Question 1

Which of the following organisms would be best suited for undergoing chromosome walking to clone a gene based upon map position?

Accepted Answer

A)  C. elegans 
B)  Human 
C)  Mouse 
D)  Rhesus Monkey 
E)  C. elegans and Human 
A)  C. elegans 
B)  Human 
C)  Mouse 
D)  Rhesus Monkey 
E)  C. elegans and Human

Question 2

The SNPs on a chromosome segment that tend to be inherited together define a genetic unit called a:

Accepted Answer

A)  Phenotype 
B)  Genotype 
C)  Haplotype 
D)  Maplotype 
E)  Genome sequence 
A)  Phenotype 
B)  Genotype 
C)  Haplotype 
D)  Maplotype 
E)  Genome sequence

Question 3

Based on the sequencing data acquired from the Human Genome Project,what percentage of the human genome is comprised of exons,which will be translated into proteins?

Accepted Answer

A)  1.1% 
B)  24% 
C)  54% 
D)  75% 
E)  90% 
A)  1.1% 
B)  24% 
C)  54% 
D)  75% 
E)  90%

Question 4

Which subdiscipline based technology is known to fall under the term genomics?

Accepted Answer

A)  Mapping 
B)  Sequencing 
C)  Analyzing the functions of entire genomes 
D)  All of these 
E)  None of these 
A)  Mapping 
B)  Sequencing 
C)  Analyzing the functions of entire genomes 
D)  All of these 
E)  None of these

Question 5

A map that integrates the cytological,genetic and physical maps of a chromosome is referred to as:

Accepted Answer

A)  High density maps 
B)  High correlation maps 
C)  Correlated map structure 
D)  All of these 
E)  None of these 
A)  High density maps 
B)  High correlation maps 
C)  Correlated map structure 
D)  All of these 
E)  None of these

Question 6

Which of the following was not an initial goal of the Human Genome Project when it was organized in 1990?

Accepted Answer

A)  Map all the human genes 
B)  Construct a detailed physical map of the entire human genome 
C)  Determine nucleotide sequence of all 24 human chromosomes 
D)  Map the gene sequence of Francis Crick 
E)  All of these were initial goals 
A)  Map all the human genes 
B)  Construct a detailed physical map of the entire human genome 
C)  Determine nucleotide sequence of all 24 human chromosomes 
D)  Map the gene sequence of Francis Crick 
E)  All of these were initial goals

Question 7

As eukaryotic organisms have increased in complexity,the proportion of their genomes that encodes proteins has:

Accepted Answer

A)  Increased 
B)  Decreased 
C)  Stayed the same 
D)  Increased in complexity 
E)  Decreased in complexity 
A)  Increased 
B)  Decreased 
C)  Stayed the same 
D)  Increased in complexity 
E)  Decreased in complexity

Question 8

Which of the following is a bioinformatics tool?

Accepted Answer

A)  BLAST search 
B)  GENBANK 
C)  Microarray hybridization 
D)  BLAST search and GENBANK 
E)  All of these 
A)  BLAST search 
B)  GENBANK 
C)  Microarray hybridization 
D)  BLAST search and GENBANK 
E)  All of these

Question 9

Which of the following men are responsible for the rapid progress of the sequencing activities of the Human Genome Project?

Accepted Answer

A)  Francis Collins 
B)  Craig Venter 
C)  James Watson 
D)  Francis Collins and Craig Venter 
E)  Francis Collins and James Watson 
A)  Francis Collins 
B)  Craig Venter 
C)  James Watson 
D)  Francis Collins and Craig Venter 
E)  Francis Collins and James Watson

Question 10

Overlapping genomic clones found in physical chromosome maps are also known as:

Accepted Answer

A)  STSs 
B)  Contigs 
C)  ORI sites 
D)  Polylinkers 
E)  All of these 
A)  STSs 
B)  Contigs 
C)  ORI sites 
D)  Polylinkers 
E)  All of these

Question 11

The most common changes in human genomes are single nucleotide-pair substitutions such as A:T to G:C or G:C to A:T substitutions.These are known as:

Accepted Answer

A)  NSPs 
B)  VNTRs 
C)  STRs 
D)  SNPs 
E)  ESTs 
A)  NSPs 
B)  VNTRs 
C)  STRs 
D)  SNPs 
E)  ESTs

Question 12

Which of the following procedures is a variation on FISH and has been used for comparative genome analysis on some species?

Accepted Answer

A)  Recombination mapping 
B)  Chromosome jumping 
C)  Chromosome painting 
D)  Chromosome fluorescence 
E)  Chromosome walking 
A)  Recombination mapping 
B)  Chromosome jumping 
C)  Chromosome painting 
D)  Chromosome fluorescence 
E)  Chromosome walking

Question 13

Short cDNA sequences used as hybridization probes to anchor physical maps to genetic and cytological maps of chromosomes are known as:

Accepted Answer

A)  STSs 
B)  ORIs 
C)  PCRs 
D)  STRs 
E)  ESTs 
A)  STSs 
B)  ORIs 
C)  PCRs 
D)  STRs 
E)  ESTs

Question 14

The ability of scientists to identify and isolate genes based on information about their location in the genome is known as:

Accepted Answer

A)  Functional mapping 
B)  Positional cloning 
C)  Positional mapping 
D)  Microarray analysis 
E)  None of these 
A)  Functional mapping 
B)  Positional cloning 
C)  Positional mapping 
D)  Microarray analysis 
E)  None of these

Question 15

Which of the following techniques can be used to position clones on a cytological map?

