Question 1

The ends of chromosomes are called ________.

Accepted Answer

A) telomeres 
B) centromeres 
C) caps 
D) DNA termini 
A) telomeres 
B) centromeres 
C) caps 
D) DNA termini A

Question 2

Humans are diploid organisms,containing two sets of chromosomes.How many sets of chromosomes does wheat,Triticum aestivum,have?

Accepted Answer

A) 1 
B) 2 
C) 4 
D) 6 
E) 8 
A) 1 
B) 2 
C) 4 
D) 6 
E) 8 D

Question 3

A pharmaceutical company is developing a new drug to treat a rare disease.They need to determine which of the cell's proteins can bind the drug.What tool can help them survey the proteome for drug interactions?

Accepted Answer

A) Protein microarray 
B) DNA microarray 
C) SAGE 
D) ENCODE 
E) Using a monoclonal antibody 
A) Protein microarray 
B) DNA microarray 
C) SAGE 
D) ENCODE 
E) Using a monoclonal antibody A

Question 4

How did the rice genome project influence other genome projects?

Accepted Answer

A) It was the first genome sequenced,so it proved it could be done. 
B) It sped up the genome analysis of other cereal crops,due to synteny. 
C) It sped up the analysis of the human genome,since rice has even more genes. 
D) It helped analysis of all genomes,since it was the basis of the ENCODE algorithms. 
A) It was the first genome sequenced,so it proved it could be done. 
B) It sped up the genome analysis of other cereal crops,due to synteny. 
C) It sped up the analysis of the human genome,since rice has even more genes. 
D) It helped analysis of all genomes,since it was the basis of the ENCODE algorithms.

Question 5

The most ethical decisions for usage of genomic data and technology,like sequencing human genomes for customized treatments and constructing deadly pathogens for study,are based on (Select all that apply)

Accepted Answer

A) consensus in the scientific community. 
B) oversight from governmental agencies. 
C) the directives of large financial donors. 
D) what can safely be achieved in the laboratory. 
E) subjectivity. 
A) consensus in the scientific community. 
B) oversight from governmental agencies. 
C) the directives of large financial donors. 
D) what can safely be achieved in the laboratory. 
E) subjectivity.

Question 6

An accurate and comprehensive description of pseudogenes must include the statement that (Select all that apply)

Accepted Answer

A) pseudogenes may have some gene-like features such as a promoter and splice sites. 
B) pseudogenes encode proteins,but the translated proteins are non-functional. 
C) pseudogenes can provide insight into the evolutionary history of the related functional gene. 
D) every pseudogene has a similar DNA sequence to some functional gene. 
E) all pseudogene pretend to transcribe other genes when they only transcribe one type of genetic information. 
A) pseudogenes may have some gene-like features such as a promoter and splice sites. 
B) pseudogenes encode proteins,but the translated proteins are non-functional. 
C) pseudogenes can provide insight into the evolutionary history of the related functional gene. 
D) every pseudogene has a similar DNA sequence to some functional gene. 
E) all pseudogene pretend to transcribe other genes when they only transcribe one type of genetic information.

Question 7

As the director of a new nonprofit functional genomics research center,it is your job to oversee the set up of each laboratory necessary for achieving the center's research goals.Therefore,you plan to include a(n)(Select all that apply)

Accepted Answer

A) DNA microarray facility. 
B) proteomics lab. 
C) lab to improve sequencing speed and cost. 
D) mutagenesis facility. 
E) ancient DNA laboratory. 
A) DNA microarray facility. 
B) proteomics lab. 
C) lab to improve sequencing speed and cost. 
D) mutagenesis facility. 
E) ancient DNA laboratory.

Question 8

Long interspersed elements (LINEs)are a type of

Accepted Answer

A) pseudogene. 
B) proteome. 
C) exon. 
D) intron. 
E) transposon. 
A) pseudogene. 
B) proteome. 
C) exon. 
D) intron. 
E) transposon.

Question 9

A human gene is composed of numerous fragments of protein-encoding information known as ________.

Accepted Answer

A) DNA 
B) mRNA 
C) exons 
D) introns 
A) DNA 
B) mRNA 
C) exons 
D) introns

Question 10

As a scientist working for an anti-bioterrorism task force,you are asked to evaluate some biological samples for the presence of Yersinia pestis,the organism that causes the plague.After confirming that the samples do contain Y.pestis,you instruct your team to begin sequencing the strain.Since the genome sequence of Y.pestis is already known,why would sequencing this strain be useful?

Accepted Answer

A) To provide better data for the genome database 
B) To establish the course of infection,and determine whether the strain is altered by causing infection 
C) To help determine the source of the strain,and learn whether it has been genetically engineered 
D) To create a vaccine for this particular strain 
A) To provide better data for the genome database 
B) To establish the course of infection,and determine whether the strain is altered by causing infection 
C) To help determine the source of the strain,and learn whether it has been genetically engineered 
D) To create a vaccine for this particular strain

Question 11

Identical copies of genes that can be transcribed simultaneously are called

Accepted Answer

A) segmental duplications. 
B) pseudogenes. 
C) tandem clusters. 
D) multigene families. 
E) expressed sequences. 
A) segmental duplications. 
B) pseudogenes. 
C) tandem clusters. 
D) multigene families. 
E) expressed sequences.

