A Pharmaceutical Researcher Performs Preclinical Testing on a Novel Chemotherapeutic

A pharmaceutical researcher performs preclinical testing on a novel chemotherapeutic drug.  When rat embryos are exposed to this drug during an early stage of organogenesis, they develop severe skeletal malformations.  Further genetic analysis reveals that the drug causes mutations in numerous homeobox genes containing highly conserved 180 base pair DNA sequences.  The genes affected by this drug most likely code for which of the following proteins?

A) Cell surface receptors
B) Cytoplasmic enzymes
C) DNA replication enzymes
D) Structural proteins
E) Transcription regulators
F) Transport proteins

Correct Answer:

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