Exam 12: Genes and Cancer

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Individuals have different ____________________ to environmental agents that cause cancer.

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According to the American Cancer Society, 30 pecent of all cancer deaths is due to

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It is estimated that 50 percent of all cancer deaths are related to behavior. Knowing the risks (and keeping in mind that you have a one in three chance of having cancer), do you feel inclined to alter your lifestyle to reduce your cancer risk? If so, what steps would you take? If not, why not?

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Mutations that convert proto-oncogenes to oncogenes are mutations that cause

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The drug Gleevec is most closely associated with which of the following molecules?

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Which of the following statements about retinoblastoma offers support for the idea that multiple mutations are needed in cancer?

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The primary risk factor for cancer is ____________________.

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Specific aneuploidies are associated with various cancers.

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Which one of the following statements about the BRCA1 gene for breast cancer is FALSE?

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The product of the RB tumor-suppressor gene is found in the cytoplasm.

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The genetic model of colon cancer states that development of colo-rectal cancer requires only one key mutation.

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If retinoblastoma requires mutation in two copies of the RB gene, and familial cases inherit one such mutation, doesn't it seem unlikely that a second mutation would occur in a retinal cell at this specific gene? Yet 90 percent of those individuals who inherit one mutant RB gene develop a second mutation and retinoblastoma. Why does this occur with such a high frequency?

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Which of the following is not a checkpoint in the cell cycle?

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What is the role of oncogenes and tumor-suppressor genes, and how can mutations in these genes lead to cancer?

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Hereditary nonpolyposis colon cancers (HNPCC)

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Burkitt's lymphoma, chronic myelogenous leukemia, and many other leukemias are caused by chromosome ____________________.

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