A 45-Year-Old Man Comes to the Office for a Routine

A 45-year-old man comes to the office for a routine visit.  The patient has a first-degree relative with Alzheimer dementia and is concerned about his chances of developing the disease.  He has read in the newspaper that decreased consumption of yellow and orange fruits and vegetables has been associated with Alzheimer disease and would like to know how likely he is to develop the disease.  A medical literature review uncovers a recent cohort study that evaluated the association between blood carotene concentration and Alzheimer disease.  The development of the disease was evaluated in a 20-year follow-up study of 200 middle-aged subjects who have a first-degree relative with Alzheimer disease.  The results are as follows: Assuming the patient has low carotene levels, what is his 20-year risk of developing Alzheimer disease?

A) 0.19
B) 0.23
C) 0.27
D) 0.30
E) 0.40

Correct Answer:

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