A 55-Year-Old Caucasian Male Is Found on Colonoscopy to Have

A 55-year-old Caucasian male is found on colonoscopy to have a solitary mass in his sigmoid colon.  Biopsy is consistent with colon cancer, and surgery is scheduled.  Which of the following features would carry the worst prognosis in this patient?

A) Presence of clinical symptoms
B) Tumor penetration into the muscularis propria
C) Poor differentiation of tumor cells
D) High degree of tumor cell aneuploidy
E) High number of mitotic figures

Correct Answer:

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