Question 1

__________________ is the critical functional group of lipoamide responsible for carrying acetyl groups and maintaining the free energy of CoA.

Accepted Answer

The answer of __________________ is the critical functional group of...

Question 2

Which of the following conditions will activate PDH kinase, which catalyzes the phorphorylation and inactivation of E1 in the PDH complex?

Accepted Answer

A)  elevated concentrations of NADH and ATP 
B)  elevated concentrations of NAD+ and ADP 
C)  Ca2+ 
D)  insulin 
E)  elevated concentrations of acetyl CoA 
A)  elevated concentrations of NADH and ATP 
B)  elevated concentrations of NAD+ and ADP 
C)  Ca2+ 
D)  insulin 
E)  elevated concentrations of acetyl CoA

Question 3

E2 of the PDH complex contains a lipoyl group that is covalently attached to a __________________ residue of the enzyme.

Accepted Answer

Question 4

What are the three enzyme subunits in the PDH complex and the reactions they catalyze?

Accepted Answer

E1 is the PDH component and catalyzes th

Question 5

PDH is inactivated when it the enzyme is __________________.

Accepted Answer

The answer of PDH is inactivated when it the enzyme...

Question 6

Choose the correct answer from the list below. Not all of the answers will be used.
-The activated carrier of acyl groups is ________________.

Accepted Answer

A) scurvy 
B) phosphorylation 
C) beriberi 
D) mitochondria 
E) acetyl CoA
F)E3
G)thiamine pyrophosphate
H)lipoamide
I)pyruvate dehydrogenase
J)coenzyme A
K)E1
L)glyoxylate cycle 
A) scurvy 
B) phosphorylation 
C) beriberi 
D) mitochondria 
E) acetyl CoA
F)E3
G)thiamine pyrophosphate
H)lipoamide
I)pyruvate dehydrogenase
J)coenzyme A
K)E1
L)glyoxylate cycle

Question 7

What are the two advantages that are derived from the coordinated actions of the three enzymes in the PDH complex?

Accepted Answer

The proximity of one enzyme to

Question 8

__________________ inserts the lipoamide arm of the SH domain deep into the channel in E1.

Accepted Answer

Question 9

E1 of the PDH complex requires the coenzyme __________________ for proper activity.

Accepted Answer

thiamine p

Question 10

Decarboxylation, oxidation, and __________________ are the three steps critical to preserve the free energy derived from decarboxylation of the PDH complex.

Accepted Answer

The answer of Decarboxylation, oxidation, and __________________ are the three...

Question 11

Choose the correct answer from the list below. Not all of the answers will be used.
-________________ provides a flexible linker between active siteswithin the pyruvate dehydrogenase (PDH) complex.

Accepted Answer

A) scurvy 
B) phosphorylation 
C) beriberi 
D) mitochondria 
E) acetyl CoA
F)E3
G)thiamine pyrophosphate
H)lipoamide
I)pyruvate dehydrogenase
J)coenzyme A
K)E1
L)glyoxylate cycle 
A) scurvy 
B) phosphorylation 
C) beriberi 
D) mitochondria 
E) acetyl CoA
F)E3
G)thiamine pyrophosphate
H)lipoamide
I)pyruvate dehydrogenase
J)coenzyme A
K)E1
L)glyoxylate cycle

Question 12

__________________ is the PDH subunit responsible for the regeneration of the oxidized form of lipoamide.

Accepted Answer

Dihydrolip

Question 13

Choose the correct answer from the list below. Not all of the answers will be used.
-The coenzyme ________________ is the prosthetic group in the decarboxylation of pyruvate.

Accepted Answer

A) scurvy 
B) phosphorylation 
C) beriberi 
D) mitochondria 
E) acetyl CoA
F)E3
G)thiamine pyrophosphate
H)lipoamide
I)pyruvate dehydrogenase
J)coenzyme A
K)E1
L)glyoxylate cycle 
A) scurvy 
B) phosphorylation 
C) beriberi 
D) mitochondria 
E) acetyl CoA
F)E3
G)thiamine pyrophosphate
H)lipoamide
I)pyruvate dehydrogenase
J)coenzyme A
K)E1
L)glyoxylate cycle

Question 14

Which enzyme(s) is/are responsible for the following reaction? Pyruvate + CoA + NAD+ → Acetyl CoA + NADH + H+ + CO2

Accepted Answer

A)  acetyl CoA synthetase 
B)  pyruvate decarboxylase 
C)  pyruvate dehydrogenase complex 
D)  A and B 
E)  A, B, and C 
A)  acetyl CoA synthetase 
B)  pyruvate decarboxylase 
C)  pyruvate dehydrogenase complex 
D)  A and B 
E)  A, B, and C

Question 15

The high-energy charge which results in increasing concentration of NADH __________________ the activity of PDH.

Accepted Answer

The answer of The high-energy charge which results in increasing...

Question 16

Choose the correct answer from the list below. Not all of the answers will be used.
-________________ is a large, multi-subunit enzyme complex that links glycolysis and the citric acid cycle under aerobic conditions.

Accepted Answer

A) scurvy 
B) phosphorylation 
C) beriberi 
D) mitochondria 
E) acetyl CoA
F)E3
G)thiamine pyrophosphate
H)lipoamide
I)pyruvate dehydrogenase
J)coenzyme A
K)E1
L)glyoxylate cycle 
A) scurvy 
B) phosphorylation 
C) beriberi 
D) mitochondria 
E) acetyl CoA
F)E3
G)thiamine pyrophosphate
H)lipoamide
I)pyruvate dehydrogenase
J)coenzyme A
K)E1
L)glyoxylate cycle

Question 17

Review the fates of pyruvate and the cellular conditions that dictate these fates.

