Question 1

Production of a neoantigen would result from:

Accepted Answer

A)  Fungal infection 
B)  Genetic mutation 
C)  Presence of endotoxins 
D)  Processing of parasitic antigens 
A)  Fungal infection 
B)  Genetic mutation 
C)  Presence of endotoxins 
D)  Processing of parasitic antigens B

Question 2

Genetic factors that influence immunogenicity include:
I- Decreased functional capacity of the immune system over time
II- Lack of a T cell clone with a TCR that reacts to the antigen
III- Defect in antigen processing and antigen presentation

Accepted Answer

A)  I only 
B)  III only 
C)  I and II 
D)  II and III 
E)  I, II, and III 
A)  I only 
B)  III only 
C)  I and II 
D)  II and III 
E)  I, II, and III D

Question 3

Which of the following represents a conformational epitope?

Accepted Answer

A)  A mannose residue 
B)  Primary sequence of a short peptide 
C)  Long chain carbon segment of a lipid 
D)  Segment of two neighboring loops of a hemoglobin molecule 
A)  A mannose residue 
B)  Primary sequence of a short peptide 
C)  Long chain carbon segment of a lipid 
D)  Segment of two neighboring loops of a hemoglobin molecule D

Question 4

RhoGAM administered to an Rh-negative mother would help the patient by:
I- Preventing production of anti-Rh antibodies
II- Preventing fetal hemolysis in future pregnancies
III- Preventing transfusion reactions due to ABO mismatch

Accepted Answer

A)  I only 
B)  III only 
C)  I and II 
D)  II and III 
E)  I, II, and III 
A)  I only 
B)  III only 
C)  I and II 
D)  II and III 
E)  I, II, and III

Question 5

Which of the following drugs can react with red blood cells (RBCs) to cause hemolysis?

Accepted Answer

A)  Penicillin 
B)  Tetracycline 
C)  Tolbutamide 
D)  Procainamide 
A)  Penicillin 
B)  Tetracycline 
C)  Tolbutamide 
D)  Procainamide

Question 6

Which of the following would be considered the best immunogen?

Accepted Answer

A)  Mannose 
B)  Viral DNA 
C)  Surface protein on a parasite 
D)  Lipid components of fungal membrane 
A)  Mannose 
B)  Viral DNA 
C)  Surface protein on a parasite 
D)  Lipid components of fungal membrane

Question 7

Isoantigens found on red blood cells (RBCs) may lead to a hemolytic transfusion reaction because:

Accepted Answer

A)  CD4+ T cells and macrophages mediate an inflammatory response 
B)  Individuals have antibodies to the ABO antigens they do not express 
C)  CD8+ T cells recognize the isoantigens as foreign and destroy the RBC 
D)  The isoantigens are metabolized to reactive metabolites that cause an allergic reaction 
A)  CD4+ T cells and macrophages mediate an inflammatory response 
B)  Individuals have antibodies to the ABO antigens they do not express 
C)  CD8+ T cells recognize the isoantigens as foreign and destroy the RBC 
D)  The isoantigens are metabolized to reactive metabolites that cause an allergic reaction

Question 8

When a low molecular weight (<3000 Da) pharmaceutical agent binds to albumin, the pharmaceutical agent is acting as a/an:

Accepted Answer

A)  Hapten 
B)  Allergen 
C)  Immunogen 
D)  Carrier protein 
A)  Hapten 
B)  Allergen 
C)  Immunogen 
D)  Carrier protein

Question 9

How would you treat a mother with type A Rh-negative blood who is pregnant with a type O Rh-positive baby?

Accepted Answer

A)  A dose of RhoGAM at 28 weeks and following delivery 
B)  A high dose of RhoGAM and then a low dose of RhoGAM 
C)  A dose of RhoGAM only if there is a trauma or premature termination of pregnancy 
D)  RhoGAM is not necessary in this situation because there is no compatibility issue 
A)  A dose of RhoGAM at 28 weeks and following delivery 
B)  A high dose of RhoGAM and then a low dose of RhoGAM 
C)  A dose of RhoGAM only if there is a trauma or premature termination of pregnancy 
D)  RhoGAM is not necessary in this situation because there is no compatibility issue

Question 10

Which of the following is an example of an endogenous antigen?

