Question 1

What is the direct product of the base-promoted hydrolysis of an ester?

Accepted Answer

A) A nitrile 
B) A carboxylic acid 
C) An amide 
D) A carboxylic acid salt
Gradable: automatic 
A) A nitrile 
B) A carboxylic acid 
C) An amide 
D) A carboxylic acid salt
Gradable: automatic

Question 2

What reagent would you use for the following transformation?

Accepted Answer

A) LiAlH4 
B) DIBAL-H 
C) NaBH4 
D) H2, Pd/C 
A) LiAlH4 
B) DIBAL-H 
C) NaBH4 
D) H2, Pd/C

Question 3

Will the following reaction occur?

Accepted Answer

A) Yes 
B) No 
A) Yes 
B) No

Question 4

Where do the carbonyl signals appear in the 13C NMR spectrum of carboxylic acid derivatives?

Accepted Answer

A) 1700 cm-1 
B) 180-160 ppm 
C) 2.5-3.0 ppm 
D) 100-80 ppm 
A) 1700 cm-1 
B) 180-160 ppm 
C) 2.5-3.0 ppm 
D) 100-80 ppm

Question 5

Why doesn't nucleophilic acyl substitution stop at the tetrahedral intermediate?

Accepted Answer

A) The nucleophile is too basic. 
B) Reforming the carbonyl is energetically favorable. 
C) The leaving group is unstable and wants to be negatively charged. 
D) There is no tetrahedral intermediate. 
A) The nucleophile is too basic. 
B) Reforming the carbonyl is energetically favorable. 
C) The leaving group is unstable and wants to be negatively charged. 
D) There is no tetrahedral intermediate.

Question 6

How can you convert a carboxylic acid into an acid chloride?

Accepted Answer

A) Heat with hydrochloric acid. 
B) React with thionyl chloride (SOCl2). 
C) React with sodium chloride. 
D) React with Cl2 and FeCl3. 
A) Heat with hydrochloric acid. 
B) React with thionyl chloride (SOCl2). 
C) React with sodium chloride. 
D) React with Cl2 and FeCl3.

What is the direct product of the base-promoted hydrolysis of an ester?

What reagent would you use for the following transformation?

Will the following reaction occur?

Where do the carbonyl signals appear in the ¹³C NMR spectrum of carboxylic acid derivatives?

Why doesn't nucleophilic acyl substitution stop at the tetrahedral intermediate?

How can you convert a carboxylic acid into an acid chloride?

Structure and Bonding

Acids and Bases

Introduction to Organic Molecules and Functional Groups

Alkanes

Stereochemistry

Understanding Organic Reactions

Alkyl Halides and Nucleophilic Substitution

Alkyl Halides and Elimination Reactions

Alcohols, Ethers, and Related Compounds

Alkenes

Alkynes

Oxidation and Reduction

Mass Spectrometry and Infrared Spectroscopy

Nuclear Magnetic Resonance Spectroscopy

Radical Reactions

Conjugation, Resonance, and Dienes

Benzene and Aromatic Compounds

Reactions of Aromatic Compounds

Carboxylic Acids and the Acidity of the O-H Bond

Introduction to Carbonyl Chemistry;

Aldehydes and Ketones Nucleophilic Addition

Substitution Reactions of Carbonyl Compounds at the Alpha-Carbon

Carbonyl Condensation Reactions

Amines

Carbon-Carbon Bond Forming Reactions in Organic Synthesis

Pericyclic Reactions

Carbohydrates

Amino Acids and Proteins

Synthetic Polymers

Lipids

Filters

Exam 22: Carboxylic Acids and Derivatives

What is the direct product of the base-promoted hydrolysis of an ester?

What reagent would you use for the following transformation?

Will the following reaction occur?

Where do the carbonyl signals appear in the 13C NMR spectrum of carboxylic acid derivatives?

Why doesn't nucleophilic acyl substitution stop at the tetrahedral intermediate?

How can you convert a carboxylic acid into an acid chloride?

Structure and Bonding

Acids and Bases

Introduction to Organic Molecules and Functional Groups

Alkanes

Stereochemistry

Understanding Organic Reactions

Alkyl Halides and Nucleophilic Substitution

Alkyl Halides and Elimination Reactions

Alcohols, Ethers, and Related Compounds

Alkenes

Alkynes

Oxidation and Reduction

Mass Spectrometry and Infrared Spectroscopy

Nuclear Magnetic Resonance Spectroscopy

Radical Reactions

Conjugation, Resonance, and Dienes

Benzene and Aromatic Compounds

Reactions of Aromatic Compounds

Carboxylic Acids and the Acidity of the O-H Bond

Introduction to Carbonyl Chemistry;

Aldehydes and Ketones Nucleophilic Addition

Substitution Reactions of Carbonyl Compounds at the Alpha-Carbon

Carbonyl Condensation Reactions

Amines

Carbon-Carbon Bond Forming Reactions in Organic Synthesis

Pericyclic Reactions

Carbohydrates

Amino Acids and Proteins

Synthetic Polymers

Lipids

Filters

Where do the carbonyl signals appear in the ¹³C NMR spectrum of carboxylic acid derivatives?