A 32-Year-Old Man Comes to the Clinic Due to Several

A 32-year-old man comes to the clinic due to several months of fatigue and weight loss.  The patient has no significant medical history.  He drinks 1 or 2 alcoholic beverages daily and has used intravenous recreational drugs in the past.  He is sexually active with his girlfriend.  The patient has a maternal aunt with hypothyroidism, but his family history is otherwise unremarkable.  Temperature is 36.7 C (98 F) , blood pressure is 110/70 mm Hg, pulse is 65/min, and respirations are 18/min.  Physical examination is normal.  A liver biopsy is obtained, and light microscopy reveals large hepatocytes filled with finely granular, homogeneous, pale pink cytoplasm.  Which of the following is the most likely diagnosis?

A) Alcohol-induced steatohepatitis
B) Hemochromatosis
C) Hepatitis B infection
D) Hepatitis C infection
E) Nonalcoholic steatohepatitis

Correct Answer:

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