Question 12

In vertebrates,the family of myogenic regulatory factors (MRFs)plays a major role in muscle development.This family consists of four related genes which have distinct but overlapping functions.This gene family is represented by only a single gene in Drosophila,called nautilus.You want to know whether nautilus plays a role like all of the MRFs put together,or more like one in particular.What is a quick and easy way to begin to address this question?

Accepted Answer

A) Compare the DNA and protein sequences of all the genes to determine if nautilus is more similar to one MRF than another. 
B) Use a DNA microarray to compare gene activation patterns between nautilus and the MRFs. 
C) Compare the proteome of a cell expressing nautilus to the those of cells expressing each of the MRFs in turn. 
D) Generate four transgenic Drosophila strains that express the MRFs in a mutant nautilus background. 
A) Compare the DNA and protein sequences of all the genes to determine if nautilus is more similar to one MRF than another. 
B) Use a DNA microarray to compare gene activation patterns between nautilus and the MRFs. 
C) Compare the proteome of a cell expressing nautilus to the those of cells expressing each of the MRFs in turn. 
D) Generate four transgenic Drosophila strains that express the MRFs in a mutant nautilus background.

Question 13

Mobile bits of DNA that can jump from one location on a chromosome to another location are called

Accepted Answer

A) simple sequence repeats. 
B) transposons. 
C) exons. 
D) introns. 
E) pseudogenes. 
A) simple sequence repeats. 
B) transposons. 
C) exons. 
D) introns. 
E) pseudogenes.

Question 14

Recombination frequency between genes can be used to generate a

Accepted Answer

A) genetic map. 
B) physical map. 
C) restriction map. 
D) haplotype map. 
A) genetic map. 
B) physical map. 
C) restriction map. 
D) haplotype map.

Question 15

Using actual landmarks within DNA sequences,scientists can generate a ________ map.

Accepted Answer

A) genetic 
B) DNA 
C) physical 
D) chromosomal 
A) genetic 
B) DNA 
C) physical 
D) chromosomal

Question 16

Both dideoxy terminator and next-generation sequencing methods require a genomic library to be constructed prior to sequencing the DNA of interest.

Accepted Answer

A) True 
 B)False

Question 17

The organism with the largest relative genome size is

Accepted Answer

A) rice. 
B) human. 
C) fruit fly. 
D) yeast. 
A) rice. 
B) human. 
C) fruit fly. 
D) yeast.

Question 18

The sequencing method that cuts DNA segments into fragments,arranges those fragments based on overlapping nucleotide sequences,and then clones these fragments is called

Accepted Answer

A) shotgun sequencing. 
B) clone-by-clone sequencing. 
C) RFLP sequencing. 
D) consensus sequencing. 
A) shotgun sequencing. 
B) clone-by-clone sequencing. 
C) RFLP sequencing. 
D) consensus sequencing.

Question 19

The important advances stemming from comparative genomics include the ability to (Select all that apply)

Accepted Answer

A) draw particular conclusions about species. 
B) draw general conclusions about evolution. 
C) infer function about an unsequenced genome using synteny. 
D) develop a haplotype map. 
E) distinguish how proteins bind to receptors. 
A) draw particular conclusions about species. 
B) draw general conclusions about evolution. 
C) infer function about an unsequenced genome using synteny. 
D) develop a haplotype map. 
E) distinguish how proteins bind to receptors.

Question 20

Which of the following were challenges that had to be overcome to sequence the genome of wheat,Triticum aestivum? (Select all that apply)

Accepted Answer

A) Lack of advanced sequencing technology 
B) Large genome size (~5 times as large as human genome) 
C) High mutation rate of wheat genes 
D) Lack of interest/support in sequencing the genome 
E) An abundance of repetitive DNA 
A) Lack of advanced sequencing technology 
B) Large genome size (~5 times as large as human genome) 
C) High mutation rate of wheat genes 
D) Lack of interest/support in sequencing the genome 
E) An abundance of repetitive DNA

Exam 18: Genomics

The ends of chromosomes are called ________.

Humans are diploid organisms,containing two sets of chromosomes.How many sets of chromosomes does wheat,Triticum aestivum,have?

A pharmaceutical company is developing a new drug to treat a rare disease.They need to determine which of the cell's proteins can bind the drug.What tool can help them survey the proteome for drug interactions?

How did the rice genome project influence other genome projects?

The most ethical decisions for usage of genomic data and technology,like sequencing human genomes for customized treatments and constructing deadly pathogens for study,are based on (Select all that apply)

An accurate and comprehensive description of pseudogenes must include the statement that (Select all that apply)

As the director of a new nonprofit functional genomics research center,it is your job to oversee the set up of each laboratory necessary for achieving the center's research goals.Therefore,you plan to include a(n)(Select all that apply)

Long interspersed elements (LINEs)are a type of

A human gene is composed of numerous fragments of protein-encoding information known as ________.

Identical copies of genes that can be transcribed simultaneously are called

Mobile bits of DNA that can jump from one location on a chromosome to another location are called

Recombination frequency between genes can be used to generate a

Using actual landmarks within DNA sequences,scientists can generate a ________ map.

Both dideoxy terminator and next-generation sequencing methods require a genomic library to be constructed prior to sequencing the DNA of interest.

The organism with the largest relative genome size is

The sequencing method that cuts DNA segments into fragments,arranges those fragments based on overlapping nucleotide sequences,and then clones these fragments is called

The important advances stemming from comparative genomics include the ability to (Select all that apply)

Which of the following were challenges that had to be overcome to sequence the genome of wheat,Triticum aestivum? (Select all that apply)

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