A 24-Year-Old, Previously Healthy Woman Is Evaluated for Skin Rash

A 24-year-old, previously healthy woman is evaluated for skin rash, joint pains, and renal failure.  She is found to have decreased C3 and C4 levels and a normal factor B level.  Which of the following most likely triggered the complement system activation in this patient?

A) Antigens binding to IgA
B) Autoactivation of C3 component
C) C1 components binding to C1 inhibitor
D) C9-lipid membrane complex formation
E) IgG-antigen complex formation

Correct Answer:

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