Question 1

Psychoactive drugs rely on active transport mechanisms to cross the blood-brain barrier.

Accepted Answer

A) True 
 B)False

Question 2

The process of ____________ refers to the passage of a drug from the site of administration to the bloodstream.

Accepted Answer

A)  distribution 
B)  absorption 
C)  metabolism 
D)  elimination 
A)  distribution 
B)  absorption 
C)  metabolism 
D)  elimination

Question 3

Preventing neurotransmitter reuptake will reduce neurotransmitter synthesis.

Accepted Answer

A) True 
 B)False

Question 4

______________ is the process of converting a drug into one or more metabolites.

Accepted Answer

A)  Nonspecific binding 
B)  Distribution 
C)  Active transport 
D)  Biotransformation 
A)  Nonspecific binding 
B)  Distribution 
C)  Active transport 
D)  Biotransformation

Question 5

The passage of a drug from the bloodstream to sites in the body is called:

Accepted Answer

A)  distribution. 
B)  absorption. 
C)  administration. 
D)  biotransformation 
A)  distribution. 
B)  absorption. 
C)  administration. 
D)  biotransformation

Question 6

Drug A has a Kd=100,Drug B has a Kd=10,Drug C has a Kd=5,and Drug D has a Kd = 1.Which drug has a greatest affinity for a receptor?

Accepted Answer

A)  Drug A 
B)  Drug B 
C)  Drug C 
D)  Drug D 
A)  Drug A 
B)  Drug B 
C)  Drug C 
D)  Drug D

Question 7

If a drug was present in the bloodstream but unable to cross the blood-brain barrier,then one could conclude:

Accepted Answer

A)  that nonspecific binding occurred. 
B)  the drug could enter the brain using active transport mechanisms. 
C)  the drug's pKa had matched the pH of the physiological medium it was administered in. 
D)  the drug was not small, non-charged or lipid soluble. 
A)  that nonspecific binding occurred. 
B)  the drug could enter the brain using active transport mechanisms. 
C)  the drug's pKa had matched the pH of the physiological medium it was administered in. 
D)  the drug was not small, non-charged or lipid soluble.

Question 8

A person needed a drug to avoid withdrawal symptoms is an example of:

Accepted Answer

A)  sensitization. 
B)  tolerance. 
C)  conditioning. 
D)  dependence. 
A)  sensitization. 
B)  tolerance. 
C)  conditioning. 
D)  dependence.

Question 9

A negative modulator prevents a neurotransmitter from activating a receptor.

Accepted Answer

A) True 
 B)False

Question 10

The process of drug molecules separating from the pill or solution it was delivered in is called:

Accepted Answer

A)  pKa. 
B)  administration 
C)  liberation. 
D)  passive diffusion. 
A)  pKa. 
B)  administration 
C)  liberation. 
D)  passive diffusion.

Question 11

A pharmacologist sought to develop a drug to act as a negative modulator.Which of the following describes the most likely outcome for the proposed drug?

Accepted Answer

A)  The drug will prevent activation of G-proteins 
B)  The drug will block neurotransmission 
C)  The drug will counteract the effects of an antagonist 
D)  The drug will weaken, but not prevent, neurotransmission 
A)  The drug will prevent activation of G-proteins 
B)  The drug will block neurotransmission 
C)  The drug will counteract the effects of an antagonist 
D)  The drug will weaken, but not prevent, neurotransmission

Question 12

A drug eliminated in half-lives follows:

Accepted Answer

A)  first-order kinetics. 
B)  second-order kinetics. 
C)  zero-order kinetics. 
D)  linear kinetics. 
A)  first-order kinetics. 
B)  second-order kinetics. 
C)  zero-order kinetics. 
D)  linear kinetics.

Question 13

The collection of withdrawal symptoms expected from a particular drug is referred to as:

Accepted Answer

A)  dispositional tolerance. 
B)  a withdrawal syndrome. 
C)  conditioned tolerance. 
D)  dependence. 
A)  dispositional tolerance. 
B)  a withdrawal syndrome. 
C)  conditioned tolerance. 
D)  dependence.

Question 14

________________ tolerance occurs as a physiological response to stimuli associated with substance use,serving to elicit actions that counteract a drug's effects.

Accepted Answer

A)  Pharmacokinetic 
B)  Physical 
C)  Behavioral 
D)  Conditioned 
A)  Pharmacokinetic 
B)  Physical 
C)  Behavioral 
D)  Conditioned

Question 15

A drug found to bind to the NMDA receptor might be a positive allosteric modulator if:

Accepted Answer

A)  some of the receptors the drug binded to became activated while others were not. 
B)  the drug alone caused ions to flow through the NMDA receptor channel. 
C)  reduced ion flow through the NMDA receptor channel occurred when glutamate was bound to the receptor with the drug present. 
D)  greater ion flow through the NMDA receptor occurred when glutamate was bound to the receptor with the drug present. 
A)  some of the receptors the drug binded to became activated while others were not. 
B)  the drug alone caused ions to flow through the NMDA receptor channel. 
C)  reduced ion flow through the NMDA receptor channel occurred when glutamate was bound to the receptor with the drug present. 
D)  greater ion flow through the NMDA receptor occurred when glutamate was bound to the receptor with the drug present.

Question 16

Researchers discovered that a psychoactive drug's effects were entirely accounted for by its metabolites.Given this,then drug was likely:

Accepted Answer

A)  eliminated by zero-order kinetics. 
B)  a non-active metabolite. 
C)  a placebo. 
D)  a prodrug. 
A)  eliminated by zero-order kinetics. 
B)  a non-active metabolite. 
C)  a placebo. 
D)  a prodrug.