Accepted Answer

Under anaerobic conditions, pyruvate und

Question 18

The citric acid cycle is also known as the:

Accepted Answer

A)  Krebs cycle. 
B)  Cori cycle. 
C)  tricarboxylic acid cycle. 
D)  A and B. 
E)  A, B, and C. 
A)  Krebs cycle. 
B)  Cori cycle. 
C)  tricarboxylic acid cycle. 
D)  A and B. 
E)  A, B, and C.

Question 19

Choose the correct answer from the list below. Not all of the answers will be used.
-________________ is caused by a deficiency in vitamin B1.

Accepted Answer

A) scurvy 
B) phosphorylation 
C) beriberi 
D) mitochondria 
E) acetyl CoA
F)E3
G)thiamine pyrophosphate
H)lipoamide
I)pyruvate dehydrogenase
J)coenzyme A
K)E1
L)glyoxylate cycle 
A) scurvy 
B) phosphorylation 
C) beriberi 
D) mitochondria 
E) acetyl CoA
F)E3
G)thiamine pyrophosphate
H)lipoamide
I)pyruvate dehydrogenase
J)coenzyme A
K)E1
L)glyoxylate cycle

Question 20

A deficiency in the vitamin thiamine causes the disease ____________.

Accepted Answer

The answer of A deficiency in the vitamin thiamine causes...

Exam 18: Preparation for the Cycle

__________________ is the critical functional group of lipoamide responsible for carrying acetyl groups and maintaining the free energy of CoA.

Which of the following conditions will activate PDH kinase, which catalyzes the phorphorylation and inactivation of E1 in the PDH complex?

E2 of the PDH complex contains a lipoyl group that is covalently attached to a __________________ residue of the enzyme.

What are the three enzyme subunits in the PDH complex and the reactions they catalyze?

PDH is inactivated when it the enzyme is __________________.

Choose the correct answer from the list below. Not all of the answers will be used. -The activated carrier of acyl groups is ________________.

What are the two advantages that are derived from the coordinated actions of the three enzymes in the PDH complex?

__________________ inserts the lipoamide arm of the SH domain deep into the channel in E1.

E1 of the PDH complex requires the coenzyme __________________ for proper activity.

Decarboxylation, oxidation, and __________________ are the three steps critical to preserve the free energy derived from decarboxylation of the PDH complex.

Choose the correct answer from the list below. Not all of the answers will be used. -________________ provides a flexible linker between active siteswithin the pyruvate dehydrogenase (PDH) complex.

__________________ is the PDH subunit responsible for the regeneration of the oxidized form of lipoamide.

Choose the correct answer from the list below. Not all of the answers will be used. -The coenzyme ________________ is the prosthetic group in the decarboxylation of pyruvate.

Which enzyme(s) is/are responsible for the following reaction? Pyruvate + CoA + NAD+ → Acetyl CoA + NADH + H+ + CO2

The high-energy charge which results in increasing concentration of NADH __________________ the activity of PDH.

Choose the correct answer from the list below. Not all of the answers will be used. -________________ is a large, multi-subunit enzyme complex that links glycolysis and the citric acid cycle under aerobic conditions.

Review the fates of pyruvate and the cellular conditions that dictate these fates.

The citric acid cycle is also known as the:

Choose the correct answer from the list below. Not all of the answers will be used. -________________ is caused by a deficiency in vitamin B1.

A deficiency in the vitamin thiamine causes the disease ____________.

Biochemistry and the Unity of Life

Water, Weak Bonds, and the Generation of Order Out of Chaos

Amino Acids

Protein Three-Dimensional Structure

Techniques in Protein Biochemistry

Basic Concepts of Enzyme Action

Kinetics and Regulation

Mechanisms and Inhibitors

Hemoglobin: an Allosteric Protein

Carbohydrates

Lipids

Membrane Structure and Function

Signal Transduction Pathways

Digestion: Turning a Meal Into Cellular Biochemicals

Metabolism: Basic Concepts and Design

Glycolysis

Gluconeogenesis

Harvesting Electrons From the Cycle

The Electron Transport Chain

The Proton-Motive Force

The Light Reactions

The Calvin Cycle

Glycogen Degradation

Glycogen Synthesis

The Pentose Phosphate Pathway

Fatty Acid Degredation

Fatty Acid Synthesis

Lipid Synthesis

Amino Acid Degradation and the Urea Cycle

Amino Acids Synthesis

Nucleotide Metabolism

The Structure of Informational Macromolecules: Dna and Rna

DNA Replication

DNA Repair and Recombination

RNA Synthesis and Regulation in Prokaryotes

Gene Expression in Eukaryotes

RNA Processing in Eukaryotes

The Genetic Code

The Mechanism of Protein Synthesis

Recombinant DNA Techniques

Filters

Which of the following conditions will activate PDH kinase, which catalyzes the phorphorylation and inactivation of E₁ in the PDH complex?

E₂ of the PDH complex contains a lipoyl group that is covalently attached to a __________________ residue of the enzyme.

__________________ inserts the lipoamide arm of the SH domain deep into the channel in E₁.

E₁ of the PDH complex requires the coenzyme __________________ for proper activity.

Which enzyme(s) is/are responsible for the following reaction? Pyruvate + CoA + NAD⁺ → Acetyl CoA + NADH + H⁺ + CO₂