Exam 4: Properties of Drugs

_____________ tolerance consists of a decreased behavioral responsivess to a drug's effects.

The selective destruction of axons by a neurotoxin is called:

__________________ refers to a drug's ability to activate a receptor.

List and describe four ways that a drug could alter neurotransmission.

Which administration route provides the greatest drug absorption?

If a drug is found in the brain but does not possess the properties needed for passive diffusion through the blood-brain barrier then a researcher should conclude:

__________________ tolerance occurs as a physiological response to stimuli associated with substance use that serves to counteract a drug's physiological actions.

An administration route preferred by patients and easy to administer is:

A positive allosteric modulator:

A(n)__________________ inhibitor prevents the passage of a neurotransmitter through a membrane transporter.

The steps in pharmacokinetics normally occur in what sequence?

The surface area of a membrane can:

Analyzing the amount of psychoactive drug in brain tissue would allow a researcher to determine:

Describe the differences between first-order kinetics and zero-order kinetics and provide an example.

A drug that is catabolized by enzymes into multiple metabolites before reaching its site of action likely:

The term liberation describes the diffusion of drugs through membranes.

_____________ tolerance consists of a reduced responsiveness to a drug at the drug's site of action.

A ternary receptor model suggests that:

The particular membrane that a drug must pass through depends on the drug's __________________.

List and define the two types of dependence presented in the book.Provide an example of an effect for each type.