A 46-Year-Old Man Is Diagnosed with Resistant Hypertension

A 46-year-old man is diagnosed with resistant hypertension.  He had a comprehensive workup for secondary hypertension, which was unrevealing.  The patient has tried multiple antihypertensive medications without significant effect.  Past medical history is otherwise unremarkable.  He agrees to enroll in a trial of a new long-acting medication that causes selective direct relaxation of the smooth muscle of arterioles but does not affect the veins.  Which of the following adverse effects is most likely to be caused by the drug during the clinical trial?

A) Angioedema
B) Bradycardia
C) Cold extremities
D) Decreased cardiac output
E) Persistent cough
F) Sodium and fluid retention
G) Transient hypertension

Correct Answer:

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