The Patient's Anaphylactic Reaction Is Determined to Be Mediated by Antigen-Specific

The patient's anaphylactic reaction is determined to be mediated by antigen-specific IgE antibodies attached to high-affinity receptors on the surface of mast cells and basophils.  Which of the following mechanisms is most likely to trigger vasoactive substance release by these cells?

A) Antibody-receptor covalent binding
B) Antibody-receptor dissociation
C) Receptor aggregation
D) Receptor detachment from the cell surface
E) Receptor internalization

Correct Answer:

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