Question 1

Inosinate can be converted to:

Accepted Answer

A)  AMP. 
B)  GMP. 
C)  UMP. 
D)  A or B. 
E)  A, B, or C. 
A)  AMP. 
B)  GMP. 
C)  UMP. 
D)  A or B. 
E)  A, B, or C.

Question 2

Given the function of nucleotides, would you expect their synthesis to be simple or complex and diverse?

Accepted Answer

Simple, as these molecules were importan

Question 3

What is a general theme in purine ring synthesis, in terms of reaction logic and mechanism?

Accepted Answer

The first six steps are similar in that

Question 4

How is pyrimidine biosynthesis regulated?

Accepted Answer

Pyrimidine biosynthesis is regulated by

Question 5

The ultimate reductant in synthesis of deoxyribonucleotides is:

Accepted Answer

A)  FADH2. 
B)  NADH. 
C)  NADPH. 
D)  quinone. 
E)  None of the above. 
A)  FADH2. 
B)  NADH. 
C)  NADPH. 
D)  quinone. 
E)  None of the above.

Question 6

Use the following to answer questions 
Choose the correct answer from the list below. Not all of the answers will be used.
-Assembly of a compound from phophoribosylpyrophosphate (PRPP) and a base is known as a(n) _________________ pathway.

Accepted Answer

A) de novo 
B) xanthylate 
C) riboflavin 
D) amino acids 
E) UTP
F)N5, N10-methylenetetrahydrofolate
G)nucleotide
H)gout
I)nucleoside
J)ATP
K)urate
L)salvage 
A) de novo 
B) xanthylate 
C) riboflavin 
D) amino acids 
E) UTP
F)N5, N10-methylenetetrahydrofolate
G)nucleotide
H)gout
I)nucleoside
J)ATP
K)urate
L)salvage

Question 7

Use the following to answer questions 
Choose the correct answer from the list below. Not all of the answers will be used.
-The intermediate between inosinate and guanylate is _________________.

Accepted Answer

A) de novo 
B) xanthylate 
C) riboflavin 
D) amino acids 
E) UTP
F)N5, N10-methylenetetrahydrofolate
G)nucleotide
H)gout
I)nucleoside
J)ATP
K)urate
L)salvage 
A) de novo 
B) xanthylate 
C) riboflavin 
D) amino acids 
E) UTP
F)N5, N10-methylenetetrahydrofolate
G)nucleotide
H)gout
I)nucleoside
J)ATP
K)urate
L)salvage

Question 8

What is the advantage of channeling intermediates by carbamoyl phosphate synthetase?

Accepted Answer

There are three distinct sites in the en

Question 9

Which enzyme(s) catalyze(s) the first step in de novo nucleotide biosynthesis?

Accepted Answer

A)  aspartate transcarbamylase 
B)  nucleoside monophosphate kinase 
C)  glutamine phosphoribosyl amidotransferase 
D)  A and B 
E)  A and C 
A)  aspartate transcarbamylase 
B)  nucleoside monophosphate kinase 
C)  glutamine phosphoribosyl amidotransferase 
D)  A and B 
E)  A and C

Question 10

The conversion of ribonucleotides to deoxyribonucleotides is catalyzed by ________________.

Accepted Answer

ribonucleo

Question 11

Use the following to answer questions 
Choose the correct answer from the list below. Not all of the answers will be used.
-The final product of purine degradation is _________________.

Accepted Answer

A) de novo 
B) xanthylate 
C) riboflavin 
D) amino acids 
E) UTP
F)N5, N10-methylenetetrahydrofolate
G)nucleotide
H)gout
I)nucleoside
J)ATP
K)urate
L)salvage 
A) de novo 
B) xanthylate 
C) riboflavin 
D) amino acids 
E) UTP
F)N5, N10-methylenetetrahydrofolate
G)nucleotide
H)gout
I)nucleoside
J)ATP
K)urate
L)salvage

Question 12

Use the following to answer questions 
Choose the correct answer from the list below. Not all of the answers will be used.
-Purines and pyrimidines are derived from _________________.

Accepted Answer

A) de novo 
B) xanthylate 
C) riboflavin 
D) amino acids 
E) UTP
F)N5, N10-methylenetetrahydrofolate
G)nucleotide
H)gout
I)nucleoside
J)ATP
K)urate
L)salvage 
A) de novo 
B) xanthylate 
C) riboflavin 
D) amino acids 
E) UTP
F)N5, N10-methylenetetrahydrofolate
G)nucleotide
H)gout
I)nucleoside
J)ATP
K)urate
L)salvage

Question 13

Use the following to answer questions 
Choose the correct answer from the list below. Not all of the answers will be used.
-CTP is formed by the amination of _________________.

Accepted Answer

A) de novo 
B) xanthylate 
C) riboflavin 
D) amino acids 
E) UTP
F)N5, N10-methylenetetrahydrofolate
G)nucleotide
H)gout
I)nucleoside
J)ATP
K)urate
L)salvage 
A) de novo 
B) xanthylate 
C) riboflavin 
D) amino acids 
E) UTP
F)N5, N10-methylenetetrahydrofolate
G)nucleotide
H)gout
I)nucleoside
J)ATP
K)urate
L)salvage

Question 14

Use the following to answer questions 
Choose the correct answer from the list below. Not all of the answers will be used.
-Assembly of a compound from simpler molecules is known as a(n) _______________ pathway.

