP, the citric acid cycle was fully active, and all reduced cofactors were present at the same levels as in untreated mitochondria.  However, the rate of ATP synthesis was significantly reduced.  ATP synthesis was immediately restored when FCCP was washed away. -Which of the following molecules is a precursor to the citric acid cycle? A) B) C) D)
B) Passage Mitochondria are double membrane-bound cellular organelles that house several connected metabolic reactions.  The citric acid cycle takes place inside the mitochondrial matrix and produces two reduced electron carriers, NADH and FADH<sub>2</sub>.  These two carriers then pass their electrons to ubiquinone (UQ) , which is reduced to ubiquinol (UQH<sub>2</sub>) .  UQH<sub>2</sub> passes its electrons to oxidized cytochrome C (cyt-C<sub>ox</sub>) , regenerating UQ and forming reduced cytochrome C (cyt-C<sub>red</sub>) .  Finally, cyt-C<sub>red</sub> transfers electrons to oxygen, regenerating cyt-C<sub>ox</sub> and forming water.  Each reaction is facilitated by one of four protein complexes that are collectively known as the electron transport chain (ETC) .Researchers isolated mitochondria and treated them with a novel ETC inhibitor, drug X.   After an overnight incubation, they measured levels of several ETC-reduced electron carriers in the presence of drug X relative to untreated mitochondria.  Their results are shown in Figure 1. <strong>Figure 1</strong>  Relative levels of reduced electron carriers in the presence and absence of drug XNext, the researchers exposed mitochondria to FCCP, a chemical that can transport protons across membranes.  They observed that in the presence of FCCP, the citric acid cycle was fully active, and all reduced cofactors were present at the same levels as in untreated mitochondria.  However, the rate of ATP synthesis was significantly reduced.  ATP synthesis was immediately restored when FCCP was washed away. -Which of the following molecules is a precursor to the citric acid cycle? A) B) C) D)
C) Passage Mitochondria are double membrane-bound cellular organelles that house several connected metabolic reactions.  The citric acid cycle takes place inside the mitochondrial matrix and produces two reduced electron carriers, NADH and FADH<sub>2</sub>.  These two carriers then pass their electrons to ubiquinone (UQ) , which is reduced to ubiquinol (UQH<sub>2</sub>) .  UQH<sub>2</sub> passes its electrons to oxidized cytochrome C (cyt-C<sub>ox</sub>) , regenerating UQ and forming reduced cytochrome C (cyt-C<sub>red</sub>) .  Finally, cyt-C<sub>red</sub> transfers electrons to oxygen, regenerating cyt-C<sub>ox</sub> and forming water.  Each reaction is facilitated by one of four protein complexes that are collectively known as the electron transport chain (ETC) .Researchers isolated mitochondria and treated them with a novel ETC inhibitor, drug X.   After an overnight incubation, they measured levels of several ETC-reduced electron carriers in the presence of drug X relative to untreated mitochondria.  Their results are shown in Figure 1. <strong>Figure 1</strong>  Relative levels of reduced electron carriers in the presence and absence of drug XNext, the researchers exposed mitochondria to FCCP, a chemical that can transport protons across membranes.  They observed that in the presence of FCCP, the citric acid cycle was fully active, and all reduced cofactors were present at the same levels as in untreated mitochondria.  However, the rate of ATP synthesis was significantly reduced.  ATP synthesis was immediately restored when FCCP was washed away. -Which of the following molecules is a precursor to the citric acid cycle? A) B) C) D)
D) Passage Mitochondria are double membrane-bound cellular organelles that house several connected metabolic reactions.  The citric acid cycle takes place inside the mitochondrial matrix and produces two reduced electron carriers, NADH and FADH<sub>2</sub>.  These two carriers then pass their electrons to ubiquinone (UQ) , which is reduced to ubiquinol (UQH<sub>2</sub>) .  UQH<sub>2</sub> passes its electrons to oxidized cytochrome C (cyt-C<sub>ox</sub>) , regenerating UQ and forming reduced cytochrome C (cyt-C<sub>red</sub>) .  Finally, cyt-C<sub>red</sub> transfers electrons to oxygen, regenerating cyt-C<sub>ox</sub> and forming water.  Each reaction is facilitated by one of four protein complexes that are collectively known as the electron transport chain (ETC) .Researchers isolated mitochondria and treated them with a novel ETC inhibitor, drug X.   After an overnight incubation, they measured levels of several ETC-reduced electron carriers in the presence of drug X relative to untreated mitochondria.  Their results are shown in Figure 1. <strong>Figure 1</strong>  Relative levels of reduced electron carriers in the presence and absence of drug XNext, the researchers exposed mitochondria to FCCP, a chemical that can transport protons across membranes.  They observed that in the presence of FCCP, the citric acid cycle was fully active, and all reduced cofactors were present at the same levels as in untreated mitochondria.  However, the rate of ATP synthesis was significantly reduced.  ATP synthesis was immediately restored when FCCP was washed away. -Which of the following molecules is a precursor to the citric acid cycle? A) B) C) D)

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