Exam 20: Mechanisms of Signal Transduction

Nuclear receptors:

Hormone action is ultimately controlled by the cells that secrete the hormone.

Which of the following does NOT belong to a receptor tyrosine kinase family?

Name the amino acid residue that is used to complex zinc ions in the zinc finger motif of steroid receptors.

The protein products of viral ________ are often components of signal transduction pathways that result in tumorigenesis.

Which of the following compounds can act as second messengers in signal transduction pathways?

Most synaptic transmission events are mediated electrically through gap junctions between cells.

The membrane-bound receptor in G protein-coupled signal transduction is quite separate to the effector enzyme which catalyses the formation of an intracellular ________.

The drug tamoxifen can be used as an anti-cancer drug in some breast tumors as it binds to the ________ but does not activate estrogen-responsive genes.

Steroid hormones are cytosolic ligands for a class of nuclear receptors that exert their effects by binding to specific sites on ________.

Receptor tyrosine kinases are membrane-spanning proteins with an intrinsic tyrosine kinase domain on the extracellular side of the membrane.

The end result of a signal transduction pathway is often a change in gene expression.

Which of the following is an extracellular messenger involved in signal transduction?

G proteins are membrane-bound proteins that bind GDP when inactive.