Accepted Answer

A) de novo 
B) xanthylate 
C) riboflavin 
D) amino acids 
E) UTP
F)N5, N10-methylenetetrahydrofolate
G)nucleotide
H)gout
I)nucleoside
J)ATP
K)urate
L)salvage 
A) de novo 
B) xanthylate 
C) riboflavin 
D) amino acids 
E) UTP
F)N5, N10-methylenetetrahydrofolate
G)nucleotide
H)gout
I)nucleoside
J)ATP
K)urate
L)salvage

Question 15

The synthesis of CTP from UTP requires UTP and:

Accepted Answer

A)  glutamine and ATP. 
B)  glycine and ATP. 
C)  glutamine, ATP, and NADH. 
D)  All of the above. 
E)  None of the above. 
A)  glutamine and ATP. 
B)  glycine and ATP. 
C)  glutamine, ATP, and NADH. 
D)  All of the above. 
E)  None of the above.

Question 16

The competitive inhibitor(s) of dihydrofolate reductase is/are:

Accepted Answer

A)  aminopterin 
B)  methotrexate 
C)  fluorouracil 
D)  A and B 
E)  B and C 
A)  aminopterin 
B)  methotrexate 
C)  fluorouracil 
D)  A and B 
E)  B and C

Question 17

The source(s) of NH2 groups in the synthesis of nucleotides is/are:

Accepted Answer

A)  aspartate 
B)  glutamine 
C)  glycine 
D)  A and B 
E)  A, B, and C 
A)  aspartate 
B)  glutamine 
C)  glycine 
D)  A and B 
E)  A, B, and C

Question 18

How is the reciprocal use of nucleotides useful in purine synthesis?

Accepted Answer

AMP synthesis requires GTP, wh

Question 19

How many ATP molecules are necessary to make carbamoyl phosphate by carbamoyl phosphate synthetase (CPS)?

Accepted Answer

A)  1 
B)  4 
C)  2 
D)  3 
E)  None of the above. 
A)  1 
B)  4 
C)  2 
D)  3 
E)  None of the above.

Question 20

DNA is built from __________________.

Accepted Answer

deoxyribon

Exam 32: Nucleotide Metabolism

Inosinate can be converted to:

Given the function of nucleotides, would you expect their synthesis to be simple or complex and diverse?

What is a general theme in purine ring synthesis, in terms of reaction logic and mechanism?

How is pyrimidine biosynthesis regulated?

The ultimate reductant in synthesis of deoxyribonucleotides is:

Use the following to answer questions Choose the correct answer from the list below. Not all of the answers will be used. -Assembly of a compound from phophoribosylpyrophosphate (PRPP) and a base is known as a(n) _________________ pathway.

Use the following to answer questions Choose the correct answer from the list below. Not all of the answers will be used. -The intermediate between inosinate and guanylate is _________________.

What is the advantage of channeling intermediates by carbamoyl phosphate synthetase?

Which enzyme(s) catalyze(s) the first step in de novo nucleotide biosynthesis?

The conversion of ribonucleotides to deoxyribonucleotides is catalyzed by ________________.

Use the following to answer questions Choose the correct answer from the list below. Not all of the answers will be used. -The final product of purine degradation is _________________.

Use the following to answer questions Choose the correct answer from the list below. Not all of the answers will be used. -Purines and pyrimidines are derived from _________________.

Use the following to answer questions Choose the correct answer from the list below. Not all of the answers will be used. -CTP is formed by the amination of _________________.

Use the following to answer questions Choose the correct answer from the list below. Not all of the answers will be used. -Assembly of a compound from simpler molecules is known as a(n) _______________ pathway.

The synthesis of CTP from UTP requires UTP and:

The competitive inhibitor(s) of dihydrofolate reductase is/are:

The source(s) of NH2 groups in the synthesis of nucleotides is/are:

How is the reciprocal use of nucleotides useful in purine synthesis?

How many ATP molecules are necessary to make carbamoyl phosphate by carbamoyl phosphate synthetase (CPS)?

DNA is built from __________________.

Biochemistry and the Unity of Life

Water, Weak Bonds, and the Generation of Order Out of Chaos

Amino Acids

Protein Three-Dimensional Structure

Techniques in Protein Biochemistry

Basic Concepts of Enzyme Action

Kinetics and Regulation

Mechanisms and Inhibitors

Hemoglobin: an Allosteric Protein

Carbohydrates

Lipids

Membrane Structure and Function

Signal Transduction Pathways

Digestion: Turning a Meal Into Cellular Biochemicals

Metabolism: Basic Concepts and Design

Glycolysis

Gluconeogenesis

Preparation for the Cycle

Harvesting Electrons From the Cycle

The Electron Transport Chain

The Proton-Motive Force

The Light Reactions

The Calvin Cycle

Glycogen Degradation

Glycogen Synthesis

The Pentose Phosphate Pathway

Fatty Acid Degredation

Fatty Acid Synthesis

Lipid Synthesis

Amino Acid Degradation and the Urea Cycle

Amino Acids Synthesis

The Structure of Informational Macromolecules: Dna and Rna

DNA Replication

DNA Repair and Recombination

RNA Synthesis and Regulation in Prokaryotes

Gene Expression in Eukaryotes

RNA Processing in Eukaryotes

The Genetic Code

The Mechanism of Protein Synthesis

Recombinant Dna Techniques

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