A 13-Year-Old Boy with Growth Retardation, Microcephaly, Sun-Sensitive Skin Rash

A 13-year-old boy with growth retardation, microcephaly, sun-sensitive skin rash, and recurrent infections is being evaluated for a possible inherited genetic defect.  The patient is the second-born child of a first cousin marriage.  His parents and siblings are healthy, but 2 of his maternal cousins have similar signs and symptoms.  Genetic analysis of the patient reveals a defect in the BLM gene that codes for DNA helicase.  Which of the following is the most likely site of action of this enzyme in the DNA replication fork shown below?

A) A
B) B
C) C
D) D
E) E
F) F

Correct Answer:

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