Physiologists Conduct a Series of Experiments on Hypophysectomized Animals to Investigate

Physiologists conduct a series of experiments on hypophysectomized animals to investigate the effects of cortisol on vascular reactivity.  Their initial tests show that administration of cortisol alone does not elicit a vascular response.  Next, the researchers measure vascular reactivity to an infusion of norepinephrine both with and without pretreatment with cortisol.  The results of their experiments are shown in the graph below. Which of the following pharmacologic principles best describes the effect of cortisol in this experiment?

A) Additive effect
B) Alteration in metabolism
C) Permissiveness
D) Synergistic effect
E) Tachyphylaxis

Correct Answer:

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