Accepted Answer

A)  Southern blotting 
B)  Northern blotting 
C)  In situ hybridization 
D)  Western blotting 
E)  PCR 
A)  Southern blotting 
B)  Northern blotting 
C)  In situ hybridization 
D)  Western blotting 
E)  PCR

Question 16

Which of the following is used to construct a physical map of a chromosome
1)Recombination frequencies
2)Banding patterns of chromosomes
3)Molecular distances separating sites on a DNA fragment

Accepted Answer

A)  1 
B)  2 
C)  3 
D)  1 and 3 
E)  All of these 
A)  1 
B)  2 
C)  3 
D)  1 and 3 
E)  All of these

Question 17

Homologous genes within a species are known as:

Accepted Answer

A)  Paralogues 
B)  Orthologues 
C)  Heterologues 
D)  Similogues 
E)  None of these 
A)  Paralogues 
B)  Orthologues 
C)  Heterologues 
D)  Similogues 
E)  None of these

Question 18

Within the euchromatic regions of human chromosomes one CentiMorgan is equivalent,on average,to what physical distance of DNA?

Accepted Answer

A)  1mb 
B)  1kb 
C)  1mm 
D)  1cm 
E)  10mb 
A)  1mb 
B)  1kb 
C)  1mm 
D)  1cm 
E)  10mb

Question 19

Which of the following could be a result of studying the SNPs in the human genome?
1)It may be possible to trace important genetic events in the evolutionary history of our species
2)It may be possible to predict a person's susceptibility to diseases like cancer and heart disease
3)It may be possible to track human ancestry

Accepted Answer

A)  1 
B)  2 
C)  3 
D)  1 and 2 
E)  All of these 
A)  1 
B)  2 
C)  3 
D)  1 and 2 
E)  All of these

Question 20

How is positional cloning conducted in order to clone a gene that is moderately expressed?

Accepted Answer

The gene is first mapped to a specific r

Exam 15: Genomics

Which of the following organisms would be best suited for undergoing chromosome walking to clone a gene based upon map position?

The SNPs on a chromosome segment that tend to be inherited together define a genetic unit called a:

Based on the sequencing data acquired from the Human Genome Project,what percentage of the human genome is comprised of exons,which will be translated into proteins?

Which subdiscipline based technology is known to fall under the term genomics?

A map that integrates the cytological,genetic and physical maps of a chromosome is referred to as:

Which of the following was not an initial goal of the Human Genome Project when it was organized in 1990?

As eukaryotic organisms have increased in complexity,the proportion of their genomes that encodes proteins has:

Which of the following is a bioinformatics tool?

Which of the following men are responsible for the rapid progress of the sequencing activities of the Human Genome Project?

Overlapping genomic clones found in physical chromosome maps are also known as:

The most common changes in human genomes are single nucleotide-pair substitutions such as A:T to G:C or G:C to A:T substitutions.These are known as:

Which of the following procedures is a variation on FISH and has been used for comparative genome analysis on some species?

Short cDNA sequences used as hybridization probes to anchor physical maps to genetic and cytological maps of chromosomes are known as:

The ability of scientists to identify and isolate genes based on information about their location in the genome is known as:

Which of the following techniques can be used to position clones on a cytological map?

Which of the following is used to construct a physical map of a chromosome 1)Recombination frequencies 2)Banding patterns of chromosomes 3)Molecular distances separating sites on a DNA fragment

Homologous genes within a species are known as:

Within the euchromatic regions of human chromosomes one CentiMorgan is equivalent,on average,to what physical distance of DNA?

How is positional cloning conducted in order to clone a gene that is moderately expressed?

The Science Of Genetics

Cellular Reproduction

Mendelism The Basic Principles Of Inheritance

Extensions Of Mendelism

The Chromosomal Basis Of Mendelism

Variation In Chromosome Number And Structure

Linkage,Crossing Over,And Chromosome Mapping In …

The Genetics Of Bacteria And Their Viruses

DNA And The Molecular Structure Of Chromosomes

Replication Of DNA And Chromosomes

Transcription And RNA Processing

Translation And The Genetic Code

Mutation,DNA Repair,And Recombination

The Techniques Of Molecular Genetics

Applications Of Molecular Genetics

Transposable Genetics Elements

Regulation Of Gene Expression In Prokaryotes

Regulation Of Gene Expression In Eukaryotes

The Genetic Control Of Animal Development

The Genetic Basis Of Cancer

Inheritance Of Complex Traits

Population Genetics

Evolutionary Genetics

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