Accepted Answer

A)  Viral protein 
B)  Fungal cell wall 
C)  Protein exotoxins 
D)  Bacterial endotoxin 
A)  Viral protein 
B)  Fungal cell wall 
C)  Protein exotoxins 
D)  Bacterial endotoxin

Production of a neoantigen would result from:

Genetic factors that influence immunogenicity include: I- Decreased functional capacity of the immune system over time II- Lack of a T cell clone with a TCR that reacts to the antigen III- Defect in antigen processing and antigen presentation

Which of the following represents a conformational epitope?

RhoGAM administered to an Rh-negative mother would help the patient by: I- Preventing production of anti-Rh antibodies II- Preventing fetal hemolysis in future pregnancies III- Preventing transfusion reactions due to ABO mismatch

Which of the following drugs can react with red blood cells (RBCs) to cause hemolysis?

Which of the following would be considered the best immunogen?

Isoantigens found on red blood cells (RBCs) may lead to a hemolytic transfusion reaction because:

When a low molecular weight (<3000 Da) pharmaceutical agent binds to albumin, the pharmaceutical agent is acting as a/an:

How would you treat a mother with type A Rh-negative blood who is pregnant with a type O Rh-positive baby?

Which of the following is an example of an endogenous antigen?

Cells and Organs of the Immune System

Innate Immunity

Antigen Presenting Molecules

Antigen Presenting Cells

Surface Interactions Between T Cells and Antigen-Presenting Cells

Intracellular Signaling and T Cell Activation

B Cell Activation and Signaling

Antibodies

Antibody Diversity

Complement

Phagocytosis and Intracellular Killing

Antibodies and in Vivo Therapy

Antibodies and in Vitro Research and Diagnostic Assays

Immediate Allergic Reactions

Autoimmunity

Transplantation

Antigen Presentation for Cell-Mediated Response

Delayed Type Hypersensitivity Reactions

Cytotoxic T Cells

Natural Killer Cells

Factors That Influence the Immune Response

Cytokines and Biological Modifiers

Vaccines in Theory and Practice

Vaccine-Preventable Diseases

Acquired Immune Deficiency Syndrome

Filters

Exam 3: Immunogenicity and Antigenicity

Production of a neoantigen would result from:

Genetic factors that influence immunogenicity include: I- Decreased functional capacity of the immune system over time II- Lack of a T cell clone with a TCR that reacts to the antigen III- Defect in antigen processing and antigen presentation

Which of the following represents a conformational epitope?

RhoGAM administered to an Rh-negative mother would help the patient by: I- Preventing production of anti-Rh antibodies II- Preventing fetal hemolysis in future pregnancies III- Preventing transfusion reactions due to ABO mismatch

Which of the following drugs can react with red blood cells (RBCs) to cause hemolysis?

Which of the following would be considered the best immunogen?

Isoantigens found on red blood cells (RBCs) may lead to a hemolytic transfusion reaction because:

When a low molecular weight (<3000 Da) pharmaceutical agent binds to albumin, the pharmaceutical agent is acting as a/an:

How would you treat a mother with type A Rh-negative blood who is pregnant with a type O Rh-positive baby?

Which of the following is an example of an endogenous antigen?

Cells and Organs of the Immune System

Innate Immunity

Antigen Presenting Molecules

Antigen Presenting Cells

Surface Interactions Between T Cells and Antigen-Presenting Cells

Intracellular Signaling and T Cell Activation

B Cell Activation and Signaling

Antibodies

Antibody Diversity

Complement

Phagocytosis and Intracellular Killing

Antibodies and in Vivo Therapy

Antibodies and in Vitro Research and Diagnostic Assays

Immediate Allergic Reactions

Autoimmunity

Transplantation

Antigen Presentation for Cell-Mediated Response

Delayed Type Hypersensitivity Reactions

Cytotoxic T Cells

Natural Killer Cells

Factors That Influence the Immune Response

Cytokines and Biological Modifiers

Vaccines in Theory and Practice

Vaccine-Preventable Diseases

Acquired Immune Deficiency Syndrome

Filters