Question 17

The drug xanazine:

Accepted Answer

A)  inhibits passage of dopamine through vesicular transporters. 
B)  inhibits reuptake of dopamine. 
C)  inhibits binding of dopamine to receptors. 
D)  inhibits synthesis of dopamine. 
A)  inhibits passage of dopamine through vesicular transporters. 
B)  inhibits reuptake of dopamine. 
C)  inhibits binding of dopamine to receptors. 
D)  inhibits synthesis of dopamine.

Question 18

A metabolite that has physiological effects was like produced through:

Accepted Answer

A)  Phase I biotransformation. 
B)  Phase II biotransformation. 
C)  nonspecific binding. 
D)  passive diffusion. 
A)  Phase I biotransformation. 
B)  Phase II biotransformation. 
C)  nonspecific binding. 
D)  passive diffusion.

Question 19

Blocking postsynaptic receptors for neurotransmission to prevent neurotransmission.

Accepted Answer

A) True 
 B)False

Question 20

A drug's strength of binding to a receptor can be determined by:

Accepted Answer

A)  conducting an experiment to assess receptor efficacy. 
B)  conducting an experiment to determine if the drug is an allosteric modulator. 
C)  conducting a binding affinity experiment. 
D)  conducting a ternary receptor model experiment. 
A)  conducting an experiment to assess receptor efficacy. 
B)  conducting an experiment to determine if the drug is an allosteric modulator. 
C)  conducting a binding affinity experiment. 
D)  conducting a ternary receptor model experiment.

Psychoactive drugs rely on active transport mechanisms to cross the blood-brain barrier.

The process of ____________ refers to the passage of a drug from the site of administration to the bloodstream.

Preventing neurotransmitter reuptake will reduce neurotransmitter synthesis.

______________ is the process of converting a drug into one or more metabolites.

The passage of a drug from the bloodstream to sites in the body is called:

Drug A has a Kd=100,Drug B has a Kd=10,Drug C has a Kd=5,and Drug D has a Kd = 1.Which drug has a greatest affinity for a receptor?

If a drug was present in the bloodstream but unable to cross the blood-brain barrier,then one could conclude:

A person needed a drug to avoid withdrawal symptoms is an example of:

A negative modulator prevents a neurotransmitter from activating a receptor.

The process of drug molecules separating from the pill or solution it was delivered in is called:

A pharmacologist sought to develop a drug to act as a negative modulator.Which of the following describes the most likely outcome for the proposed drug?

A drug eliminated in half-lives follows:

The collection of withdrawal symptoms expected from a particular drug is referred to as:

________________ tolerance occurs as a physiological response to stimuli associated with substance use,serving to elicit actions that counteract a drug's effects.

A drug found to bind to the NMDA receptor might be a positive allosteric modulator if:

Researchers discovered that a psychoactive drug's effects were entirely accounted for by its metabolites.Given this,then drug was likely:

The drug xanazine:

A metabolite that has physiological effects was like produced through:

Blocking postsynaptic receptors for neurotransmission to prevent neurotransmission.

A drug's strength of binding to a receptor can be determined by:

Introduction to Psychopharmacology

The Nervous System

Neurotransmission

Drugs of Abuse

Psychostimulants

Nicotine and Caffeine

Alcohol

GHP and Inhalants

Opioids

Cannabinoids

Psychedelic Drugs

Treatments for Depression and Bipolar Disorder

Treatments for Anxiety Disorders

Antipsychotic Drugs

Filters

Exam 4: Properties of Drugs

Psychoactive drugs rely on active transport mechanisms to cross the blood-brain barrier.

The process of ____________ refers to the passage of a drug from the site of administration to the bloodstream.

Preventing neurotransmitter reuptake will reduce neurotransmitter synthesis.

______________ is the process of converting a drug into one or more metabolites.

The passage of a drug from the bloodstream to sites in the body is called:

Drug A has a Kd=100,Drug B has a Kd=10,Drug C has a Kd=5,and Drug D has a Kd = 1.Which drug has a greatest affinity for a receptor?

If a drug was present in the bloodstream but unable to cross the blood-brain barrier,then one could conclude:

A person needed a drug to avoid withdrawal symptoms is an example of:

A negative modulator prevents a neurotransmitter from activating a receptor.

The process of drug molecules separating from the pill or solution it was delivered in is called:

A pharmacologist sought to develop a drug to act as a negative modulator.Which of the following describes the most likely outcome for the proposed drug?

A drug eliminated in half-lives follows:

The collection of withdrawal symptoms expected from a particular drug is referred to as:

________________ tolerance occurs as a physiological response to stimuli associated with substance use,serving to elicit actions that counteract a drug's effects.

A drug found to bind to the NMDA receptor might be a positive allosteric modulator if:

Researchers discovered that a psychoactive drug's effects were entirely accounted for by its metabolites.Given this,then drug was likely:

The drug xanazine:

A metabolite that has physiological effects was like produced through:

Blocking postsynaptic receptors for neurotransmission to prevent neurotransmission.

A drug's strength of binding to a receptor can be determined by:

Introduction to Psychopharmacology

The Nervous System

Neurotransmission

Drugs of Abuse

Psychostimulants

Nicotine and Caffeine

Alcohol

GHP and Inhalants

Opioids

Cannabinoids

Psychedelic Drugs

Treatments for Depression and Bipolar Disorder

Treatments for Anxiety Disorders

Antipsychotic Drugs

Filters