A 15-Year-Old Girl Is Evaluated Due to Persistent Fever, Fatigue

A 15-year-old girl is evaluated due to persistent fever, fatigue, and sore throat.  Physical examination reveals splenomegaly and symmetric posterior cervical lymphadenopathy.  Peripheral blood smear results are shown in the image below: The atypical cells seen here are most likely an activated form of which of the following?

A) CD4⁺ Helper lymphocytes
B) CD8⁺ Cytotoxic lymphocytes
C) CD14⁺ Monocytes
D) CD21⁺ Lymphocytes
E) CD27⁺ Plasma cells

Correct Answer:

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