Exam 14: Gene Mutation, Dna Repair, and Transposition

Although mutation is the original source of genetic variation, its influence on changing allelic frequencies is relatively minor.

Conditional mutations are more likely to result from a mutation caused by which of the following alterations to the coding region of a gene?

All insertion sequences (IS elements) contain two features that are essential for their movement. What are these two elements?

Barbara McClintock discovered mobile elements in corn by analyzing the genetic behavior of two elements, Ds and A c. The interplay between these two elements has become one of the most interesting stories of discovery in the field of genetics. How do Ds and Ac interact?

Ultraviolet light causes pyrimidine dimers to form in DNA. Some individuals are genetically incapable of repairing some dimers at "normal" rates. Such individuals are likely to suffer from ________.

Which human condition is caused by unrepaired UV -induced lesions?

What is the common influence of ultraviolet light on DNA?

The shorter the wavelength of a radiation source, the greater its likelihood of causing damage.

Mutations may exert a variety of effects on living systems. List at least three categories of mutations based on their biological effects.

A missense mutation causes premature chain (protein) termination.

Postreplication repair is a system that responds after damaged DNA has escaped repair and failed to be completely replicated.

Recombinational repair is activated when damaged DNA has escaped repair and the distortion disrupts the process of replication. Which gene is responsible for recombinational repair?

In a survey of 240,000 human births, 6 achondroplastic births were recorded to parents who were unaffected. Given that this form of dwarfism is caused by a fully penetrant, dominant, autosomal gene, what is the mutation rate?