Question 1

Long-lived plasma cells are most likely to be produced in response to:

Accepted Answer

A)  Thymic-dependent antigens 
B)  Type I thymic-independent antigens 
C)  Type II thymic-independent antigens 
D)  Both thymic-dependent and thymic-independent antigens result in production of long-lived plasma cells 
A)  Thymic-dependent antigens 
B)  Type I thymic-independent antigens 
C)  Type II thymic-independent antigens 
D)  Both thymic-dependent and thymic-independent antigens result in production of long-lived plasma cells A

Question 2

Most long-lived plasma cells reside in the:

Accepted Answer

A)  Spleen 
B)  Thymus 
C)  Lymph node 
D)  Bone marrow 
A)  Spleen 
B)  Thymus 
C)  Lymph node 
D)  Bone marrow D

Question 3

X-linked agammaglobulinemia results from a defect in:

Accepted Answer

A)  IL-7 gene 
B)  BTK gene 
C)  BLyS gene 
D)  CD22 gene 
A)  IL-7 gene 
B)  BTK gene 
C)  BLyS gene 
D)  CD22 gene B

Question 4

Belimumab is a monoclonal antibody directed against:

Accepted Answer

A)  BLyS 
B)  CD22 
C)  Bruton's kinase 
D)  BLyS and APRIL 
A)  BLyS 
B)  CD22 
C)  Bruton's kinase 
D)  BLyS and APRIL

Question 5

Which two cytokines are the main stimuli for B cell differentiation into plasma cells?

Accepted Answer

A)  TNF and IL-1 
B)  TACI and BLyS 
C)  BLyS and APRIL 
D)  TLR-4 and Lipid A 
A)  TNF and IL-1 
B)  TACI and BLyS 
C)  BLyS and APRIL 
D)  TLR-4 and Lipid A

Question 6

Which of the following are components of the BCR co-receptor complex? 
I. CR2
II. CD19
III. CD22

Accepted Answer

A)  I only 
B)  III only 
C)  I and II 
D)  II and III 
E)  I, II, and III 
A)  I only 
B)  III only 
C)  I and II 
D)  II and III 
E)  I, II, and III

Question 7

The phosphorylated immuno-receptor tyrosine-based activation motifs (ITAMs) of the BCR serve as a docking site for what adaptor protein?

Accepted Answer

A)  Syk 
B)  NFAT 
C)  ZAP-70 
D)  Src kinase 
A)  Syk 
B)  NFAT 
C)  ZAP-70 
D)  Src kinase

Question 8

What is the function of the BCR co-receptor complex?

Accepted Answer

A)  Stimulate isotype switching 
B)  Binding to antigen presenting cells (APCs) 
C)  Crosslinking of BCRs for signal amplification 
D)  Recruitment of adaptor proteins to carry signal to nucleus 
A)  Stimulate isotype switching 
B)  Binding to antigen presenting cells (APCs) 
C)  Crosslinking of BCRs for signal amplification 
D)  Recruitment of adaptor proteins to carry signal to nucleus

Question 9

Which of the following is an example of a type I thymus-independent antigen?

Accepted Answer

A)  Bacterial enzyme 
B)  Viral protein coat 
C)  Lipopolysaccharide (LPS) 
D)  Pneumococcal capsular polysaccharide 
A)  Bacterial enzyme 
B)  Viral protein coat 
C)  Lipopolysaccharide (LPS) 
D)  Pneumococcal capsular polysaccharide

Question 10

Why is crosslinking of BCRs important for B cell activation? 
I. Crosslinking of BCRs allows for antigen presenting cells to bind to B cells
II. Crosslinking of BCRs must occur before the BCRs can bind to their matching antigen
III. Crosslinking of BCRs properly positions signaling molecules to carry the signal deeper into the cytoplasm

Accepted Answer

A)  I only 
B)  III only 
C)  I and II 
D)  II and III 
E)  I, II, and III 
A)  I only 
B)  III only 
C)  I and II 
D)  II and III 
E)  I, II, and III

Long-lived plasma cells are most likely to be produced in response to:

Most long-lived plasma cells reside in the:

X-linked agammaglobulinemia results from a defect in:

Belimumab is a monoclonal antibody directed against:

Which two cytokines are the main stimuli for B cell differentiation into plasma cells?

Which of the following are components of the BCR co-receptor complex? I. CR2 II. CD19 III. CD22

The phosphorylated immuno-receptor tyrosine-based activation motifs (ITAMs) of the BCR serve as a docking site for what adaptor protein?

What is the function of the BCR co-receptor complex?

Which of the following is an example of a type I thymus-independent antigen?

Cells and Organs of the Immune System

Innate Immunity

Immunogenicity and Antigenicity

Antigen Presenting Molecules

Antigen Presenting Cells

Surface Interactions Between T Cells and Antigen-Presenting Cells

Intracellular Signaling and T Cell Activation

Antibodies

Antibody Diversity

Complement

Phagocytosis and Intracellular Killing

Antibodies and in Vivo Therapy

Antibodies and in Vitro Research and Diagnostic Assays

Immediate Allergic Reactions

Autoimmunity

Transplantation

Antigen Presentation for Cell-Mediated Response

Delayed Type Hypersensitivity Reactions

Cytotoxic T Cells

Natural Killer Cells

Factors That Influence the Immune Response

Cytokines and Biological Modifiers

Vaccines in Theory and Practice

Vaccine-Preventable Diseases

Acquired Immune Deficiency Syndrome

Filters

Exam 8: B Cell Activation and Signaling

Long-lived plasma cells are most likely to be produced in response to:

Most long-lived plasma cells reside in the:

X-linked agammaglobulinemia results from a defect in:

Belimumab is a monoclonal antibody directed against:

Which two cytokines are the main stimuli for B cell differentiation into plasma cells?

Which of the following are components of the BCR co-receptor complex? I. CR2 II. CD19 III. CD22

The phosphorylated immuno-receptor tyrosine-based activation motifs (ITAMs) of the BCR serve as a docking site for what adaptor protein?

What is the function of the BCR co-receptor complex?

Which of the following is an example of a type I thymus-independent antigen?

Cells and Organs of the Immune System

Innate Immunity

Immunogenicity and Antigenicity

Antigen Presenting Molecules

Antigen Presenting Cells

Surface Interactions Between T Cells and Antigen-Presenting Cells

Intracellular Signaling and T Cell Activation

Antibodies

Antibody Diversity

Complement

Phagocytosis and Intracellular Killing

Antibodies and in Vivo Therapy

Antibodies and in Vitro Research and Diagnostic Assays

Immediate Allergic Reactions

Autoimmunity

Transplantation

Antigen Presentation for Cell-Mediated Response

Delayed Type Hypersensitivity Reactions

Cytotoxic T Cells

Natural Killer Cells

Factors That Influence the Immune Response

Cytokines and Biological Modifiers

Vaccines in Theory and Practice

Vaccine-Preventable Diseases

Acquired Immune Deficiency Syndrome

Filters