Exam 5: Amyloidosis

A 58 year old woman was seen by a nephrologist for chronic renal failure.She had a 20 year history of rheumatoid arthritis.A renal biopsy was performed,and a representative glomerulus is shown in the accompanying photomicrograph,stained with Sirius Red.Which one of the following is the best diagnosis for the cause of her renal failure?

A 37 year old woman died of congestive heart failure.An autopsy was requested by the family because her sister had also died at a young age of congestive heart failure.At autopsy,the heart was enlarged,and had a waxy,pale appearance.A representative section is shown in the accompanying photomicrograph.Which one of the following is the best diagnosis?

Most of the proteins that form amyloid in human tissue do so because of their molecular configuration.Which one of the following is the typical protein quaternary structure required to form the deposits known as amyloid?