An 80-Year-Old Woman Is Evaluated for Blisters That Have Developed

An 80-year-old woman is evaluated for blisters that have developed on both feet over the past week.  The patient lives in a nursing home due to dementia but has no other chronic medical conditions and takes no medication.  Vital signs are within normal limits.  There are no oral lesions.  Examination findings are shown in the exhibit. 
Which of the following is most likely involved in the pathogenesis of this patient's condition?

A) Deposition of IgA-containing immune complexes within dermal papillae
B) Deposition of IgG and complement at the dermal-epidermal junction
C) Deposition of IgG within the epidermal layer at the intercellular level
D) Disrupted assembly of keratin into monofilaments
E) Increased vascular permeability due to gaps between endothelial cells

Correct Answer:

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