Exam 15: Gene Mutation,dna Repair,and Transposition

Strand discrimination during the process of DNA repair is based on DNA methylation in E.coli.

Which of the following name two mutagens that would be classified as base analogs?

Assume that a new mutation occurs in the germ line of an individual.What finding would suggest that the new mutation is dominant rather than recessive?

Of the two cell lines that can contain a mutation in an organism,somatic and germ line,the latter is more consequential to subsequent generations.

It has been found that a particular "+ -" combination of frameshift mutations in gene X gives a wild-type phenotype,whereas a "- +" combination gives a mutant phenotype,even though the sites of insertion/deletion are the same.How might these results be explained?

Transposons,or jumping genes,are DNA elements that move within the genome.In which organismic groups are transposons found?

In a survey of 240,000 human births,six achondroplastic births were recorded to parents who were unaffected.Given that this form of dwarfism is caused by a fully penetrant,dominant,autosomal gene,what is the mutation rate?

Nutritional mutations can be defined as ________.

Apurinic sites (AP sites)involve a spontaneous loss of a(n)________ in an intact double-helix DNA molecule.

How were insertion sequences (IS elements)first discovered?

A missense mutation causes premature chain (protein)termination.

The process of error correction of mismatched bases carried out by DNA polymerases is called ________.

A mutation that occurs naturally,without exposure to a known mutagen,is called a(n)________.